Depressive Symptoms at Discharge from Rehabilitation Predict Future Cardiovascular-Related Hospitalizations

Meyer, Fiorenza Angela; Hugentobler, Eva; Stauber, Stefanie; Wilhelm, Matthias; Znoj, Hansjörg; Känel, Roland von

doi:10.1159/000375231

Cited by 8 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inpatients with CVD presenting positive screening for depression at discharge have a 2.5 fold increase in relative risk of experiencing a CVD-related hospitalization, even after adjustment for traditional cardiovascular risk factors and measures of disease severity[13]. …”

Section: Introductionmentioning

confidence: 99%

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Barreto

Garcia

Prado

et al. 2017

WJP

View full text Add to dashboard Cite

AIMTo identify factors associated with depressive symptoms among inpatients with cardiovascular disease (CVD).METHODSThis is a cross-sectional study performed in a subsample of a large cross-sectional research that investigated affective disorders and suicide behaviour among inpatients hospitalized in non-surgical wards of the University Hospital of the Federal University of Minas Gerais from November 2013 to October 2015. Sociodemographic and clinical data were obtained through a structured interview and medical record review. Depression was assessed by the depression subscale of the Hospital Anxiety and Depression Scale, with scores ≥ 8 considered as positive screening for depression. We used the Fageström Test for Nicotine Dependence to characterize nicotine dependence. For assessing resilience and early-life trauma, we used the raw scores of the Wagnild and Young Resilience Scale and Childhood Trauma Questionnaire, respectively.RESULTSAt endpoint, we included 137 subjects. Thirty-eight (27.7%) subjects presented depressive symptoms and nine (23.7%) of those were receiving antidepressant treatment during hospitalization. The female sex; a lower mean educational level; a greater prevalence of previous suicide attempts; a higher level of pain; a higher prevalence of family antecedents of mental disorders; a lower resilience score; and higher childhood trauma score were the factors significantly associated with screening positive for major depression (P < 0.05). Multivariate analysis demonstrated that the factors independently associated with the depressive symptoms were a higher childhood trauma severity (OR = 1.06; P = 0.004); moderate to severe nicotine dependence (OR = 8.58; P = 0.008); and the number of previous hospital admissions (OR = 1.11; P = 0.034). The obtained logistic model was considered valid, indicating that the three factors together distinguished between having or not depressive symptoms, and correctly classified 74.6% of individuals in the sample.CONCLUSIONOur results demonstrate that inpatients presenting both CVD and a positive screening for depression are more prone to have antecedents of childhood trauma, nicotine dependence and a higher number of previous hospitalizations.

show abstract

Section: Introductionmentioning

confidence: 99%

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Barreto

Garcia

Prado

et al. 2017

WJP

View full text Add to dashboard Cite

show abstract

“…Our findings may help to understand why patients with treatment resistant depression, 33 incident depression 19 and more severe depression 34 show a particularly poor prognosis following MI. As a constant severity of cognitive depressive mood over 1 year was related to D‐dimer, hypercoagulability might prevail in the first year after MI in patients who experience no reduction in cognitive depressive symptoms (with or without treatment).…”

Section: Discussionmentioning

confidence: 83%

Longitudinal association between cognitive depressive symptoms and D‐dimer levels in patients following acute myocardial infarction

Känel

Pazhenkottil

Meister-Langraf

et al. 2021

Clinical Cardiology

Self Cite

View full text Add to dashboard Cite

Background A prothrombotic tendency could partially explain the poor prognosis of patients with coronary heart disease and depression. We hypothesized that cognitive depressive symptoms are positively associated with the coagulation activation marker D‐dimer throughout the first year after myocardial infarction (MI). Methods Patients with acute MI (mean age 60 years, 85% men) were investigated at hospital admission (n = 190), 3 months (n = 154) and 12 months (n = 106). Random linear mixed regression models were used to evaluate the relation between cognitive depressive symptoms, assessed with the Beck depression inventory (BDI), and changes in plasma D‐dimer levels. Demographics, cardiac disease severity, medical comorbidity, depression history, medication, health behaviors, and stress hormones were considered for analyses. Results The prevalence of clinical depressive symptoms (13‐item BDI score ≥ 6) was 13.2% at admission and stable across time. Both continuous (p < .05) and categorical (p < .010) cognitive depressive symptoms were related to higher D‐dimer levels over time, independent of covariates. Indicating clinical relevance, D‐dimer was 73 ng/ml higher in patients with a BDI score ≥ 6 versus those with a score < 6. There was a cognitive depressive symptom‐by‐cortisol interaction (p < .05) with a positive association between cognitive depressive symptoms and D‐dimer when cortisol levels were high (p < .010), but not when cortisol levels were low (p > .05). Fluctuations (up and down) of cognitive depressive symptoms and D‐dimer from one investigation to the next showed also significant associations (p < .05). Conclusions Cognitive depressive symptoms were independently associated with hypercoagulability in patients up to 1 year after MI. Hypothalamic–pituitary–adrenal axis could potentially modify this effect.

show abstract

“…They also found, however, that severity of cardiac disease accounted for this increased risk. In spite of these findings, many studies have suggested that the association between depressive symptoms and poor prognosis is independent of severity of cardiac disease (Meyer et al, 2015; Schopfer, Regan, Heidenreich, & Whooley, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome

Sanner

Grove

et al. 2018

Biological Research For Nursing

View full text Add to dashboard Cite

Depressive symptoms independently contribute to major adverse coronary events (MACEs), with the biological immune response to depression being a likely mediator of this relationship. To determine whether genetic- and/or gender-specific phenotypic differences contribute to associations among depressive symptoms, inflammatory response, and risk of MACE in patients with acute coronary syndrome (ACS), we conducted a prospective study of 1,117 ACS patients to test a gender-specific model in which depressive symptoms (Beck Depression Inventory-II [BDI-II]) are associated with risk of MACE. Cox proportional hazards models were used to model time to incident MACE and determine whether single-nucleotide polymorphisms (SNPs) in specific inflammatory protein-coding genes and depressive symptoms interact to influence levels of inflammatory proteins or risk of MACE. Females had significantly higher high-sensitivity C-reactive protein and monocyte chemoattractant protein-1 levels. Depression status differed by gender (29.9% of females and 21.1% of males had BDI-II scores indicative of depression [ p = .0014]). Depressive symptoms were associated with MACE; however, the interaction between these symptoms and gender was not significant. SNPs and depressive symptoms did not interact to influence inflammation or MACE. More females than males had BDI-II scores indicative of depression, yet the association between positive depressive symptom status and MACE did not vary by gender. Nor did the SNPs interact with depressive symptoms to influence inflammation or MACE. It remains of interest to identify a high-risk subgroup of ACS patients with genetic polymorphisms that result in immunoinflammatory dysregulation in the presence of depressive symptoms.

show abstract

Depressive Symptoms at Discharge from Rehabilitation Predict Future Cardiovascular-Related Hospitalizations

Cited by 8 publications

References 23 publications

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Childhood trauma and factors associated with depression among inpatients with cardiovascular disease

Longitudinal association between cognitive depressive symptoms and D‐dimer levels in patients following acute myocardial infarction

Effects of Gender-Specific Differences, Inflammatory Response, and Genetic Variation on the Associations Among Depressive Symptoms and the Risk of Major Adverse Coronary Events in Patients With Acute Coronary Syndrome

Contact Info

Product

Resources

About