Depressive Symptoms and CD4 Lymphocyte Decline Among HIV-Infected Men

Burack, Jeffrey H.; Barrett, Donald C.; Stall, Ron; Chesney, Margaret A.; Coates, Thomas J.

doi:10.1001/jama.1993.03510210054027

Cited by 308 publications

(177 citation statements)

References 25 publications

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“…Additionally, we found the CES-D to be a valid and reliable measure of depressive symptoms in rural Uganda. Some earlier studies from developed countries showed no association between depression and disease progression (Burack et al, 1993;Lyketsos, Hoover, & Guccione, 1996a;Lyketsos et al, 1996c), although more recent studies have documented as association (Ickovics et al, 2001;Leserman et al, 1999;Page-Shafer et al, 1996). We found a clear association between disease severity, as measured by CD4 count, and depressive symptoms.…”

Section: Discussionsupporting

confidence: 43%

Depression and CD4 Cell Count Among Persons with HIV Infection in Uganda

et al. 2006

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Despite the importance of mental illness and the high prevalence of HIV in Africa, few studies have documented depressive symptoms among HIV-infected persons in Africa. We assessed factors associated with depression among HIV-infected adults undergoing anti-retroviral eligibility screening in Eastern Uganda. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale (CES-D). Univariate and multiple regression analyses were conducted to identify socio-demographic characteristics and disease-related factors associated with depression. Among 1017 HIV-infected participants assessed for depression, 47% (476/1017) reported depressive symptoms (CES-D >/= 23). Adjusting for age, gender, education, and source of income, patients with CD4 counts <50 cells/microl were more likely to be depressed (odds ratio 2.34, 95% confidence interval, 1.39-3.93, P = 0.001). Women, participants >50 years, and those without an income source were more likely to be depressed. Depression was common among HIV-infected persons in rural Uganda and was associated with low CD4 cell counts. Appropriate screening and treatment for depression should be considered for comprehensive HIV care.

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Section: Discussionsupporting

confidence: 43%

Depression and CD4 Cell Count Among Persons with HIV Infection in Uganda

et al. 2006

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“…The earlier study, however, showed an association between baseline depression and decline in CD4 T-lymphocytes [20]. In another analysis of the same cohort during 7 years of follow-up, researchers found that those who had elevated symptoms of depression at every visit, had a 1.7 times greater risk of mortality compared to those who never had an elevated depression score [21].…”

Section: Depression and Hiv Disease Progressionmentioning

confidence: 92%

The effects of depression, stressful life events, social support, and coping on the progression of HIV infection

Leserman

2000

Curr Psychiatry Rep

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This article reviews recent findings concerning the role of psychosocial factors on the progression of HIV. Specifically, we examine the role of depression, stressful life events, social support, and coping on changes in CD4 T-lymphocytes and other indicators of HIV disease progression. Studies have yielded important evidence that depression, stressful life events, low social support, and denial coping may have a detrimental impact on HIV disease course. Delineating the role of psychosocial factors on HIV disease progression may aid in the development of new interventions for this devastating disease.

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“…Results from longitudinal cohort studies of depression are less consistent. Although some investigators failed to fi nd such an association [29][30][31][32], others did fi nd one (eg, [33]). …”

Section: Depression Hiv Stage and Mortalitymentioning

confidence: 99%

HIV and depression: 2008 review and update

2008

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Since the earliest days of the AIDS epidemic, clinicians have been concerned about the prevalence of depression among their patients. Epidemiologists, psychiatrists, psychologists, sociologists, and a broad array of other specialists have studied this topic, trying to determine the prevalence of depressive disorders and depressive symptoms as well as antecedents, correlates, and consequences. This review addresses the methodologic difficulties in determining depression prevalence, major findings regarding rates of disorder and correlates among different segments of the HIV community, effects of depression on HIV illness progression, psychopharmacologic and psychotherapeutic treatment findings, and behavioral effects of depression, such as its impact on medication adherence, employment, and risk behavior. Finally, the article summarizes international studies of depression prevalence in developing countries and the challenges regarding cross-national diagnostic definitions and measures.

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Depressive Symptoms and CD4 Lymphocyte Decline Among HIV-Infected Men

Cited by 308 publications

References 25 publications

Depression and CD4 Cell Count Among Persons with HIV Infection in Uganda

Depression and CD4 Cell Count Among Persons with HIV Infection in Uganda

The effects of depression, stressful life events, social support, and coping on the progression of HIV infection

HIV and depression: 2008 review and update

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