Dermatomyositis, Carcinoma of Colon and Meningioma in the Same Patient

Abstract

Dermatomyositis and carcinoma of colon were diagnosed in a 66-year-old woman. Meticulous physical examination excluded further systemic or cutaneous involvement. The musculocutaneous disorders responded well to daily oral corticosteroid, and the malignant tumor was totally removed surgically. After a seven-year follow-up of actual dermatomyositis controlled by maintenance doses of prednisone ranging from 5 to 15 mg daily, the patient developed a meningioma. Current concepts and data regarding various aspects of the combination between dermatomyositis and tumors are discussed. To our knowledge, this is the first reported case of meningioma associated with dermatomyositis.

Further Aspects of Van Der Woude Syndrome (Congenital Lower Lip Pits)

“…There have been scattered reports of malignancies in children with juvenile dermatomyositis (8), including hepatocarcinoma (9), three cases of lymphoproliferative disorders (8,10), neuroblastoma (11), and nasopharyngeal carcinoma (9). Adenocarcinoma of the colon is associated with adult dermatomyositis (11). To our knowledge, this is the first reported case of dermatomyositis associated with familial polyposis coli.…”

“…Partial repigmentation occurred in 11 children (10). Repigmentation probably occurs from the untreated dermal nevus cells (11). Epidermal fibrosis may prevent this in successful cases.…”

“…Current literature supports the idea that adult patients with dermatomyositis and amyopathic dermatomyositis have an increased risk of harboring a malignancy, which increases with age (2). There have been scattered reports of malignancies in children with juvenile dermatomyositis (8), including hepatocarcinoma (9), three cases of lymphoproliferative disorders (8,10), neuroblastoma (11), and nasopharyngeal carcinoma (9). Adenocarcinoma of the colon is associated with adult dermatomyositis (11).…”

Amyopathic Dermatomyositis Associated With Familial Polyposis Coli

“…Current literature supports the idea that adult patients with dermatomyositis and amyopathic dermatomyositis have an increased risk of harboring a malignancy, which increases with age (2). There have been scattered reports of malignancies in children with juvenile dermatomyositis (8), including hepatocarcinoma (9), three cases of lymphoproliferative disorders (8,10), neuroblastoma (11), and nasopharyngeal carcinoma (9). Adenocarcinoma of the colon is associated with adult dermatomyositis (11).…”

“…There have been scattered reports of malignancies in children with juvenile dermatomyositis (8), including hepatocarcinoma (9), three cases of lymphoproliferative disorders (8,10), neuroblastoma (11), and nasopharyngeal carcinoma (9). Adenocarcinoma of the colon is associated with adult dermatomyositis (11). To our knowledge, this is the first reported case of dermatomyositis associated with familial polyposis coli.…”