Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study

Hanns, Laura; Cordingley, Lis; Galloway, James; Norton, Sam; Carvalho, Lívia A.; Christie, Deborah; Sen, Debajit; Carrasco, Roberto; Rashid, Amir; Foster, Helen; Baildam, Eileen; Chieng, Alice; Davidson, Joyce; Wedderburn, Lucy R.; Hyrich, Kimme L; Thomson, Wendy; Ioannou, Yiannis

doi:10.1093/rheumatology/key088

Cited by 66 publications

(73 citation statements)

References 42 publications

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“…[24][25][26][27][28][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] JIA subtype was described in 14 studies: 13 included polyarticular, [24][25][26]30,31,[35][36][37][38][39][40]45,46 11 included oligoarticular, 24,26,30,31,[35][36][37][38][39][40]46 10 included systemic, 25,26,30,31,[35][36][37][38]…”

Section: Population Characteristicsmentioning

confidence: 99%

“…Most studies that used validated screens for depressive symptoms reported prevalences of clinically significant symptoms in the range of 7-36% in children with JIA. [23][24][25][26]28,29,35,38,39,41,46,47 Reda et al used the MINI-KID psychiatric interview and reported that 93% of the patients had dysthymic disorder while 3% had major depressive disorder. 30 El Najjar et al found that all JIA patients scored above the cut-off for clinically significant symptoms on the CES-DC questionnaire.…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

“…42 While most studies reviewed did not analyze a differential prevalence of depressive symptoms based on age or gender, those that did agree with trends in the general population with older adolescents and females showing worse scores. 37,46,49 Prevalence Of Anxiety Symptoms In JIA…”

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

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<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Fair

Rodriguez

Knight

et al. 2019

OARRR

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Depression and anxiety are prevalent in children with rheumatologic diseases, including juvenile idiopathic arthritis (JIA). However, prevalence rates and the relationship with disease outcomes, including quality of life are conflicting in the early literature. To review the current literature, determine gaps in our knowledge, and identify areas in need of further investigation, we conducted a systematic review of studies examining depression and anxiety symptoms among children with JIA and the impact these symptoms may have on disease outcomes and quality of life. Six electronic databases were searched up until January 2019. Of 799 potential articles, 60 articles were included with the main focus on 28 articles from 2009 to 2019, to concentrate on the most current evidence. We found that JIA patients experience symptoms of depression and anxiety similar to other childhood chronic diseases and at higher rates than in healthy children. Patients who experience these symptoms have worse quality of life, with some evidence pointing to depression and anxiety symptoms having a greater impact on quality of life than other disease features, such as active joint count. Family members of JIA patients experience high rates of anxiety and depression symptoms which may impact their child's mental health and pain symptoms related to JIA. Conflicting reports of associations between depression/anxiety symptoms and disease features/disease outcomes and a paucity of longitudinal studies investigating the impact of treatment on mental health symptoms indicate areas in need of further research to effectively identify patients at greatest risk of depression and anxiety and to better understand how to treat and prevent these symptoms in youth with JIA. Family mental health should also be considered in investigations concerning mental health and disease outcomes of children with JIA.

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Section: Population Characteristicsmentioning

confidence: 99%

Section: Prevalence Of Depressive Symptoms In Jiamentioning

confidence: 99%

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<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Fair

Rodriguez

Knight

et al. 2019

OARRR

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“…Juvenile idiopathic arthritis (JIA) is the most common chronic acquired arthritis in children (Petty et al, ). The disease can impair both physical and psychosocial functions, resulting in developmental delays and chronic disability (Hanns et al, ; Magni‐Manzoni et al, ; Moorthy, Peterson, Hassett, & Lehman, ; Tollisen et al, ). Furthermore, emotional and school difficulties are major concerns in children with JIA (Bomba et al, ).…”

Section: Introductionmentioning

confidence: 99%

Health‐related quality of life in children with early‐stage juvenile idiopathic arthritis

Charuvanij

Chaiyadech

2019

Musculoskeletal Care

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Background Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease resulting in physical and psychological disability. This study aimed to measure the health‐related quality of life (HRQOL) and identify factors influencing the HRQOL. Methods We conducted a cross‐sectional study in Thai children with JIA and their parents between January and December 2015, using the Thai version of the Pediatrics Quality of Life (PedsQL) 4.0 generic core scale. Results Sixty‐five children (33 girls and 32 boys) were included. The median age of the children was 9.6 (interquartile range [IQR] 6.4–12.3) years and the median disease duration was 1.1 (IQR 0.2–2.2) years. The physical health subscale had the lowest score, with a median (range) of 78.1 (34.4–100). Twenty‐five (45.4%) children were classified as having suboptimal HRQOL. The school functioning subscale had the lowest score, at 60 (25–100) reported by parents. High disease activity and a disease duration <1 year were significantly associated with suboptimal HRQOL reported by parents, with adjusted odds ratios (ORs) of 20.2 (95% confidence interval [CI] 1.4, 291.7) and 5.9 (95% CI 1.2, 33.3), respectively. Conclusions Almost half of Thai children with JIA had suboptimal HRQOL. The physical health score was the lowest subscale reported by the children. Early, effective management of disease activity could improve the HRQOL in children with JIA.

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“…Chronic diseases tend to increase the risk for depressive symptoms, this was also shown in JIA, when actively screening for depressive symptoms (21). Chronic diseases tend to increase the risk for depressive symptoms, this was also shown in JIA, when actively screening for depressive symptoms (21).…”

Section: Discussionmentioning

confidence: 78%

Biologic Therapies in Polyarticular Juvenile Idiopathic Arthritis. Comparison of Long‐Term Safety Data from the German BIKER Registry

Klein

Becker

Minden

et al. 2019

ACR Open Rheumatology

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Objective. Biologics have an important role in the treatment of juvenile idiopathic arthritis (JIA). Long-term safety data are limited. Direct comparison of different agents regarding occurrence of adverse events (AEs), especially of rare events, requires large quantities of patient years. In this analysis, long-term safety with regard to AE of special interest (AESI) was compared between different biologics.Methods. Patients with nonsystemic JIA were selected from the German BIKER registry. Safety assessments were based on AE reports. Number of AEs, serious AEs, and 25 predefined AESIs, including medically important infection, uveitis, inflammatory bowel disease, cytopenia, hepatic events, anaphylaxis, depression, pregnancy, malignancy, and death, were analyzed. Event rates and relative risks were calculated using AEs reported after first dose through 70 days after last dose.Results. A total of 3873 patients entered the analysis with 7467 years of exposure to biologics. The most common AESIs were uveitis (n = 231) and medically important infections (n = 101). Cytopenia and elevation of transaminases were more frequent with tocilizumab (risk ratio [RR] 8.0, 95% confidence interval [CI] 4.2-15, and RR 4.7, 95% CI 1.8-12.2, respectively). Anaphylactic events were associated with intravenous route of administration. In patients ever exposed to biologics, eight malignancies were reported. Six pregnancies have been documented in patients with tumor necrosis factor inhibitors. No death occurred in this patient cohort during observation.Conclusion. Surveillance of pharmacotherapy as provided by the BIKER registry is an import approach, especially for long-term treatment of children. Overall, tolerance was acceptable. Differences between biologics were noted and should be considered in daily patient care.

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Depressive symptoms, pain and disability for adolescent patients with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study

Cited by 66 publications

References 42 publications

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

<p>Depression And Anxiety In Patients With Juvenile Idiopathic Arthritis: Current Insights And Impact On Quality Of Life, A Systematic Review</p>

Health‐related quality of life in children with early‐stage juvenile idiopathic arthritis

Biologic Therapies in Polyarticular Juvenile Idiopathic Arthritis. Comparison of Long‐Term Safety Data from the German BIKER Registry

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