Depressive Symptoms and Quality of Life in Age-related Macular Degeneration Based on Korea National Health and Nutrition Examination Survey (KNHANES)

Ryu, So Jung; Lee, Won June; Tarver, Leslie; Shin, Yong Un; Kang, Min Ho; Seong, Mincheol; Cho, Hee Yoon

doi:10.3341/kjo.2016.0086

Cited by 9 publications

(12 citation statements)

References 29 publications

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“…Prior studies showed a great inconsistency in the prevalence of depression in patients with AMD. Depression prevalence varied between 2% and 44.4% in different studies 8,10,11,[31][32][33][34][35] . Anxiety prevalence among AMD patients was reported to be as high as 10.5% in Australia 32 and 11.7% 31 and 30.1% 8 in Germany.…”

Section: Discussionmentioning

confidence: 99%

“…Findings from population-based studies were contradictory. In a Korean population-based study, participants with AMD more often reported depressive symptoms and in an Australian population-based study AMD was associated with depression, but not with anxiety 32,35 . Prevalence of early and late AMD was not considered in those studies.…”

Section: No Depression (1011) Depression (78) P-valuementioning

confidence: 94%

“…A detailed description of the study design has been published elsewhere 12 . Study sample. Cross-sectional data analyses were based on 11,834 participants (out of 15,010 participants) aged 35 to 74 years at the baseline of the Gutenberg Health Study (GHS), for whom ophthalmological findings, depression and anxiety scores were available. Longitudinal analyses were based on data from 8,098 and 9,039 participants with available depression and anxiety measurements, respectively, with 5-year follow-up examinations carried out between April 2012 and April 2017 with an overall participation rate of 82.8% (see Beutel et al 2018 for details) 13 .…”

Section: Methodsmentioning

confidence: 99%

“…In this study, a single question ("Have you felt sorrow or despair that has affected your daily life for more than 2 weeks continuously during the past year?") was provided to measure the degree of depressive symptoms, which may limit the accuracy of the responses 35 . In contrast, the PHQ-9 we applied is an established survey instrument in Germany with an high reliability and validity and is reportedly a useful screening tool for identifying symptoms of depression 19,[38][39][40] .…”

Section: No Depression (1011) Depression (78) P-valuementioning

confidence: 99%

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Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Rezapour

Schuster

Nickels

et al. 2020

Sci Rep

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to investigate the prevalence and new onset of depression and anxiety among subjects with agerelated macular degeneration (AMD) and its association with AMD in a large european cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70-1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47-0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD-and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.Age-related macular degeneration (AMD) is a chronic, progressive eye disease that leads to central visual loss due to death of photoreceptors caused by loss of retinal pigment epithelium. Advanced stages may result in geographic atrophy and/or choroidal neovascularization in the central retina. Accounting for approximately 6% of blindness worldwide, AMD is the fourth most common cause of blindness 1 .Age is one of the main risk factors for developing AMD 1 and longer life expectancy in aging populations result in an increasing number of individuals with AMD 1,2 ; an estimated 196 million individuals were affected in 2020 rising to a predicted 288 million in 2040 3 . In 2014, early and late AMD was detected in 11.9% and 0.2%, www.nature.com/scientificreports www.nature.com/scientificreports/ respectively, of individuals aged 35-74 years in Germany 4 . Treatment of "wet AMD" incorporates anti-VEGF injections that may slow down disease progression and stabilise vision 1,5 .Recently, ophthalmologists have been advised to identify and consider mental distress in those with vision loss 6 because advanced vision loss has a major impact on a person's quality of life. An inability to continue work and hobbies, and decreased mobility may adversely affect social integration and can be associated with depression. While depression is one of the leading contributors to the global disease burden, it is often accompanied by anxiety 7 . Accordingly, the prevalence of depression and anxiety in AMD patients has been subject of several studies, however reported results have been inconsistent.A European study found that poor visual acuity, but not the presence of AMD was positively associated w...

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Section: Discussionmentioning

confidence: 99%

Section: No Depression (1011) Depression (78) P-valuementioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: No Depression (1011) Depression (78) P-valuementioning

confidence: 99%

See 2 more Smart Citations

Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Rezapour

Schuster

Nickels

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…None of these problems have been previously studied in any other country in relation to place of residence, it is therefore impossible to generalize that this is a global problem. In Poland, such discrepancies are also easily visible also in patients suffering from other diseases [12].…”

Section: Discussionmentioning

confidence: 96%

Quality of life among patients from urban and rural areas with advanced age-related macular degeneration assessed using the NEI-VFQ-25

Święch-Zubilewicz

Dolar-Szczasny

Wróbel-Dudzińska

et al. 2021

Ann Agric Environ Med.

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Impact of major age-related eye disorders on health-related quality of life assessed by EQ-5D: a systematic review and meta-analysis

Kai

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Depressive Symptoms and Quality of Life in Age-related Macular Degeneration Based on Korea National Health and Nutrition Examination Survey (KNHANES)

Cited by 9 publications

References 29 publications

Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Quality of life among patients from urban and rural areas with advanced age-related macular degeneration assessed using the NEI-VFQ-25

Impact of major age-related eye disorders on health-related quality of life assessed by EQ-5D: a systematic review and meta-analysis

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