Dermatologic manifestation of diabetes

Levy, Lauren; Zeichner, Joshua

doi:10.1111/j.1753-0407.2011.00151.x

Cited by 61 publications

(47 citation statements)

References 93 publications

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“…69 Disorders can often result in areas of thickened skin, reduced skin elasticity, and reduced blood flow. 70 If large enough areas of skin are affected, such legions could theoretically impact the body's ability to cool itself through effective SkBF and sweating.…”

Section: Skin Disordersmentioning

confidence: 99%

Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?

Yardley

Stapleton

Sigal

et al. 2013

Diabetes Technology & Therapeutics

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Chronic medical conditions such as type 2 diabetes may alter the body's normal response to heat. Evidence suggests that the local heat loss response of skin blood flow (SkBF) is affected by diabetes-related impairments in both endothelium-dependent and non-endothelium-dependent mechanisms, resulting in lower elevations in SkBF in response to a heat or pharmacological stimulus. Thermoregulatory sweating may also be diminished by type 2 diabetes, impairing the body's ability to transfer heat from its core to the environment. Diabetes-associated co-morbidities and the medications (particularly those affecting fluid balance) required to treat these conditions may exacerbate the risk of heat-related illness by decreasing SkBF and sweating further. Unfortunately, the majority of studies measure local heat loss responses in the hands and feet and lack measures of core temperature. Therefore, the impact of these impairments on whole-body heat loss remains unknown. This review addresses heat-related vulnerability in individuals with type 2 diabetes by examining the literature related to heat loss responses in this population. Type 2 diabetes, its associated co-morbidities, and the medications required in their treatment may cause dehydration, lower SkBF, and reduced sweating, which could consequently impair thermoregulation. This effect is most evident in individuals with poor blood glucose control. Although type 2 diabetes can be associated with impairments in SkBF and sweating, more physically active individuals requiring fewer medications and having good blood glucose control may be able to tolerate heat as well as those of similar age and body composition.

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Section: Skin Disordersmentioning

confidence: 99%

Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?

Yardley

Stapleton

Sigal

et al. 2013

Diabetes Technology & Therapeutics

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“…Some treatment options include steroids, methotrexate, and ultraviolet light phototherapy (15,52). Differential diagnosis includes Sclerederma Buschke, also associated with type 1 diabetes.…”

Section: Sclerederma Diabeticorummentioning

confidence: 99%

Cutaneous Manifestations of Diabetes Mellitus

Vinnarasan¹,

Subbaiya²,

Vinothiney³

et al. 2017

jemds

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“…Skin damage due to a wound, burn or illness may lead to major complications, such as diabetic ulcers, psoriasis and bed sores [1]–[3]. For example, approximately one third of patients with diabetes mellitus suffer from cutaneous manifestations of the disease including non-healing ulcers [4].…”

Section: Introductionmentioning

confidence: 99%

Tracking Dynamic Microvascular Changes during Healing after Complete Biopsy Punch on the Mouse Pinna Using Optical Microangiography

et al. 2013

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Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and chronic microvascular and tissue responses upon an injury in vivo. A tissue wound was induced using a 0.5 mm biopsy punch on a mouse pinna. The changes in the microangiography, blood flow velocity and direction were quantified for the acute (<30 min) wound response and the changes in the tissue structure and microangiography were determined for the chronic wound response (30 min–60 days). The initial wound triggered recruitment of peripheral capillaries, as well as redirection of main arterial and venous blood flow within 3 min. The complex vascular networks and new vessel formation were quantified during the chronic response using fractal dimension. The highest rate of wound closure occurred between days 8 and 22. The vessel tortuosity increased during this time suggesting angiogenesis. Taken together, these data signify that OMAG has the capability to track acute and chronic changes in blood flow, microangiography and structure during wound healing. The use of OMAG has great potential to improve our understanding of vascular and tissue responses to injury in order to develop more effective therapeutics.

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Dermatologic manifestation of diabetes

Cited by 61 publications

References 93 publications

Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?

Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?

Cutaneous Manifestations of Diabetes Mellitus

Tracking Dynamic Microvascular Changes during Healing after Complete Biopsy Punch on the Mouse Pinna Using Optical Microangiography

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