Depressive and Anxious Symptoms in Hepatitis C Virus Infected Patients Receiving DAA-Based Therapy

Danilescu, Claudia Monica; Săndulescu, Larisa; Pîrlog, Mihail Cristian; Streba, Costin Teodor; Rogoveanu, Ion

doi:10.3390/diagnostics11122237

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…Finally, the third assessment point was at the follow-up (Sustain Viral Response-12 weeks after the end of the treatment-SVR) when same package of clinical and laboratory data was assessed [3].…”

Section: Methodsmentioning

confidence: 99%

Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

et al. 2022

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The Hepatitis C Virus (HCV) infection often associates medical and mental health conditions which lead to increased levels of distress. Our study aimed at assessing the level of perceived stress on a sample of 90 HCV infected patients treated with Direct-Acting Antiviral (DAA) agents for 12 weeks, and its possible correlations with clinical and evolutionary elements. The evaluation was conducted in three phases: before administration of the DAAs (BSL), at the End of the Treatment (EOT), and 24 weeks after the BSL (Sustained Viral Response—SVR). The perceived stress was measured using the Perceived Stress Scale (PSS). The efficiency of the DAA treatment reduced the levels of stress (98.99% moderate and high stress at BSL to 70.00% at SVR). It was observed, for the entire study period (BSL to SVR), that the decrease in the perceived stress severity was significantly associated with demographic items such as gender (p < 0.01), urban environment (p < 0.001), the age of the subjects (p < 0.05), and clinical data such as F4 degree of fibrosis (p = 0.001) and overweight or obesity class II (p < 0.01). The perceived stress is directly associated with the severity of the HCV infection, and it could be significantly lowered by an efficient therapeutic approach, as DAAs are nowadays.

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Section: Methodsmentioning

confidence: 99%

Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

et al. 2022

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“…Hepatitis C virus infection results in symptoms associated with mental health conditions, decreased quality of life and nancial losses, disturbed social situations, and increased health care needs, all of which led to increased stress (Danilescu et al 2021). Hepatitis C virus infection is a serious medical condition that causes emotional distress as a result of multiple problems, including physical symptoms resulting from the disease and associated treatment.…”

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psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment

Haggag¹

2022

Preprint

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Background This research aimed to identify psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment. An Internet-based cross-sectional study was conducted where the available sample was selected from 379 HCV patients and another uninfected sample consisting of 381 respondents, bringing the total to approximately 760 respondents between January 4 and October 28, 2021. Participants completed four self-reported scales. The scales included the psychosocial stressors of patients scale (PSPS), Beck depression inventory (BDI-I), the state-trait anxiety inventory (STAI) and general adjustment scale (GAS). Results The results reveal that there are differences between patients with HCV-positive, patients with HCV-negative and healthy people in the psychosocial stressors in favor of patients with HCV-positive. There was a positive correlation between psycho-social stressors of hepatitis C patients with anxiety, depression, adjustment and age. There were differences between patients with HCV and healthy people in the following variables: anxiety, depression, healthy adjustment, family adjustment, professional adjustment, social adjustment and general adjustment in favor of patients with HCV. There were differences between patients with HCV-positive and patients with HCV-negative in the following variables: anxiety, depression, healthy adjustment, family adjustment, social adjustment and general adjustment in favor of patients with HCV-positive. Conclusions This study recommended that care must be taken in the counseling and psychotherapy of HCV patients to reduce the mental disorders associated with the disease.

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Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine

Park,

Shin,

Jeon

et al. 2024

Biomol Ther (Seoul)

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Viral infections are increasingly recognized as triggers for depressive disorders, particularly following the SARS-CoV-2 pandemic and the rise of long COVID. Viruses such as Herpes Simplex Virus (HSV), Epstein-Barr Virus (EBV), Cytomegalovirus (CMV), and Human Immunodeficiency Virus (HIV) are linked to depression through complex neurobiological mechanisms. These include immune system dysregulation, chronic inflammation, and neurotransmitter imbalances that affect brain function and mood regulation. Viral activation of the immune system leads to the release of pro-inflammatory cytokines, resulting in neuroinflammation and associated depressive symptoms. Furthermore, specific viruses can disrupt neurotransmitter systems, including serotonin, dopamine, and glutamate, all of which are essential for mood stabilization. The unique interactions of different viruses with these systems underscore the need for virus-specific therapeutic approaches. Current broad-spectrum treatments often overlook the precise neurobiological pathways involved in post-viral depression, reducing their efficacy. This review emphasizes the need to understand these virus-specific interactions to create tailored interventions that directly address the neurobiological effects induced by each type of virus. These interventions may include immunomodulatory treatments that target persistent inflammation, antiviral therapies to reduce the viral load, or neuroprotective strategies that restore neurotransmitter balance. Precision medicine offers promising avenues for the effective management of virus-induced depression, providing patient-specific approaches that address the specific biological mechanisms involved. By focusing on the development of these targeted treatments, this review aims to pave the way for a new era in psychiatric care that fully addresses the root causes of depression induced by viral infections.

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Depressive and Anxious Symptoms in Hepatitis C Virus Infected Patients Receiving DAA-Based Therapy

Cited by 3 publications

References 42 publications

Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

Perceived Stress in Hepatitis C Virus Infected Patients under the DAA-Based Therapy

psycho-social stressors among hepatitis C virus patients and its relationship to anxiety, depression and adjustment

Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine

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