Dermatitis due to mitomycin C bladder instillations: study of 2 cases

Arregui, M.A.; Aguirre, A.; Gil, N.; Goday, J.J.; Ratón, Juan Antonio

doi:10.1111/j.1600-0536.1991.tb01754.x

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…The patch test concentration and vehicle we used are considered non-irritant (2). The positive patch test to mitomycin C proves a Type IV allergic reaction, as in previous reports (2)(3)(4)(5). In our case, a single exposure to the drug was required for sensitization and systemic contact dermatitis was subsequently elicited by the small dose of mitomycin on the patch.…”

Section: Discussionsupporting

confidence: 62%

“…In Canada, acetarsone is available only in Neo-Vagex® tablets, a broad-spectrum preparation directed at mixed vaginitis. Each vaginal tablet contains: acetarsone I 00 mg; clioquinol 50 mg; benzalkonium chloride 2 mg; lactic acid; and lactose Absorption of acetarsone through the vaginal mucosa has resulted in I case of fatal arsenical poisoning (4). Hypersensitivity reactions, with generalized eruptions occasionally progressing to exfoliative dermatitis, have also been described (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

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Generalized contact dermatitis from acetarsone

Sasseville¹,

Carey

Singer

1995

Contact Dermatitis

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Section: Discussionsupporting

confidence: 62%

mentioning

confidence: 99%

Generalized contact dermatitis from acetarsone

Sasseville¹,

Carey

Singer

1995

Contact Dermatitis

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“…Mitomycin C is an antitumor antibiotic used for chemotherapy of superficial bladder cancers by intravesical instillation. Contact allergy to mitomycin C, from intravesical as well as from local application, has been described by several authors (1)(2)(3)(4)(5)(6)(7)(8). Mitomycin C, administered intravesically, is absorbed systemically and may lead to systemic contact dermatitis (1).…”

mentioning

confidence: 99%

Type III and Type IV hypersensitivity reactions due to mitomycin C

2000

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A 71-year-old man developed an exfoliative dermatitis of the palms of the hands and soles of the feet, and a generalized itch, during treatment with intravesical instillations of mitomycin C for an undifferentiated carcinoma of the bladder. Patch tests with mitomycin C 0.03%, 0.1% and 0.3% aq. were positive. Because of the serious consequences of this finding, the patient was retested with mitomycin C in pet. (same concentrations), a more stable preparation. This showed clear positive reactions. During this last series of patch tests, he developed palpable purpura on the legs. We postulated that this reaction was an immune-complex-mediated reaction, caused by the 2nd series of patch tests with mitomycin C. To prove this, we performed histopathological and immunofluorescence investigations, and these showed the reaction to be consistent with Henoch-Schonlein-type purpura. We therefore conclude that this patient developed systemic reactions to mitomycin C, characterized by an eczematous dermatitis as well as purpuric reactions. The intravesical installations with mitomycin C have been stopped. The patient's skin problems (the purpura as well as the eczema) have completely resolved and have not recurred.

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“…1 8 Strukturformel von Mitomycin C mitteln (DKG-Block 5) durch. Parallel getestet wurde Mitomycin C (Mito-medac ® ), das in NaCl verdünnt in Konzentrationen von 0,1% (entsprechend der Einsatzkonzentration von 20 mg/ml), 0,01% und 0,001% appliziert wurde.…”

Section: Epikutantestungenunclassified

“…Mittel der Wahl zur differenzialdiagnostischen Einordnung sind Epikutantestungen, für die von mehreren Autoren Protokolle beschrieben wurden [1,3,4,7,8,10,17]: Geeignet erscheinen Testkonzentrationen zwischen 0,001 und 0,1%, die in Serien mit insgesamt ca. 30 gesunden Kontrollpersonen keine Hautreizungen hervorgerufen haben [1,7]. Als Lösungsmittel können Aqua, NaCl oder auch Vaseline verwendet werden, wobei Mitomycin C in Vaseline am stabilsten zu sein scheint [4,8].…”

Section: Introductionunclassified

Hämatogenes Kontaktekzem nach intravesikaler Instillation von Mitomycin C

et al. 2007

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Mitomycin C is an alkylating chemotherapeutic agent which is instilled intravesically to prevent recurrence of superficial bladder carcinomas. After several cycles of mitomycin C, our patient developed a pruritic genital dermatitis and palmar desquamation. Following exclusion of a fungal infection, we performed patch tests using the standard series, the major basic ointment ingredients, disinfectants, and mitomycin C in concentrations of 0.001 to 0.1%; the resulting diagnosis was allergic contact dermatitis due to delayed-type hypersensitivity to mitomycin C. The skin rash rapidly resolved with application of topical steroids, and the intravesical chemotherapy was changed to doxorubicin. Eczematous skin reactions are quite common side effects after intravesical instillation of mitomycin C. In the majority of cases, they are caused by delayed-type hypersensitivity reactions, presumably elicited by hematogenous spread of the allergen, and not by irritation. The sensitization most likely occurs via the bladder mucosa. In order to differentiate between allergic and toxic contact dermatitis, patch tests with the above-mentioned mitomycin C concentrations are useful. In cases of mild allergic contact dermatitis the intravesical chemotherapy might be continued with concomitant topical steroids.

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Dermatitis due to mitomycin C bladder instillations: study of 2 cases

Cited by 13 publications

References 9 publications

Generalized contact dermatitis from acetarsone

Generalized contact dermatitis from acetarsone

Type III and Type IV hypersensitivity reactions due to mitomycin C

Hämatogenes Kontaktekzem nach intravesikaler Instillation von Mitomycin C

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