Dermatomyositis and duodenal carcinoid

Agarwal, Vikas; Sachdev, Atul; Punia, Rajpal Singh

doi:10.1007/s10067-004-0921-8

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…When the contents of Sorbus torminalis extracts are compared, it has been reported that chlorogenic acid, which is one of the compounds found in ethanol/water extract more than other bioactive compounds, stops the development of breast cancer cells and suppresses cell migration and invasion by stimulating apoptosis [16] . Unlike other extracts, it has been reported that the application of procyanidin, another prominent active ingredient in ethanol/water extract, has a cytotoxic or growth‐inhibitory effect on MCF‐7 [70] and MDA‐MB‐468 [71] cell lines, which are breast cancer cells. In another study, procyanidin C1 showed better selective cytotoxicity against MDA‐MB‐ 231 cell lines and MCF‐7 cell lines.…”

Section: Resultsmentioning

confidence: 99%

Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications

Ak,

Tüfekci,

Mustafa

et al. 2024

Chemistry & Biodiversity

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Sorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S. torminalis leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS‐MS. The effects of the extracts on cell viability were investigated using the MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) method against MDA‐MB‐231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p < 0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin‐3,5‐diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5‐dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n‐hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of S. torminalis on antimicrobial, biofilm inhibitory, and anticancer activities was examined. Based on outcomes of our study recognize this plant as a critical source of medically active chemicals for feasible phytopharmaceutical and nutraceutical applications, providing the first scientific insight into the detailed biological and chemical profiles of S. torminalis.

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Section: Resultsmentioning

confidence: 99%

Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications

Ak,

Tüfekci,

Mustafa

et al. 2024

Chemistry & Biodiversity

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“…These extracts represented the most intriguing samples because they were able to decrease cell proliferation through molecular mechanisms that did not include apoptosis, for example cell cycle arrest or differentiation, as suggested by other authors. [66][67][68][69] Among them, some samples (i.e. Lecinaro V6, Capolongo V36, Maturano Bianco V5, Pampanaro V14) represented autochthonous varieties, genetically certified by our research team, 27 that were recently reevaluated and also introduced in the Vitis National List.…”

Section: Food and Function Papermentioning

confidence: 99%

Metabolic and biological profile of autochthonous Vitis vinifera L. ecotypes

et al. 2015

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Vitis vinifera L. is a plant species rich in phenolic compounds that are usually associated with the health benefits of wine and grape consumption in the diet. Anthocyanins, catechins, flavonol, phenolic acids and stilbenes are key molecular constituents of the Vitis berries, affecting the quality of grape products. The purpose of this work was to identify the metabolic profiles of 37 genetically certified V. vinifera Latial accessions. In particular, qualitative and quantitative analyses of specific secondary metabolites and total phenolic and tannin contents were performed by LC-MS and spectrophotometric analysis. In addition, since plant molecules are well-known for their free radical scavenging properties, the antioxidant effects of the sample extracts were evaluated through two different antiradical assays: DPPH and FRAP tests. Finally, a preliminary screening of the antiproliferative activity of each specimen on HCT-116 human colorectal cancer cells was conducted. All the results showed a great variety and amount of phenolic compounds in all accessions; moreover, we observed a significant correlation in the extracts between the metabolite concentration and bioactivity. Besides, some samples presented extraordinary biological effects, such as reduction of tumor cell growth not associated with cytotoxicity, supporting their use as possible future adjuvants for cancer therapy. In conclusion, the present research increased the scientific knowledge about Italian autochthonous vine ecotypes in order to valorize them and support their reintroduction in the local economic system.

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Idiopathic connective tissue disorders

Luzar¹,

Calonje²

2012

McKee's Pathology of the Skin

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Dermatomyositis and duodenal carcinoid

Cited by 3 publications

References 6 publications

Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications

Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications

Metabolic and biological profile of autochthonous Vitis vinifera L. ecotypes

Idiopathic connective tissue disorders

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