Dermatitis Herpetiformis in an Infant

Castrow, Fred F.

doi:10.1001/archderm.1970.04000050095014

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…On histology, subepidermal blisters are seen which are indistinguishable from those of dermatitis herpetiformis or bullous pemphigoid (Bean& Jordon, 1974). Early immunofluorescence studies, both direct and indirect, reported negative findings (Jordon et al, 1970;Castrow & Chernosky, 1970). Those earlier studies, however, were incomplete as the skin was not examined for IgA.…”

Section: Benign Chronic Bullous Dermatosis Of Childhood (Syn Juvenilmentioning

confidence: 99%

The chronic acquired bullous diseases of childhood

Marsden¹,

Skeete²,

Black³

1979

Clin Exp Dermatol

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Due to their rarity, the chrotiic acquired bullous diseases of childhood have not yet beeti studied in detail. Constant changes in terminology and classification have so far achieved little apart from confusing clinicians. We have attempted, therefore, to interpret the literature, to define the diseases in question and have included some case reports of patients seen recently at St John's Hospital for Diseases of the Skin. The pemphigus groupWhen pemphigus occurs in children, the disease is chtiically, histologically and immunologically similar to that in adults. Beutner & Chorzelski (1976) reviewed 234 cases of pemphigus and found that the disease began before the age of 10 in four cases and between 11 and 20 years in nine. Eleven of these cases were female, an incidence 5-5 times higher than in other age groups, where the sexes are equally affected. This female preponderance in children with pemphigus has been noted elsewhere (Jordon et al, 1976). It is of interest that a much larger proportion of affected children had pemphigus foliaceus or erythematosus (sis out of thirteen cases) compared with adults (twenty-seven out of 221 cases).

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Section: Benign Chronic Bullous Dermatosis Of Childhood (Syn Juvenilmentioning

confidence: 99%

The chronic acquired bullous diseases of childhood

Marsden¹,

Skeete²,

Black³

1979

Clin Exp Dermatol

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Chronic Bullous Dermatosis of Childhood

Esterly¹,

Furey²,

Kirschner³

et al. 1977

Arch Dermatol

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Bullous Eruption in a Child

Ranlett¹

1989

Arch Dermatol

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A 3\m=1/2\-year-old white girl presented with a 6-day history of a rash and fever. The fever resolved after 48 hours, but the rash, which was vesiculobullous and hemorrhagic, had become more extensive. The patient was initially thought to have atypical varicella with secondary bacterial infection and was treated with oral oxacillin sodium and diphenhydramine hydrochloride. She was the product of a normal pregnancy and delivery without previous developmental or medical problems.Results of the physical examination were normal except for the cutaneous findings. There were multiple tense vesicles and bullae filled with clear to hemorrhagic fluid and crusted lesions distributed over the scalp, face, neck, trunk, and all extremities. The vesicles ranged in size from 3 mm to 2 cm and were pruritic, and many were arranged along the borders of erythematous or crusted patches (Fig 1).Biopsy of an intact early vesicular lesion revealed a subepidermal bulla with edema of adjacent papillary dermis and a mild mixed inflammatory infiltrate with eosinophils and neutrophils (Figs 2 and 3).Direct immunofluorescence performed on lesional and perilesional skin revealed a linear deposition of IgA along the dermoepidermal junction, while no staining was noted for IgG, IgM, C3, or C4 (Fig 4).

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Dermatitis Herpetiformis in an Infant

Cited by 7 publications

References 4 publications

The chronic acquired bullous diseases of childhood

The chronic acquired bullous diseases of childhood

Chronic Bullous Dermatosis of Childhood

Bullous Eruption in a Child

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