Dermatosis papulosa nigra: a clinically and histopathologically distinct entity

Metin, Simon Arda; Lee, Brian W.; Lambert, W. Clark; Parish, Lawrence Charles

doi:10.1016/j.clindermatol.2017.06.001

Cited by 19 publications

(9 citation statements)

References 17 publications

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“…Dermatosis papulosa nigra is a clinical variant with multiple tiny lesions more common in patients with a Fitzpatrick skin type of at least 3 and in females. Some authors consider it a distinct entity; the histopathology, however, is identical to that of SK 16 . Multiple eruptive SKs known as the Leser–Trélat sign have gained importance as a paraneoplastic disorder 17, 18 .…”

Section: Histologic and Clinical Subtypes Of Seborrheic Keratosismentioning

confidence: 99%

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Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

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Section: Histologic and Clinical Subtypes Of Seborrheic Keratosismentioning

confidence: 99%

“…The histology is similar to that of SKs of the acanthotic or reticular type. The lesions frequently harbor mutations of FGFR3, as do SKs 16, 34, 35 .…”

Section: Pathogenesismentioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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“…These tumors are carcinomas, melanomas, or lymphomas [3]. Seborrheic keratoses are considered a variant of dermatosis papulosa nigra, which has less voluminous lesions and is specific to pigmented skin [4].…”

Section: Sirmentioning

confidence: 99%

Leser–Trélat syndrome and squamous cell carcinoma of the bladder

Loumingou¹,

Diabaté²,

Nyanga³

2022

Our Dermatol Online

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Sir, Paraneoplastic syndromes are contemporaneous with various malignant tumors. Leser–Trélat syndrome is a paraneoplastic syndrome associated with certain cancers, notably, breast, lung, kidney, hepato-digestive, melanoma, and lymphoma [1]. The pathogenesis of Leser–Trélat syndrome remains unknown. Exceptional observations associate Leser–Trélat with bladder carcinoma [2]. Herein, we report Leser–Trélat syndrome in a 75-year-old black patient with bladder carcinoma. The aim of this work is to report an unusual association. The patient was a 75-year-old male, a non-smoker, with no previous history, admitted to the urology department of the Brazzaville Hospital for bladder carcinoma. The tumor suspected on ultrasound was documented by anatomopathological examination. The incidental discovery of a rash of diffuse pigmented papules located preferentially on the trunk, consisting of lesions of variable size, measuring from 3 to 1 cm, with a soft or firm consistency and irregular surface (Fig. 1). These lesions were suggestive of seborrheic keratoses.

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“…While a Caucasian predominance has been assumed, SKs occur with near-equivalent incidence in Korean males (Fitzpatrick I-V) as in Caucasians and are generally known to occur in diverse skin types [26]. DPN is found more often in African American, East Asian, and South Asian populations (Fitzpatrick IV-VI) with a consistently reported predominance in women and is thought to be underrecognized [33][34][35][36]. There is a high likelihood of family history, especially in individuals with large numbers of lesions [37][38][39][40][41].…”

Section: Epidemiologymentioning

confidence: 99%

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Sun

Halpern

2021

Dermatology

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Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK. Dermoscopic criteria have also become increasingly important to the accurate detection of SK, and other noninvasive diagnostic methods, such as reflectance confocal microscopy and optical coherence tomography, are rapidly developing. Given their ability to mimic malignant tumors, SK cases are often used to train artificial intelligence-based algorithms in the computerized detection of skin disease. These technologies are becoming increasingly accurate and have the potential to significantly augment clinical practice. Current treatment options for SK cause discomfort and can lead to adverse post-treatment effects, especially in skin of color. In light of the discontinuation of ESKATA in late 2019, promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed. There is also a need for larger, head-to-head trials of emerging laser therapies to ensure that future treatment standards address diverse patient needs.

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Dermatosis papulosa nigra: a clinically and histopathologically distinct entity

Cited by 19 publications

References 17 publications

Recent advances in managing and understanding seborrheic keratosis

Recent advances in managing and understanding seborrheic keratosis

Leser–Trélat syndrome and squamous cell carcinoma of the bladder

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

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