1983
DOI: 10.1182/blood.v61.5.1017.bloodjournal6151017
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Derivation of lymphoma cell lines from microscopically normal bone marrow in patients with undifferentiated lymphomas: evidence of occult bone marrow involvement

Abstract: Evidence is presented that at least 17% of microscopically normal bone marrow samples obtained from patients with undifferentiated lymphomas contain occult tumor cells. Of 19 microscopically normal bone marrow samples tested, continuous tumor cell lines were obtained from 4. A tumor cell origin was confirmed by the presence of an 8;14 chromosomal translocation in each case, and HLA typing confirmed the patient origin of the cell line. In two other patients, direct cytogenetic examination of microscopically nor… Show more

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Cited by 3 publications
(3 citation statements)
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“…Occult disease in the bone marrow of non-Hodgkin's lymphoma patients can be missed even when great care is exercised. Benjamin et al [14] showed that undifferentiated lymphomas can have submicroscopic bone marrow involvement even when the usual biopsy and aspirate studies are normal. They cultured cell lines with 8;14 chromosomal translocations from four of 19 marrow samples that were microscopically normal.…”
Section: Discussionmentioning
confidence: 99%
“…Occult disease in the bone marrow of non-Hodgkin's lymphoma patients can be missed even when great care is exercised. Benjamin et al [14] showed that undifferentiated lymphomas can have submicroscopic bone marrow involvement even when the usual biopsy and aspirate studies are normal. They cultured cell lines with 8;14 chromosomal translocations from four of 19 marrow samples that were microscopically normal.…”
Section: Discussionmentioning
confidence: 99%
“…Clonogenic culture assays detect not only whether malignant cells are present but also if the cells have the ability to induce relapse in the patient. A number of studies has demonstrated that clonogenic malignant cells could be grown from morphologically normal BM [3–, 5]. Patients with non‐Hodgkin's lymphoma (NHL) who were infused with autologous marrow containing lymphoma cells that could be grown in culture had an increased incidence of relapse [6].…”
Section: Methods For Detection Of Mrdmentioning
confidence: 99%
“…Five cell lines derived from African Burkitt's lymphoma patients were obtained from other laboratories (DAUDI, NAMALVA, HRI +2, RAJI, and AK778). Methods of derivation and documentation of the tumor origin of these cell lines have been previously reported [19]. The surface markers and Ig secretion data obtained in these cell lines correlate with that of the original tumors [20,2 11.…”
Section: Cell Linesmentioning
confidence: 99%