Health‐related quality of life in children with early‐stage juvenile idiopathic arthritis

Abstract

Background Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease resulting in physical and psychological disability. This study aimed to measure the health‐related quality of life (HRQOL) and identify factors influencing the HRQOL. Methods We conducted a cross‐sectional study in Thai children with JIA and their parents between January and December 2015, using the Thai version of the Pediatrics Quality of Life (PedsQL) 4.0 generic core scale. Results Sixty‐five children (33 girls and 32 boys) were included. The median age of the children was 9.6 (interquartile range [IQR] 6.4–12.3) years and the median disease duration was 1.1 (IQR 0.2–2.2) years. The physical health subscale had the lowest score, with a median (range) of 78.1 (34.4–100). Twenty‐five (45.4%) children were classified as having suboptimal HRQOL. The school functioning subscale had the lowest score, at 60 (25–100) reported by parents. High disease activity and a disease duration <1 year were significantly associated with suboptimal HRQOL reported by parents, with adjusted odds ratios (ORs) of 20.2 (95% confidence interval [CI] 1.4, 291.7) and 5.9 (95% CI 1.2, 33.3), respectively. Conclusions Almost half of Thai children with JIA had suboptimal HRQOL. The physical health score was the lowest subscale reported by the children. Early, effective management of disease activity could improve the HRQOL in children with JIA.

Parent‐Reported Medication Side Effects and Their Impact on Health‐Related Quality of Life in Children With Juvenile Idiopathic Arthritis

“…When looking at the presence of SEs and their severity, we can note a clear impact on HRQoL. The lowered HRQoL of JIA patients has been previously established (2,27,28), and our study suggests that SEs play a role in this lowered HRQoL. Brunner et al showed that patients with a GISSK score of ≥2 had a significantly lower HRQoL than others without GI symptoms but similar disease activity (20).…”

Quality of life problems in children with juvenile idiopathic arthritis and its subtype associated with uveitis (literature review and own research)

“…Зважаючи на період, за який аналізувалися статті, більшість із них містила або інформацію з культурної адаптації валідизованих опитувальників, або подавала огляд проблеми оцінки якості життя. Але всі автори відзначають суттєве зниження показників якості життя у дітей з ЮІА [28][29][30][31][32].…”

“…У тайландському дослідженні, яке мало за мету оцінку якості життя, пов'язану зі здоров'ям дітей з ЮІА, автори відзначають, що отримані результати збігаються із загальновідомими щодо зниження якості життя таких дітей. Також збігаються дані щодо оцінки результатів шкали фізичного функціонування, через що автори рекомендували належним чи-ном відслідковувати ЯЖ дітей з ЮІА за допомогою PedsQL загального профілю та звертати особливу увагу на пацієнтів із субоптимальним показником якості життя [32].…”

A Study Protocol for the Management of Children With Juvenile Idiopathic Arthritis Based on ePROs

“…Consequently, there is a growing consensus among researchers and clinicians that ameliorating patient symptoms and improving HRQOL are the primary goals of the management of JIA ( 9 , 11 ). The constant monitoring of the JIA course (such as disease manifestations, therapies effects, morbidities, functional status, and quality of life) is a key way to achieve the goals.…”