Dermal Amyloid Deposits in Disseminated Superficial Porokeratosis

Garcia-F-Villalta, María J.; Daudén, Esteban; Ruíz‐Genao, Diana; Fraga, Javier; García‐Diez, Amaro

doi:10.1080/00015550310007076

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Eosinophilic amyloid deposition in the papillary dermis was noted in several reported cases, preferably at their inflammatory stages (both inside the annular edge and beneath the cornoid lamellae) in both sun-protected and sun-exposed areas, as a consequence of keratinocyte degeneration [84,[254][255][256][257][258][259][260][261][262][263][264][265][266]. These can be stained using Congo red, pagoda red, thioflavin T or methyl violet and exhibit bright yellow fluorescence under a polarised microscope [255,258,[260][261][262][263]. This phenomenon is likely underreported [263,266].…”

Section: Pathologymentioning

confidence: 99%

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

Pietkiewicz,

Korecka,

Salwowska

et al. 2023

Metabolites

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Porokeratosis is a heterogeneous group of keratinising disorders characterised by the presence of particular microscopic structural changes, namely the presence of the cornoid lamella. This structure develops as a consequence of a defective isoprenoid pathway, critical for cholesterol synthesis. Commonly recognised variants include disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis of Mibelli, palmoplantar porokeratosis (including porokeratosis palmaris et plantaris disseminata and punctate porokeratosis), linear porokeratosis, verrucous porokeratosis (also known as genitogluteal porokeratosis), follicular porokeratosis and porokeratoma. Apart from the clinical presentation and epidemiology of each variant listed, this review aims at providing up-to-date information on the precise genetic background, introduces imaging methods facilitating the diagnosis (conventional and ultraviolet-induced fluorescence dermatoscopy, reflectance confocal microscopy and pathology), discusses their oncogenic potential and reviews the literature data on the efficacy of the treatment used, including the drugs directly targeting the isoprenoid–mevalonate pathway.

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