Derivatives of Piperazine. IV. Reactions with Derivatives of Monochloroacetic Acid

Bisintercalating Threading Diacridines: Relationships between DNA Binding, Cytotoxicity, and Cell Cycle Arrest

“…1,4-Bis(aminoethyl)piperazine, required for the C2pipC2 linker, was prepared from piperazine, as outlined in Scheme . Piperazine was reacted with chloroethanenitrile in the presence of sodium carbonate to give piperazino-1,4-bis(ethanenitrile) in quantitative yield .…”

“…The combined filtrate was condensed to about 40 mL and then cooled on ice. 1,4-Bis(ethanenitrile)piperazine crystallized from the solution as white needles (3.47 g, 85%), mp 165−166 °C (lit . mp 165 °C).…”

1,2,4-Triazoles: Synthetic approaches and pharmacological importance. (Review)

“…During the last decade, several piperazine derivatives were synthesized as useful chemotherapeutic agents for various diseases, such as Crivixan® (Indinavir sulphate) [175][176][177] and delaviridine (Rescriptor) [178], powerful inhibitors for the protease and reverse transcriptase inhibitor of HIV enzymes, respectively. On the basis of the exciting biological results of the piperazine derivatives, several substituted 1,2,4-triazole derivatives carrying piperazine residue, 143 and 145 [179], have been synthesized from cycloaddition of 93 with the 1,4-bis(cyanomethyl)piperazine 142 [180] and 1-cyanomethyl-4-methylpiperazine 144 [181], respectively (Scheme 33). Compounds 143 and 145 were screened against breast, lung, and CNS cancers, as well as their DNA affinity assay.…”

Supramolecular structure of the 1:2 complex of 1,4-dimethylpiperazine mono-betaine with squaric acid

“…The piperazine ring has a chair conformation with the N(4)ZCH 3 (38) and in the 1:1 complex with p-hydroxybenzoic acid (8), whereas in the 1:2 complex of MBPZ with 3-iodobenzoic acid both NZCH 3 groups occupy the equatorial positions (10).…”

“…N-alkylation reactions of piperazine and 1,4-dimethylpiperazine yield symmetrically and asymmetrically substituted derivatives. The reaction pathway depends on the reaction conditions (2)(3)(4)(5)(6)(7). Recently, we have studied hydrogen-bonded complexes of 1-carboxymethyl-1,4-dimethylpiperazinium inner salt (1,4-dimethylpiperazine mono-betaine, MBPZ) and 1,4-dicarboxymethyl-1,4-dimethylpiperazinium inner salt (1,4-dimethylpiperazine di-betaine) with HCl (7), p-hydroxybenzoic acid (8,9), 3-iodobenzoic acid (10) and L-and meso-tartaric acids (11)(12)(13).…”