Dermatofibrosarcoma protuberans of the breast: a case report

Sin, Francesca Nga-yee; Wong, Kwok-Wai

doi:10.1016/j.clinimag.2011.04.004

Cited by 20 publications

(25 citation statements)

References 12 publications

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“…Selective or superselective lymphadenectomy is not important. As in the present case, pathological analysis reveals spindle cells arranged in storiform patterns and short fascicles (2,10) that are CD34-positive (3,10,11). Postoperative recurrence has been associated with the index of cell division, cell structure, and incisal margin (12).…”

Section: Discussionsupporting

confidence: 73%

“…DFSP is also often reported in the limbs, head and neck; however, involvement of the breast is rare, as described previously (8). Typically, DFSP develops as a deep-red or blue-red plaque and grows slowly, usually reaching a size of ≥3 cm (2). …”

Section: Discussionmentioning

confidence: 99%

“…Typically, DFSP starts as a red or blue-red coloured nodules. Nodules may gradually develop to become irregularly shaped swellings (2). The five-year survival rate can reach 88.9%.…”

Section: Introductionmentioning

confidence: 99%

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Dermatofibrosarcoma protuberans of the breast: A case report

et al. 2014

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Dermatofibrosarcoma protuberans (DFSP) is a rare, metastasizing tumor of the deep dermis and subcutaneous tissue. While it frequently occurs in the trunk and extremities, breast involvement has rarely been reported. In the present case, imaging and pathological technologies were used to detect DFSP of the breast. Surgical excision with wide margins (>3 cm) and pathology revealed spindle cells arranged in storiform patterns and short fascicles which were crucially CD34-positive, enabling a definitive diagnosis prior to surgery.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Dermatofibrosarcoma protuberans of the breast: A case report

et al. 2014

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“…Patients often ignore these tumors due to their slow growth. DFSP breast involvement is rare, and is often misdiagnosed as a benign breast tumor, which delays treatment (3–5). In the present study, a case report of a woman with locally advanced DFSP of the breast is discussed.…”

Section: Introductionmentioning

confidence: 99%

Dermatofibrosarcoma protuberans of the breast: A case report

et al. 2017

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Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth. The tumor occurs in patients of all ages, with the highest frequency occurring between the second and the fifth decades of age. Genetically, DFSP is characterized by a reciprocal translocation t(17;22)(q22;q13), or more often, as a supernumerary ring chromosome involving chromosomes 17 and 22. Standard treatment of a localized tumor is surgical excision with wide margins. In the present study, a case report of a 43-year-old woman with a growing tumor in the left breast is discussed. The patient underwent breast-conserving surgery. Histological and cytogenetic examinations of the tumor resulted in a diagnosis of DFSP. The clinical and morphological characteristics of the tumor, in addition to the treatment options, were also evaluated.

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“…Clinically it is usually seen as a small red-brown nodule localized in the dermis. As the lesion progresses, it forms swelling on the skin surface, infiltrates through subcutaneous adipose tissue, muscles and bones thus forming a multinodular, hard, fixed mass with ulcerated and hemorrhagic areas (3,4). Recurrence has been reported in some cases despite wide local excision (3).…”

Section: Introductionmentioning

confidence: 99%

A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

Ozcan¹,

Hacıhasanoğlu²,

Nazli³

et al. 2016

J Breasth Health

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Dermatofibrosarcoma protuberans is a slow-growing, local aggressive fibrous tumor of the subcutaneous tissue, frequently seen in the proximal extremities and the trunk. Its occurrence in the breast is very rare. Herein, we present a female who presented with a breast mass, and aim to discuss pathological features and differential diagnosis of dermatofibrosarcoma protuberans. A 44-year-old female presented to our clinic with a mass on her breast. Physical examination revealed a 8x5.5 cm mass with multilobular nodules on the skin in the lower inner quadrant of her right breast. Her mammography revealed a hyperdense, 7.5x6.5 cm, well-demarcated, lobulated mass in the right breast, which caused nodules on the lower paraareolar portion of the breast skin. There was no axillary lymphadenopathy on both clinical and radiologic examinations. A core needle biopsy had been performed prior to her referral to our center, which revealed a 'spindle cell lesion'. The patient underwent simple mastectomy. On macroscopic examination; the skin over the lesion appeared ulcerated, and there was a well-defined solid mass, which was pale white-tan on the cut surface. Microscopic examination revealed monotonous spindle cell proliferation arranged in storiform pattern within the collagenous stroma with irregular extensions into deep adipose tissue. There were no necrosis or nuclear pleomorphism. The mitotic rate was 2-3/10 HPF. Immunohistochemically tumor cells showed diffuse CD34 positivity, and S100, EMA and SMA negativity. Based on histopathological and immunohistochemical findings, the lesion was diagnosed as dermatofibrosarcoma protuberans. Local recurrence is expected in 20-50% of these cases. Its treatment requires complete surgical excision with wide margins. Distant metastases, although rare, have been reported.

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Dermatofibrosarcoma protuberans of the breast: a case report

Cited by 20 publications

References 12 publications

Dermatofibrosarcoma protuberans of the breast: A case report

Dermatofibrosarcoma protuberans of the breast: A case report

Dermatofibrosarcoma protuberans of the breast: A case report

A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

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