Der Einfluß von Chlormethiazol (Distraneurin) auf das Schlaf-Elektroenzephalogramm nach Alkoholdelir

Maxion, H; Schneider, Elke

doi:10.1055/s-0028-1094277

Cited by 4 publications

(4 citation statements)

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“…Chlormethiazole (salt), 2 g (i.e. 4 tablets) has been shown to suppress REM sleep (11); this effect was also noted in our study and may be of value in the treatment of delirium tremens (12).…”

Section: Discussionsupporting

confidence: 82%

The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers

Liljenberg

Almqvist

Broman

et al. 1986

Acta Psychiatr Scand

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Chlormethiazole has sedative, hypnotic and anticonvulsant properties, and is used in the treatment of sleep disorders and confusion in the elderly. In this study we examined the effects of chlormethiazole on EEG recorded sleep in six normal volunteers aged 67-74 years. After baseline registration, chlormethiazole (base), 384 mg p.0. (i.e. 2 capsules)*, was administered during 5 nights followed by one withdrawal registration. Sleep latency decreased from 52 to 27 min during the treatment period ( P < 0.01) and increased to 57 min during withdrawal. Wakeful periods during sleep decreased from 106 to 62 min during the treatment period and increased during withdrawal to 104 min ( P < 0.001). The sleep efficiency improved slightly during chlormethiazole treatment. The distribution of the sleep stages was essentially unaffected by chlormethiazole. According to subjective assessment the subjects rated their ability to fall asleep and their sleep quality as significantly better during the drug period. Based on sleep recordings and subjective ratings, there was no evidence of rebound insomnia on withdrawal. Psychoperformance tests revealed no evidence of hangover effects.

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Section: Discussionsupporting

confidence: 82%

The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers

Liljenberg

Almqvist

Broman

et al. 1986

Acta Psychiatr Scand

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“…The simultaneous testing with alcohol intake as covariate reduced the test power so that contrasts between the two groups became nonsignificant. Maxion and Schneider [26] have presented similar findings for clomethiazole. Interestingly, also in the placebo group REM sleep percentage increased at T1 compared to T0, though this change did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 54%

“…Data on the effects of clomethiazole on the sleep EEG of healthy subjects or alcohol dependent patients are scarce. In an early study, Maxion and Schneider [26] observed an increase of slow wave sleep (SWS) and a suppression of REM sleep in alcohol dependent patients taking clomethiazole to treat delirium tremens.…”

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confidence: 99%

Polysomnography During Withdrawal with Clomethiazole or Placebo in Alcohol Dependent Patients - A Double-Blind and Randomized Study

Gann

Feige²,

Cloot³

et al. 2004

Pharmacopsychiatry

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The REM sleep results are in line with earlier findings that REM sleep disinhibition in primary alcohol dependency is partly due to a REM sleep rebound after withdrawal from medication. Differences in the polysomnographic variables of sleep continuitiy and sleep architecture at T0 and T1 found between the clomethiazole and the placebo patients correspond to rebound insomnia following discontinuation of clomethiazole. Our findings indicate that drugs enforcing GABAergic neurotransmission may perpetuate the neuroadaptative effects caused by chronic alcohol consumption.

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“…Konsistent mit der Hypothese,dass das GABAerge System bei den Schlafstörun-gen von Alkoholabhängigen involviert ist, ist der Befund,dass GABA-Agonisten wie Benzodiazepine und Clomethiazol bei abstinenten Alkoholabhängigen die totale Schlafzeit erhöhen und REM-Schlaf supprimieren [9,41,78]. Für weitere GABAAgonisten wie THIP und GHB konnte bei gesunden jungen Männern eine SWS-för-dernde Wirkung gezeigt werden [30,109].…”

Section: Neurobiologie Des Schlafs Und Der Alkoholabhängigkeit -Theraunclassified

Die Bedeutung des Schlafs für gesunde Alkoholkonsumenten und alkoholabhängige Patienten

et al. 2004

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This article deals with the effects of alcohol on sleep and sleep EEG of healthy individuals and alcohol-dependent patients during different phases of alcohol dependency. Healthy individuals initially experience an improvement in sleep, although a greater quantity of alcohol can lead to problems of sleep maintenance during the second half of the night. Pre-existing sleep deprivation or sleep restriction potentiates the effects of alcohol. Alcohol-dependent patients are found to be more prone to sleep problems than healthy individuals, which can facilitate the development of alcoholism. These patients experience difficulty falling asleep and suffer from a reduced total sleep time during all phases of the disorder, often accompanied by other sleep disorders such as sleep apnea syndrome or periodic leg movements during sleep. Certain predictors for the risk of relapse in abstinent alcoholics have been identified. Neurobiological findings in sleep and alcohol dependency are discussed. The cholinergic-aminergic reciprocal interaction model of REM and non-REM sleep regulation is significant in this context. Therapeutic implications are discussed.

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Der Einfluß von Chlormethiazol (Distraneurin) auf das Schlaf-Elektroenzephalogramm nach Alkoholdelir

Cited by 4 publications

References 0 publications

The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers

The effects of chlormethiazole in EEG recorded sleep in normal elderly volunteers

Polysomnography During Withdrawal with Clomethiazole or Placebo in Alcohol Dependent Patients - A Double-Blind and Randomized Study

Die Bedeutung des Schlafs für gesunde Alkoholkonsumenten und alkoholabhängige Patienten

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