Der Einfluß der elektronischen Oberflächeneigenschaften auf die Wechselwirkung zwischen Fibrinogen und Festkörpern

Rzany, A.; Leistner, Tom; Steiner, J.; Bolz, A.; Schaldach, M.

doi:10.1515/bmte.1998.43.s1.388

Cited by 3 publications

(4 citation statements)

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“…3 Bolz et al showed that after interaction of sheep erythrocytes with the a-SiC:H surface the hemoglobin concentration, which is increased when erythrocytes are damaged, is similar to the concentration found after interaction with saline solution indicating that amorphous silicone carbide is harmless to red blood cells. 27 In addition, histological evaluation of the vascular anatomy of a porcine arterial blood vessel after implantation of a-SiC:H coated Palmaz-Schatz stent showed no thrombus formation (Fig. 3).…”

Section: Silicon Carbide (A-si-c:h) Coated Stentsmentioning

confidence: 88%

“…However, different materials with the same surface roughness affect the clotting mechanism differently, which indicates that thrombosis is also caused by electrochemical interactions of blood coagulation proteins with the surface of the implants. 27 An electron transfer from the protein solution (blood) to the metallic surface induces thrombogenesis at artificial surfaces. 28 The conversion of the hemoprotein fibrinogen to fibrin, which is due to an electron transfer, is the important irreversible step of the plasmatic and solid state induced blood clotting.…”

Section: Stents Coated Via Chemical or Physical Vapour Deposition Tecmentioning

confidence: 99%

“…Thin films of amorphous hydrogenated silicon carbide (a-SiC:H) or amorphous hydrogenated carbon (a-C:H) can be produced by this technology using C 2 H 2 -SiH 4 gas mixtures. 27,30,31 The latter also known as diamond-like carbon (DLC) coating, is of growing interest for this purpose due to its bio-and hemocompatible nature.…”

Section: Stents Coated Via Chemical or Physical Vapour Deposition Tecmentioning

confidence: 99%

“…506; B 1006 3 Histologic studies of porcine arterial blood vessel after implantation of a-SiC:H coated Palmaz-Schatz stents showed no thrombus formation: sensitive endothelial layer was completely preserved (reproduced with permission from A. Bolz)27 …”

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confidence: 99%

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Review of stent coating strategies: Clinical insights

Sydow-Plum¹,

Tabrizian²

2008

Materials Science and Technology

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Despite advances in stent design, expansion techniques and anti-thrombotic agents to improve pharmacological control of subacute thrombosis (SAT) and to reduce to 2 the occlusive thrombosis rates, a significant risk of mortality associated with thrombotic vascular occlusion due to the adhesion of blood constituents remains a problem for patients with more complex lesions. The adhesion process is greatly governed by the surface characteristics, mainly the surface chemical composition, surface morphology, presence of charge, surface wettability and surface roughness. Surface chemical inertness (reduced interaction with chemicals and biological components) subsequently became the primary criteria which guided the development of non thrombotic stents as well as other blood-contacting materials. A number of strategies have been adopted in an effort to coat the stent with or without the use of a drug delivery system, to overcome the thrombus formation, to minimize the stent occlusion and to improve the overall hemocompatibility of the device. This paper aims at reviewing the clinical outcomes of main nonpharmaceutical stent coating procedures and their clinical outcomes. New stents which combine the anti-thrombotic coating with the drug delivery ability, such as radioactive stents, degradable stents and some new challenging trends which are mostly at research and development stage for stent surface coatings are also introduced.

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Section: Silicon Carbide (A-si-c:h) Coated Stentsmentioning

confidence: 88%

Section: Stents Coated Via Chemical or Physical Vapour Deposition Tecmentioning

confidence: 99%