Antibodies to dermatophytes (M. audouinii, T. mentagrophytes var. granulosum and var. interdigitale, T. rubrum, and T. tonsurans) were detected in sera of patients with tinea capitis and tinea corporis by charcoal agglutination tests, immunodiffusion analysis, and complement fixation tests. In tinea capitis, these antibodies were not confined to patients with deep-seated, inflammatory infections. The zoophilic variety of T. mentagrophytes induced antibody formation more frequently than the anthropophilic variety in patients with tinea corporis. Precipitating and complement-fixing antibodies were often found in sera of patients with chronic T. rubrum infections. The agglutinating, precipitating, and complement-fixing antibodies persist for a limited period of time only; therefore, the time in the course of the infection at which blood is taken is of utmost importance for the study of circulating antibodies.