Depth of tumor invasion in locally advanced rectal cancer correlates with patients’ prognosis: The usefulness of elastic stain for its measurement

Katsumata, Daisuke; Fukui, Hirokazu; Ono, Yuko; Ichikawa, Kazuhito; Tomita, Shigeki; Imura, Johji; Abe, Akihito; Fujita, Masanori; Watanabe, Osamu; Tsubaki, Masahiro; Sunagawa, Masakatsu; Fujimori, Takahiro

doi:10.1007/s00595-007-3608-3

Cited by 23 publications

(16 citation statements)

References 14 publications

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“…In addition, the prognostic significance of the MED in rectal cancer was advocated in several articles. [1][2][3][4][5]11 Cawthorn et al 4 demonstrated that the patients with mesorectal extension of more than 4 mm had lower overall survival rate (<4 mm; 55% vs ≥4 mm; 25%, p < 0.001), but their study had some limitations in that they included the patients with rectal cancer without mesorectal invasion (stage I) and those who had undergone palliative surgery.…”

Section: Discussionmentioning

confidence: 99%

Depth of Mesorectal Extension Has Prognostic Significance in Patients With T3 Rectal Cancer

Shin

Jeong

Yoo

et al. 2012

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 99%

Depth of Mesorectal Extension Has Prognostic Significance in Patients With T3 Rectal Cancer

Shin

Jeong

Yoo

et al. 2012

Diseases of the Colon &Amp; Rectum

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“…The area of invasion by these tumors, however, broadly encompasses the subserosa just past the muscularis propria to the peritoneal stroma subjacent to the serosal surface. Deeply invasive pT3 tumors, however, exhibit more aggressive behavior than shallower tumors, and the wide range in the depth of invasion among pT3 tumors may in part account for their clinicopathologic heterogeneity and disparate clinical outcomes [5,26–28]. The visceral peritoneum is anatomically and ontologically distinct from the organ which it invests, and tumor invasion of the peritoneum may result in changes in the tumor microenvironment with altered regulation of tumor progression [12,29–31].…”

Section: Discussionmentioning

confidence: 99%

Histopathology and enhanced detection of tumor invasion of peritoneal membranes

Chen

Melissa²

2017

PLoS ONE

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Tumor invasion of the peritoneal membrane may have an adverse prognostic significance, but its histopathologic features can be diagnostically difficult to recognize. We observed that local peritoneal injury associated with tumor invasion is characterized by activation and proliferation of serosal stromal cells that express cytokeratin, a characteristic property of injured serosal membranes that may have diagnostic utility. To explore this, we examined 120 primary tumors of the gastrointestinal tract and pancreaticobiliary system using cytokeratin and elastic stains to assess for tumor invasion of peritoneal membranes. Peritoneal invasion by tumor was associated with retraction, splaying, and destruction of the elastic lamina and proliferation of keratin-expressing stromal cells of serosal membranes. All 82 peritoneal invasive tumors were characterized by neoplastic cells that invaded the elastic lamina and the serosal connective tissue with neoplastic cells that abutted or were surrounded by keratin-positive stromal cells, whereas all 38 tumors limited to the subserosa showed none of these features. The diagnosis of tumor invasion of peritoneal membranes is enhanced by the combined use of cytokeratin and elastic stains, which in turn would enable better histopathologic correlation with patient treatment and outcome.

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“…Cases of carcinoma of the lung, stomach, liver, gallbladder, and pancreas associated with the production of granulocyte-colony stimulating factor (G-CSF) have been reported. [1][2][3][4][5][6] Granulocytecolony stimulating factor-producing tumors are associated with an increase in the white blood cell count, rapid disease progression, and a poor prognosis. Moreover, the number of reports of tumors producing G-CSF is increasing.…”

Section: Introductionmentioning

confidence: 99%

Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: Report of a case

et al. 2009

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We report a rare case of granulocyte-colony stimulating factor (G-CSF)-producing undifferentiated carcinoma of the ascending colon. A 52-year-old Japanese man presented with a rapidly growing, aggressive abdominal tumor, and severe leukocytosis (63 000/mm(3)). The serum level of G-CSF was remarkably elevated to 640 pg/ml (normal, <18.1 pg/ml). The patient underwent palliative cytoreductive surgery for ascending colon carcinoma with lymph node and liver metastases. Histological examination revealed an undifferentiated carcinoma of the ascending colon. The tumor cells were positive for G-CSF on immunohistochemical staining. The leukocyte counts and G-CSF level decreased after surgery. Thus, we diagnosed G-CSF-producing colon carcinoma. His general condition deteriorated rapidly and he died of residual tumor growth on postoperative day 24.

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Depth of tumor invasion in locally advanced rectal cancer correlates with patients’ prognosis: The usefulness of elastic stain for its measurement

Abstract: The depth of tumor invasion beyond the MP is thus considered to be an important prognostic factor for patients with T3/T4 rectal carcinoma, especially in the lower rectum. A careful follow-up is required for the patients with rectal carcinoma that has invaded more than 4 mm beyond the MP.

Cited by 23 publications

References 14 publications

Depth of Mesorectal Extension Has Prognostic Significance in Patients With T3 Rectal Cancer

Depth of Mesorectal Extension Has Prognostic Significance in Patients With T3 Rectal Cancer

Histopathology and enhanced detection of tumor invasion of peritoneal membranes

Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: Report of a case

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