Der Reaktionsverlauf bei der Umsetzung von Anthranilamid mit Lactonen

On the Synthesis and Reactivity of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-ones

“…All these observations taken in combination agree with the report that the system can be cyclised through two competing mechanisms. 19 We suggest that use of stronger bases, such as potassium tert-butoxide, favours deprotonation of the secondary amide in 7 followed by 5-exo-tet cyclisation and subsequent condensation of the lactam with the primary amide (route A). However, when the chain length increases the lactamisation is slower.…”

Ir(I)‐Catalyzed Synthesis of (E)‐4‐Benzylidenylacridines and (E)‐2‐Styrylquinoline‐3‐carboxamide through Sequential Suzuki–Miyaura Coupling, Dehydrogenative Friedländer Reaction, and sp3‐C–H Activation

“…Several acridines, quinolines, and their derivatives are known to possess biological activities, as summarized in Figure . For instances, antiprotozoal (A 1 ), antimalarial (A 2 ), (A 13 ), anticancer (A 3 ), (A 14 ),DNA‐targeting acridines (A 4 ), antimicrobial (A 5 ), antitumour (A 6 ), (A 10 ), Anti HIV (A 7 ), (A 15 ), antibacterial (A 8 ), antiproliferative (A 9 ), antileishmanial (A 11 ), antifungal (A 12 ), antitubercular (A 16 ), antiplatelet (A 17 ) activity. Various methods were developed for the synthesis of quinolines and acridines in the past few decades, such as the Friedländer synthesis, Skraup synthesis, and Doebner‐von Miller synthesis .…”