Dermatological medications and local therapeutics

Schaefer, Christof; Kirtschig, Gudula

doi:10.1016/b978-0-12-408078-2.00018-4

Cited by 6 publications

(5 citation statements)

References 98 publications

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“…Moreover, the authors observed its efficiency in diminishing hyperpigmentation. The effectiveness of azelaic acid in decreasing hyperpigmentation has been confirmed in many studies and for this reason the acid is widely used in cosmetology and dermatology 25–28 . Moreover, some studies have reported the role of this compound in the reduction of post‐inflammatory hyperpigmentation, or hyperpigmentation caused by phototoxic reactions 29,30 .…”

Section: Discussionmentioning

confidence: 87%

“…The effectiveness of azelaic acid in decreasing hyperpigmentation has been confirmed in many studies and for this reason the acid is widely used in cosmetology and dermatology. [25][26][27][28] Moreover, some studies have reported the role of this compound in the reduction of post-inflammatory hyperpigmentation, or hyperpigmentation caused by phototoxic reactions. 29,30 In turn, PA is an alpha-hydroxy acid used mainly for skin exfoliation and lightening.…”

Section: (Cheek)mentioning

confidence: 99%

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Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Markiewicz‐Tomczyk

Budzisz

Erkiert‐Polguj

2022

J of Cosmetic Dermatology

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Introduction Vitamins C, E, and A and substances of plant origin, including azelaic acid and phytic acid are frequently used in cosmetic preparations to counteract oxidative stress and negative effects of free radicals. The aim of the study was to evaluate a novel combined therapy consisting of azelaic acid, ascorbic acid, and phytic acid applied layer on layer. Methods Twenty study participants received a series of eight treatments performed every 7 days. Twenty percent azelaic acid and then 30% phytic acid were applied to the entire face, while 40% l‐ascorbic acid only on the left side. The preparations were applied layer by layer. Skin parameters were measured before the series of treatments (T0), after the series of eight treatments (T1–8 weeks), and 1 month after the end of the treatment (T2–12 weeks). Results The application of two and three active compounds resulted in a significant improvement in erythema and hyperpigmentation both on the forehead and the cheeks, however, more pronounced effects were observed when all the three active compounds were used. Both applied types of treatment considerably increased skin moisture. All the participants (100%) were satisfied with the effects of the treatment. A majority of them reported an improvement in skin hydration, firmness, and elasticity, more uniform skin tone and a reduction of skin redness and wrinkles. Conclusions Topical application of these active compounds resulted in improvement of skin elasticity and flexibility, reduction of wrinkles, hyperpigmentation, erythema, and telangiectasia as well as amelioration of skin tone.

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Section: Discussionmentioning

confidence: 87%

Section: (Cheek)mentioning

confidence: 99%

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Markiewicz‐Tomczyk

Budzisz

Erkiert‐Polguj

2022

J of Cosmetic Dermatology

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“…It has antibacterial, anti‐inflammatory, and keratolytic properties, making it effective in acne therapy and skin pigmentation issues, especially in darker skin types. As a tyrosinase inhibitor, it reduces melanin synthesis and is an alternative to hydroquinone 34,35 . Cassiaside C (compound 72) falls into the class of naphthopyranone glycosides, torososide B (compound 73) belongs to oligosaccharides, and rheinoside C (compound 74) is categorized as an anthracene derivative, with deprotonated molecular ions at m/z 595.1659, 931.2757, and 593.1512, respectively.…”

Section: Resultsmentioning

confidence: 99%

Untargeted metabolomic profiling of Prinsepia utilis Royle leaves by Ultra‐Performance Liquid Chromatography‐Quadrupole‐Time of Flight‐Mass Spectrometry

Chauhan,

Bhalla,

Bhadoriya

et al. 2024

J Mass Spectrom

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Prinsepia utilis Royle, native to the Himalayas, is esteemed in Chinese and Indian folk medicine for its diverse medicinal benefits, targeting arthritis, pain relief, bone disorders, and joint discomfort. This study examined the 25% aqueous methanol extract of P. utilis leaves using UPLC‐Q‐TOF‐MS/MS, identifying 78 metabolites, 76 of which were reported for the first time in P. utilis. These included 64 phenolics represented by 56 flavonoids, 5 phenolic acids, 3 phenolic glycosides, 4 terpenoids, 2 lignan glycosides, and 8 other compounds, expanding the knowledge of its chemical composition. These findings lay a foundation for further research, providing insights into potential bioactive compounds and opening avenues for applications in natural product drug discovery, traditional medicine, and nutraceutical development, leveraging the plant's established traditional uses.

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“…14 Although the medication is systemically absorbed, it undergoes complete metabolism to benzoic acid, a commonly used food additive. 15,16 Benzoic acid has low bioavailability, as it gets rapidly metabolized by the kidneys; therefore, benzoyl peroxide is unlikely to reach clinically significant levels in the maternal circulation and consequently the fetal circulation. Additionally, it has a low risk for causing congenital malformations.…”

Section: Topical Treatments For Acnementioning

confidence: 99%

Acne and Pregnancy: A Clinical Review and Practice Pearls

Yaghi

2024

Cutis

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Acne vulgaris is a common condition that routinely affects females of childbearing age. Taking into consideration the reproductive journey of women when treating acne is of paramount importance given the safety concerns to both the mother and the fetus associated with certain medications. Therefore, careful consideration of therapeutic choices during pregnancy is crucial. Herein, we summarize the safety of acne treatments during pregnancy and offer practical clinical pearls for routine dermatology practice.

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Dermatological medications and local therapeutics

Cited by 6 publications

References 98 publications

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Untargeted metabolomic profiling of Prinsepia utilis Royle leaves by Ultra‐Performance Liquid Chromatography‐Quadrupole‐Time of Flight‐Mass Spectrometry

Acne and Pregnancy: A Clinical Review and Practice Pearls

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