Depressive episodes in patients with multiple sclerosis

Rb, Schiffer; Ed, Caine; Ka, Bamford; Levy, Shellie-Anne

doi:10.1176/ajp.140.11.1498

Cited by 122 publications

(4 citation statements)

References 7 publications

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“…In our study, the presence of left MCP lesions was associated with an almost nine-point reduction in depression, anxiety, and stress scores meaning that the lesions had a protective effect against depressive symptoms. In agreement with our finding, Schiffer et al, 33 in an old research conducted on 30 patients with MS, reported that patients with cerebellar involvement were less likely to be depressed than patients with cerebral involvement. As recent evidence exists for the emotional lateralization in the brain, 34 our finding is logical in context of the theory that the right cerebral hemisphere is specialized for perception, expression, and experience of emotion.…”

Section: Discussionsupporting

confidence: 93%

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Hamdy

Ramadan

Mekky

et al. 2022

Int Clin Neurosci J

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Background: Cerebellum has long been known to modulate not only motor coordination but also affective and cognitive functions. This study aimed to assess the impact of middle cerebellar peduncle (MCP) lesions on affective and cognitive function in patients with multiple sclerosis (MS). Methods: This was a cross-sectional study conducted on patients with relapsing-remitting MS (RRMS). All patients were subjected to 3-Tesla magnetic resonance imaging (3T MRI), brief international cognitive assessment for MS (BICAMS), and Depression, Anxiety, and Stress Score-21 (DASS-21) upon recruitment. Results: Of the 30 patients recruited, 33.3% and 36.7% had right and left MCP lesions, respectively. Patients with right MCP lesions had significantly worse symbol digit modality test (SDMT) scores (P=0.036), worse California verbal learning test (CVLT) immediate recall scores (P=0.011), and worse CVLT delayed free recall scores (P=0.049), whereas patients with left MCP lesions had lower DASS-21 scores (P<0.005). On multivariate regression analysis, the presence of left MCP lesion was associated with an 8.9-point reduction in DASS-21 scores (CI: -16.985- -0.805, P=0.033), whereas right MCP lesions did not have an independent effect on BICAMS scores after adjustment for age and educational level. Conclusion: Left MCP lesions were associated with significantly lower DASS-21 scores, whereas none of the MCP lesions had an independent impact on cognition.

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Section: Discussionsupporting

confidence: 93%

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Hamdy

Ramadan

Mekky

et al. 2022

Int Clin Neurosci J

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“…Depression was a negative consequence of increased disability, and it directly contributed to fatigue and catastrophizing about fatigue. Depression is known to be the most common psychiatric disorder in MS, with an estimated prevalence ranging between 27 and 54% (Minden et al 1987; Minden and Schiffer 1990; Sadovnick et al 1996; Schiffer et al 1983). Therefore, we recommend the inclusion of depression in screening procedures and treatment for fatigued MS patients.…”

Section: Discussionmentioning

confidence: 99%

Fatigue and physical disability in patients with multiple sclerosis: a structural equation modeling approach

et al. 2010

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Although fatigue is one of the most common and disabling symptoms in patients with multiple sclerosis (MS), its pathogenesis is still poorly understood and it is difficult to treat. The aim of the current study was to test the assumptions of a cognitive-behavioral model that explains fatigue and physical disability in MS patients, by comparing this approach with a more traditional biomedical approach. Structural equation modeling was applied to a sample of 262 MS patients. Neither the cognitive-behavioral, nor the biomedical model showed an adequate fit of our data. The modification indices supported an integration of both models, which showed a better fit than those of the separate models. This final model, is notable for at least three features: (1) fatigue is associated with depression and physical disability, (2) physical disability is associated with disease severity and fatigue-related fear and avoidance behavior, and (3) catastrophic interpretations about fatigue, fueled by depression, mediated the relationship between fatigue and fatigue-related fear and avoidance behavior. Our results suggest that an integrated approach, including the modification of catastrophic thoughts about fatigue, would be beneficial in the treatment of fatigue in MS patients.

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“…Patten [ 21 ] reported a prevalence of depressive symptoms of 25.7% of 163 subjects and Bamer [ 22 ] examined 530 people with MS from Eastern Washington and 138 subjects from Western Washington, with a prevalence of depressive symptoms respectively, of 51% and 45%. A lifetime prevalence of depressive symptoms of 22.8%, in a sample of 30 people with MS, was reported by Schiffer [ 23 ] using a psychiatric interview and the BDI. Joffe [ 24 ] and Minden [ 25 ] reported respectively, a lifetime prevalence of 42% in 100 people with MS and of 54% in 50 people with MS using the RDC.…”

Section: Introductionmentioning

confidence: 94%

Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory

Solaro¹,

Trabucco

Signori

et al. 2016

PLoS ONE

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BackgroundDepression occurs in about 50% of patients with multiple sclerosis. The aims of this study was to investigate the prevalence of depressive symptoms in a multicenter MS population using the Beck Depression Inventory II (BDI II) and to identify possible correlations between the BDI II score and demographic and clinical variables.MethodsData were collected in a multi-center, cross-sectional study over a period of six months in six MS centers in Italy using BDI II.Results1,011 MS patients participated in the study. 676 subjects were female, with a mean age of 34 years (SD 10.8), mean EDSS of 3.3 (0–8.5) and mean disease duration of 10.3 years (range 1–50 years). 668 (%) subjects scored lower than 14 on the BDI II and 343 (33.9%) scored greater than 14 (14 cut-off score). For patients with BDI>14 multivariate analysis showed a significant difference between EDSS and disease course. BDI II scores for subjects with secondary progressive (SP) MS were significantly different from primary progressive (PP) patients (p < 0.001) but similar to relapsing-remitting (RR) patients. Considering subjects with moderate to severe depressive symptoms (BDI II score from 20–63), in relation to disease course, 11.7% (83/710) had RR MS, 40.7% (96/236) SP and 13.6% (6/44) PP.ConclusionsUsing the BDI II, 30% of the current sample had depressive symptoms. BDI II score correlates with disability and disease course, particularly in subjects with SP MS. The BDI II scale can be a useful tool in clinical practice to screen depressive symptoms in people with MS.

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Depressive episodes in patients with multiple sclerosis

Cited by 122 publications

References 7 publications

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Middle Cerebellar Peduncle Lesions and Their Relation to Affective and Cognitive Impairment in Multiple Sclerosis

Fatigue and physical disability in patients with multiple sclerosis: a structural equation modeling approach

Depressive Symptoms Correlate with Disability and Disease Course in Multiple Sclerosis Patients: An Italian Multi-Center Study Using the Beck Depression Inventory

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