Dermatofibrosarcoma Protuberans of the Neck: A Brief Review of the Literature

Felek, Sevim Aslan; Ibas, Mustafa; Dursun, Songül; Heper, Aylin Okçu

doi:10.1007/s12070-018-1314-7

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…However, it rarely causes regional or distant metastases 12,13 . Although the etiology is unclear, some authors reported that it may develop from trauma, burn or surgery scar tissues 14 . Microscopically, it extends far beyond the assessed clinical margins, spreading in the dermis and subcutaneous tissue 15 .…”

Section: Discussionmentioning

confidence: 99%

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Longo

D’Orsi

Orlando

et al. 2022

PRRS

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Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with high propensity for local recurrence. We present a case of a 53-yearold woman with a recurrent DFSP of the clavicular region. The patient underwent extensive local excision including the external cortical bone of the left clavicle. The resulting large defect was reconstructed using pedicled Latissimus Dorsi myocutaneous flap. The histopathological examination confirmed dermatofibrosarcoma protuberans with clear surgical margins and the patient was satisfied with the final aesthetic result.

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Section: Discussionmentioning

confidence: 99%

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Longo

D’Orsi

Orlando

et al. 2022

PRRS

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“…As a result, its clinicopathological features are poorly understood, furthermore, there is also no specific treatment strategy. Although sporadic cases have been reported, seldom relevant systematic clinical studies on HNDFSP have been conducted so far (Ali et al, 2012; Felek et al, 2019; Ong et al, 2013; Sartore et al, 2015). Whether the clinicopathological characteristics, prognosis after surgical treatment, and expression of clinically relevant indicators of HNDFSP are different from those of DFSP in other sites a still unknown.…”

Section: Introductionmentioning

confidence: 99%

Head‐and‐neck dermatofibrosarcoma protuberans: Survival analysis and Clinically relevant immunohistochemical indicators

Dai

Zhang

et al. 2023

Oral Diseases

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BackgroundHead and neck dermatofibrosarcoma protuberans (HNDFSP) is extremely rare and not entirely understood.ObjectiveTo investigate the clinicopathological features of HNDFSP and identify the expression of its clinically relevant indicators, with the expectation of improving the existing treatment strategies.MethodsA long‐term follow‐up of patients with HNDFSP who received treatment between 2000 and 2021 at Shanghai Ninth People's Hospital was conducted. The clinical, histological, and immunohistochemical data of the patients were retrieved and analyzed. The endpoint of the study was the incidence of significant disease‐related clinical events (recurrences or metastasis).ResultsA total of 49 patients with HNDFSP were included in the study, with males (92.7%) predominating than females (7.3%). Eighteen patients developed recurrent disease (36.8%) after surgery, and the median time of recurrence was 48 months (interquartile, 20–74 months). Metastasis occurred in two cases (4.1%). Two patients died during follow‐up, both with local recurrence, and one of them with intestinal metastasis. Post‐operation radiotherapy was administered to eight patients (16.3%) and the effect in local control was remarkable. Age, tumor size, and negative margins with sufficient safety width were the main independent factors affecting the disease‐free survival. Several potential targeted therapeutic indicators, including EZH2 (80.0%), EGFR (91.4%), PDGF (97.1%), PD‐L1 (77.1%), and VEGF (77.1%), were positively expressed in most tumor samples.ConclusionHNDFSP is rare, significantly challenging to control locally, and has a worse prognosis with current treatment strategies. Wide local excision and long‐term follow‐up are needed. Radiotherapy could improve the prognosis of patients with HNDFSP.

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Unmasking dermatofibrosarcoma protuberans: Case report of an atypical presentation complicated by post-surgical excision

Zhou

Chin

Strutin³

et al. 2020

International Journal of Surgery Case Reports

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Dermatofibrosarcoma Protuberans of the Neck: A Brief Review of the Literature

Cited by 5 publications

References 11 publications

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Recurrent Dermatofibrosarcoma Protuberans of the Clavicular Region: Radical Excision and Reconstruction With Latissimus Dorsi Myocutaneous Flap

Head‐and‐neck dermatofibrosarcoma protuberans: Survival analysis and Clinically relevant immunohistochemical indicators

Unmasking dermatofibrosarcoma protuberans: Case report of an atypical presentation complicated by post-surgical excision

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