Dermatological effects of Nigella sativa

Aljabre, Salih H.M.; Alakloby, Omar M.; Randhawa, Mohammad Akram

doi:10.1016/j.jdds.2015.04.002

Cited by 81 publications

(83 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nigella sativa (N. sativa) belongs to the botanical family of Ranunculaceae and commonly grows in Eastern Europe, Middle East, and Western Asia (14,15). The most important bioactive compounds of N. sativa include alkaloids, thymoquinone, riboflavin, pyridoxine, niacin, folic acid, proteins, and minerals (14,15).…”

Section: Introductionmentioning

confidence: 99%

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

Ranjbaran

Abediankenari

Amiri

2018

Iran Red Crescent Med J

View full text Add to dashboard Cite

Background: With regards to the high potential of medicinal plants in the production of biopharmaceuticals, one can rely on the promising prospect of insulin production via plant resources. Objectives: This study was conducted with the aim of using plant extract for insulin-producing cells. Methods: This was a quasi-experimental study using critical case sampling. Six samples were gathered from the umbilical cord (Wharton's jelly) in a governmental university affiliated hospital, Sari, Iran in 2017 after successful isolation of mesenchymal stem cells. Initially, Nigella sativa seeds extraction was performed to prepare the extract for cellular differentiation. Next, dithizone (DTZ) staining was used to evaluate insulin production, and insulin level was examined by the enzyme-linked immunosorbent assay (ELISA). Data were analyzed was analyzed with the SPSS version 16 software using independent sample t-test.

show abstract

Section: Introductionmentioning

confidence: 99%

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

Ranjbaran

Abediankenari

Amiri

2018

Iran Red Crescent Med J

View full text Add to dashboard Cite

show abstract

“…In the latter case the oil of the black seed exhibited a strong activity as compared to the antischistosomal and anthelmintic drug for domestic animals, prazequantel; wherein it produced a potentiating effect with the co-treatment 3 . Moreover, Simalango and Utami [13] suggested that the ethanol extract of NS (0.5-8%) has significant anti-Ascaris suum activity.…”

Section: Ns Against Parasitesmentioning

confidence: 98%

“…It exhibits synergistic effects with streptomycin and gentamycin, while additive with spectinomycin, erythromycin, tobramycin, doxycycline, chloramphenicol, nalidixic acid, ampicillin, lincomycin and co-trimoxazole and similar to topical mupirocin. Moreover, NS has potent inhibitory activity against antibiotic resistant microorganisms, including many multi-drug-resistant (MDR) gram positive and gram negative bacteria [3]. According to Manju et al [10] the EO from NS is able to protect Artemia spp.…”

Section: Ns Against Bacteriamentioning

confidence: 99%

“…The TQ also acted against Trichophyton spp., Epidermophyton spp., and Microsporum spp. In addition TQ, thymohydroquinone and thymol are also demonstrated to have an antifungal effect against many clinical isolates, including dermatophytes, molds and yeasts [3]. Furthermore, the NS seed oil (10-200 μg/mL) was found to act against Saccharomyces cerevisiae and C. utilis [12].…”

Section: Ns Against Fungimentioning

confidence: 99%

“…To date (March 2016) in the databases such as PubMed/Medline, Science Direct, Web of Science, Scopus, and google, a total of 1290 published evidences were found on the following topics: morphology of the plant, isolated compounds and their derivatives, and pharmacological activities. One general revision of this plant was done by Ahmad et al [2], following to a dermatological revision by Aljabre et al [3], an immunomodulatory and anti-inflammatory revision by Majdalawieh and Fayyad [4], an anti-inflammatory, antioxidant, an immunomodulatory [5], male fertility [6], metabolic parameters in diabetes mellitus [7], and thymoquinone and its therapeutic potentials by Darakhshan et al [8]. This review summarizes the above mentioned studies.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Islam¹

2016

Adv. Biomed. Pharma.

View full text Add to dashboard Cite

Nigella sativa L. (NS) has a number of important biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anti-viral, anti-parasitic and anti-protozoal, cytotoxic, anticancer, neuro-, gastro-, cardio-, hetapto-and nephroprotective activities. In addition, the NS exerts beneficiary effects on reproductive, pulmonary and immune systems as well as in diabetes mellitus (DM), fertility (male and female), breast cancer, dermatological complications, dehydration, dyspepsia, and osmotic balance and so on. Among the isolated constituents, thymoquinone (TQ) is a vastly studied phytochemical in NS. A number of reports suggest that, the NS may be one of the potential herbs in health promotion. This review paper will discuss the detailed and mechanistic aspects of the biological activity of N. sativa along with the reported phytoconstituents.

show abstract

The effect of a hydrogel made byNigella sativaL. on acne vulgaris: A randomized double‐blind clinical trial

Soleymani

Zargaran

Farzaei

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

Nigella sativa L. (black seed) is one of the main medicinal plants frequently cited in traditional Persian medicine manuscripts for management of acne vulgaris. The present study was designed to investigate the efficacy of a topical preparation from N. sativa in acne vulgaris. In a randomized double-blind controlled clinical trial, 60 patients (30 patients in treatment and 30 in placebo group) were randomly received N. sativa hydrogel (standardized based on thymoquinone) or placebo hydrogel, twice daily for 60 days. The Investigator's Global Assessment (IGA) grading score was recorded for each patient. Moreover, acne disability index (ADI) was evaluated using a standard questionnaire filled out by the patients at the beginning and end of the study. A 78% mean reduction in the IGA score on the N. sativa-treated group was recorded compared with 3.3% on the vehicle-treated one. Significant reductions in the number of comedones, papules, and pustules were observed in the treatment group compared with placebo after 2 months. Also, ADI was decreased 63.49% in the treatment versus 4.5% in the placebo groups. No adverse event was recorded. N. sativa hydrogel had significant effects on improving the symptoms of acne vulgaris with acceptable tolerability.

show abstract

Dermatological effects of Nigella sativa

Cited by 81 publications

References 29 publications

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

Enhanced Differentiation of Wharton’s Jelly-Derived Mesenchymal Stem Cells in Insulin-Producing Cells by the Extract of Nigella sativa Seeds

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

The effect of a hydrogel made byNigella sativaL. on acne vulgaris: A randomized double‐blind clinical trial

Contact Info

Product

Resources

About