Dermatological Diseases Associated with Pregnancy: Pemphigoid Gestationis, Polymorphic Eruption of Pregnancy, Intrahepatic Cholestasis of Pregnancy, and Atopic Eruption of Pregnancy

Abstract

Dermatoses unique to pregnancy are important to recognize for the clinician as they carry considerable morbidity for pregnant mothers and in some instances constitute a risk to the fetus. These diseases include pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. This review discusses the pathogenesis, clinical importance, and management of the dermatoses of pregnancy.

European S2k Guideline on Chronic Pruritus

“…It is a hormonally triggered, reversible cholestasis occurring in late pregnancy (late second or third trimester) in genetically predisposed women. The prevalence is around 1%, but varies: it is higher in Scandinavia, South America and South Africa (118). The aetiopathogenesis is multifactorial and involves genetic, hormonal and environmental factors such as seasonal variability and dietary factors (119).…”

Skin changes during pregnancy. Is that an important issue for pregnant women?

“…Recent classification of specific pregnancy dermatoses includes polymorphic eruption of pregnancy, atopic eruption of pregnancy, gestational pemphigoid and intrahepatic cholestasis [2]. The last two are quite rare, but may influence pregnancy outcome and pose a risk for foetal health [3]. Moreover, pregnancy may modify the course of numerous pre-existing dermatological conditions [4,5].…”

Pemphigoid gestationis: Clinical and histologic features of twenty-three patients

“…Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare pregnancy-associated autoimmune disease ( Kanwar, 2015 , Sävervall et al, 2015 ). Skin lesions usually begin as pruritic and urticarial papules and plaques that rapidly become vesicular ( Cobo et al, 2009 ).…”