Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

Nicu, Carina; O'Sullivan, James D B; Ramos, Raúl; Timperi, Ludovica; Lai, Tiffany; Farjo, Nilofer; Farjo, Bessam; Pople, Jenny; Bhogal, Ranjit; Hardman, Jonathan A.; Plikus, Maksim V.; Ansell, David M.; Paus, Ralf

doi:10.1016/j.jid.2020.12.019

Cited by 44 publications

(28 citation statements)

References 79 publications

(63 reference statements)

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“…For example, hepatocyte growth factor (HGF) secreted by dermal white adipose tissue activates the Wnt/β-catenin signalling pathway and enhances the pigmentation of hair follicles by upregulating the expression of AXIN2, LEF-1, Wnt10b, and Wnt6. 191 In addition, O3,4,5-tri-caffeoylquinic acid enhances pigmentation by activating β-catenin in follicular melanocytes and upregulating the expression of MITF, a target gene, in caffeoylquinic acid. 192 …”

Section: Function Of the Wnt/β-catenin Pathway In Diseasesmentioning

confidence: 99%

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu

Xiao

et al. 2022

Sig Transduct Target Ther

982

390

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The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.

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Section: Function Of the Wnt/β-catenin Pathway In Diseasesmentioning

confidence: 99%

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Liu

Xiao

et al. 2022

Sig Transduct Target Ther

982

390

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“…With recent insights into the impact of neurotransmitters (e.g., acetylcholine) released by sympathetic nerve fibers innervating the bulge, as in murine HF melanocyte stem cells, 76 a tissue context‐dominated perspective on examining the role of melatonin in human pigmentation and melanocyte physiology has become even more important, but also more complex. Such a tissue context perspective must include the skin mesenchyme, since additional inputs on pigmentation originate from dermal fibroblasts in the human EPU, 72,73 inductive fibroblasts in the HF's dermal papilla, and perifollicular dermal white adipose tissue which secrete HFPU‐ and melanogenesis‐stimulatory hepatocyte growth factor 77,78 . These mesenchymal inputs rhythmically switch HF pigmentation on and off in a strictly hair cycle‐dependent manner, with induction of HF melanocyte apoptosis during each phase of HF regression (catagen) and reconstruction of a new HFPU during each re‐entry into the phase of active hair growth (anagen) from resident progenitor cells 69,79 .…”

Section: Introductionmentioning

confidence: 99%

Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective

Sevilla

Chéret

Slominski

et al. 2022

Journal of Pineal Research

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The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators by its versatility of functions and mechanisms of action, which include the regulation of vertebrate pigmentation. Although first discovered through its potent skin‐lightening effects in amphibians, melatonin's role in human skin and hair follicle pigmentation and its impact on melanocyte physiology remain unclear. Synthesizing our limited current understanding of this role, we specifically examine its impact on melanogenesis, oxidative biology, mitochondrial function, melanocyte senescence, and pigmentation‐related clock gene activity, with emphasis on human skin, yet without ignoring instructive pointers from nonhuman species. Given the strict dependence of melanocyte functions on the epithelial microenvironment, we underscore that melanocyte responses to melatonin are best interrogated in a physiological tissue context. Current evidence suggests that melatonin and some of its metabolites inhibit both, melanogenesis (via reducing tyrosinase activity) and melanocyte proliferation by stimulating melatonin membrane receptors (MT1, MT2). We discuss whether putative melanogenesis‐inhibitory effects of melatonin may occur via activation of Nrf2‐mediated PI3K/AKT signaling, estrogen receptor‐mediated and/or melanocortin‐1 receptor‐ and cAMP‐dependent signaling, and/or via melatonin‐regulated changes in peripheral clock genes that regulate human melanogenesis, namely Bmal1 and Per1. Melatonin and its metabolites also accumulate in melanocytes where they exert net cyto‐ and senescence‐protective as well as antioxidative effects by operating as free radical scavengers, stimulating the synthesis and activity of ROS scavenging enzymes and other antioxidants, promoting DNA repair, and enhancing mitochondrial function. We argue that it is clinically and biologically important to definitively clarify whether melanocyte cell culture‐based observations translate into melatonin‐induced pigmentary changes in a physiological tissue context, that is, in human epidermis and hair follicles ex vivo, and are confirmed by clinical trial results. After defining major open questions in this field, we close by suggesting how to begin answering them in clinically relevant, currently available preclinical in situ research models.

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“…FGF7, a member of the FGF family, is an important factor that leads to hair follicle proliferation and differentiation [ 54 , 55 ]. Well-known angiogenesis-related growth factors, VEGF, FGF2, and HGF, can stimulate hair follicle proliferation [ 11 , 33 , 38 , 56 , 57 , 58 ]. At both the gene and protein levels, VEGF levels increased significantly.…”

Section: Discussionmentioning

confidence: 99%

Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

Hyun

Kim

et al. 2021

Pharmaceutics

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Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of Morus alba activates β-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with M. alba root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of β-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.

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Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

Cited by 44 publications

References 79 publications

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective

Morus alba Root Extract Induces the Anagen Phase in the Human Hair Follicle Dermal Papilla Cells

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