Der Einflu� des Prednison- und Prednisolonbisguanylhydrazons auf die Na+ + K+-stimulierte Membran-ATPase des Meerschweinchenherzens

Dransfeld, H.; Greeff, K.

doi:10.1007/bf00247048

Cited by 22 publications

(3 citation statements)

References 11 publications

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“…Dransfield and Greff [6] reported that prednisone could alter in vitro Na% K -ATPase activity in RBC. But this does not provide an explanation for the discrepancy between our results and those of Cole and Maletz [4] and Cole et al [5] whose patients were also taking prednisone and azathio prine.…”

Section: Discussionmentioning

confidence: 99%

Cation Transport in Erythrocytes of Patients with Renal Failure

Zannad¹,

Royer²,

Kessler³

et al. 1982

Nephron

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Na⁺, K⁺-ATPase activity in erythrocytes (RBC) has been assessed indirectly by the ⁸⁶Rb uptake method in 10 patients with acute renal failure (ARF), 11 patients with chronic renal failure (CRF) on haemodialysis and 13patients treated by kidney transplantation, and compared to age-matched healthy controls. In each patients, the sensitivity of ⁸⁶Rb uptake to digoxin (IC₅₀) has been measured. Na⁺, K⁺-ATPase activity was decreased in patients with ARF and in patients with CRF but not in transplanted patients. IC₅₀ was lowered in transplanted patients. The implications of these findings are discussed in terms of possible mechanisms of the changes in Na⁺, K⁺-ATPase activity in RBC of patients with renal failure.

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Section: Discussionmentioning

confidence: 99%

Cation Transport in Erythrocytes of Patients with Renal Failure

Zannad¹,

Royer²,

Kessler³

et al. 1982

Nephron

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“…OAc 12 * OH A receptor sites on cell membranes (Dransfeld & Greeff, 1964;Dransfeld, Galetke & Greeff, 1967;Greeff & Schlieper, 1967;Yamamoto, Akera & Brody, 1978a, b). It is unlikely that a steroid conjugate of this type exists in nature.…”

Section: Discussionmentioning

confidence: 99%

“…Prednisolone, on the other hand, is completely inactive. PBGH is known to possess inotropic activity on the isolated heart (Kroneberg, Meyer, Schraufstaetter, Schuetz & Stoepel, 1964;Greeff & Schlieper, 1967;Schuetz, Meyer & Kraetzer, 1969), and, like ouabain, to inhibit (Na+ + K+)-ATPase and to compete with ouabain (Dransfeld & Greeff, 1964;Dransfeld, Galetke & Greeff, 1967;Greeff & Schlieper, 1967;Yamamoto, Akera & Brody, 1978a, b). It is unlikely that a steroid conjugate of this type exists in nature.…”

Section: Discussionmentioning

confidence: 99%