Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats

Lopez-Navarro, AT; Ortega, María Peña; Peragón, Juan; Bueno, J. G.; Gil, Ángel; Sánchez–Pozo, Antonio

doi:10.1053/gast.1996.v110.pm8964401

Cited by 58 publications

(35 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that deprivation of NTs for certain periods may adversely affect protein synthesis in the liver and small intestine. 7 Moreover, NTs may reduce or inhibit the de novo synthesis of NTs in the liver through feedback systems. In our study, AST and ALT were decreased without an abnormal liver, which was assumed that NTs could promote restoration and optimize liver function.…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence that dietary nucleotides (NTs) affect different aspects of body function and health, including lipid metabolism, 1 immune function, [2][3][4][5] intestinal microbiota, 6 liver function and morphology 7 as well as growth performance. 8 Although nucleotides can be synthesized de novo, several tissues with a rapid turnover rate, such as the intestine, may benefit from an exogenous supply to save energy.…”

Section: Introduction Nmentioning

confidence: 99%

See 1 more Smart Citation

Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

et al. 2013

Journal of Medicinal Food

View full text Add to dashboard Cite

The aim of the present study was to evaluate dietary effects of dietary nucleotides (NTs) on developmental parameters in second-generation Sprague-Dawley rats. Experimental design was set up as six groups, including one control and five nucleotide administered groups, doses ranged from 0.01% to 1.28% nucleotides. First-generation (F0) rats were divided into two terms: (1) fed for 90-day study; (2) mated for offspring (F1). After weaning, each group of second-generation F1 rats was fed the control diet. Evaluating parameters were weight gain and food utilization ratios of rats, hematological and biochemical parameters, and organ pathology. The results showed that there was a greater weight gain and food utilization ratio in weaned rats (F0 and F1). Furthermore, weight gain and food utilization ratios were increased in the first 2 weeks of F1 male and the first week of F1 female rats. There were no significant changes in blood indicators of NT groups with the exception of decrease in aspartate aminotransferase and serum uric acid levels. Overall, it was demonstrated that NT supplements could promote the early growth and development at a 0.01% dose. Although NTs may have cumulative reproductive effects, they were safe even at a high-dose supplementation. Additionally, NT supplementation could promote restoration and optimize liver function.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introduction Nmentioning

confidence: 99%

Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

et al. 2013

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…It was suggested to explain part of the effect of kidney bean feeding on the small and large intestine [27] when compared with low fi ber diets. The increase in microfl ora activity is also known to increase the production of other factors which could also be involved in intestinal development, namely polyamine [33] and nucleic acid [34,35] . Lectins have also been described as growth-promoting factors in the small intestine [36][37][38] , but they are heat-labile and cooking is known to destroy most of their activity [39,40] .…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Cooked Common Bean (<i>Phaseolus vulgaris</i>) and Lentil (<i>Lens esculenta puyensis</i>) Feeding on Protein and Nucleic Acid Contents in Intestines, Liver and Muscles in Rats

Pirman¹,

Combe²,

Mirand³

et al. 2004

Ann Nutr Metab

View full text Add to dashboard Cite

Aim: Our aim was to investigate the influence of legume feeding on the protein and nucleic acid content of intestinal tissues and muscles. Methods: Growing male Wistar rats were fed ad libitum on balanced diets containing cooked common bean or lentil as the unique protein source (180 g·kg^–1 dry matter) for 20 days. The control group was pair-fed with an iso-energetic, iso-nitrogenous balanced casein diet. Results: Intestinal tissues were heavier in the legume-fed groups and higher relative mass (g per 100 g body mass) of protein, RNA and DNA were found in these tissues as compared to those of the control groups. In liver protein and RNA masses were significantly lower in the bean group than in the control group but the DNA content was not different in the legume and in the control groups. In gastrocnemius and soleus muscles, there was no significant effect of legume feeding on the fresh mass and on the protein and RNA contents, but the DNA content of the m. gastrocnemius was significantly lower in both legume groups than in their control group. The ribosomal capacity of intestines, liver and muscles was not significantly affected by legume feeding. Conclusion: Legume feeding had a trophic effect on both proximal and distal intestinal tissues; dietary fiber appears to be the main cause of this effect.

show abstract

“…internalization of membrane transporters to sub-cellular storage vesicles) has been shown to be a regulatory mechanism for CNT2 in several cell lines including adrenal chromaffin cells, reticulocytes and cholangiocytes [56][57][58] . Although CNT1 has been shown to be up-regulated in intestine and down-regulated in hepatocytes of pyrimidinefree diet fed animals, the dietary effects of adenosine on CNT2 activity and molecular expressions are not known [59,60] . Several studies have shown that nucleoside transport functions and expressions are regulated by hormones [61][62][63][64][65][66] .…”

Section: Regulation Of Adenosine Transport and Cnt2 Expression In Genmentioning

confidence: 99%

Adenosine: An immune modulator of inflammatory bowel diseases

Ye¹,

Rajendran²

2009

WJG

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a common and lifelong disabling gastrointestinal disease. Emerging treatments are being developed to target inflammatory cytokines which initiate and perpetuate the immune response. Adenosine is an important modulator of inflammation and its anti-inflammatory effects have been well established in humans as well as in animal models. High extracellular adenosine suppresses and resolves chronic inflammation in IBD models. High extracellular adenosine levels could be achieved by enhanced adenosine absorption and increased de novo synthesis. Increased adenosine concentration leads to activation of the A2a receptor on the cell surface of immune and epithelial cells that would be a potential therapeutic target for chronic intestinal inflammation.Adenosine is transported via concentrative nucleoside transporter and equilibrative nucleoside transporter transporters that are localized in apical and basolateral membranes of intestinal epithelial cells, respectively. Increased extracellular adenosine levels activate the A2a receptor, which would reduce cytokines responsible for chronic inflammation.

show abstract

Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats

Cited by 58 publications

References 12 publications

Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

Developmental Effects of Dietary Nucleotides in Second-Generation Weaned Rats

Differential Effects of Cooked Common Bean (<i>Phaseolus vulgaris</i>) and Lentil (<i>Lens esculenta puyensis</i>) Feeding on Protein and Nucleic Acid Contents in Intestines, Liver and Muscles in Rats

Adenosine: An immune modulator of inflammatory bowel diseases

Contact Info

Product

Resources

About