Dermocosmetics for Dry Skin: A New Role for Botanical Extracts

Casetti, Federica; Wölfle, Ute; Gehring, W.; Schempp, C. M.

doi:10.1159/000329214

Cited by 27 publications

(20 citation statements)

References 53 publications

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“…Traditionally, some plants have been used for the treatment of AD for a long time as botanical compounds display interesting skin barrier-reinforcing properties [65,66]. …”

Section: Discussionmentioning

confidence: 99%

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition. Objectives: We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients. Methods: Children aged 2-6 years with dry skin and atopic predisposition were randomized into 2 groups: group 1 received emollients containing PIPJ and natural lipids, while group 2 received petrolatum-based emollients. Skin condition and biophysical properties of the skin barrier were assessed at inclusion and weeks 4, 12 and 16. Results: Skin condition improved significantly in all children. Comparing the groups, children treated with emollients containing PIPJ showed significantly higher stratum corneum hydration values and significantly lower transepidermal water loss values at week 16 on the forearm and forehead. A significant decrease in skin pH was noted in group 2 on the forearm and forehead; group 1 showed a stable course. Conclusion: Early intervention with emollients in children with dry skin condition and atopic predisposition may improve their skin condition during daily emollient application. PIPJ-based formulations may be helpful to maintain skin barrier integrity.

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“…Traditionally, some plants have been used for the treatment of AD for a long time as botanical compounds display interesting skin barrier-reinforcing properties [65,66]. …”

Section: Discussionmentioning

confidence: 99%

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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“…TE has undergone full safety testing as is necessary for clinical trials and is already marketed in skin care products [31] (e.g. Imlan, Birken AG, Germany) which have been tested for tolerability on normal and atopic skin with good results.…”

Section: Discussionmentioning

confidence: 99%

Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions

Metelmann

Brandner

Schumann

et al. 2014

Skin Pharmacol Physiol

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The acceleration of wound healing is a major surgical concern. A triterpene extract from birch bark (Betulae cortex) experimentally enhances keratinocyte differentiation in vitro and accelerates wound healing ex vivo. We conducted an open, blind-evaluated, controlled, prospective, randomized (1:1) phase II clinical trial in patients requiring split-thickness skin graft transplantation at two university hospitals in Germany. Donor sites on the upper legs were covered with a moist silicone-coated dressing. Oleogel-S10 ointment containing 10% birch bark extract was randomly applied to the distal or proximal half of the wound, with the other half serving as an intraindividual control, for 14 days after the skin graft surgery. The primary efficacy variable was faster reepithelialization as determined from macrophotographs by independent, blinded experts. Twenty-four patients were randomized and completed the trial. After the 14-day test period, the planned interim analysis revealed a highly significant (p 0.0001) superiority of Oleogel-S10 in the primary efficacy variable and the trial was terminated early due to ethical concerns. The treatment side was also better reepithelialized and more similar to normal skin after 3 months. In conclusion, Oleogel-S10 significantly accelerated reepithelialization at split-thickness skin graft donor sites. Treatment with Oleogel-S10 was safe and well tolerated. i 2014 S. Karger AG, Basel

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“…The aqueous extract of Simarouba amara promoted the differentiation of human skin keratinocytes and increased the production of involucrin, cholesterol and ceramides as well thus it may be used for dry skin as it also improves water retention by the stratum corneum (Bonté et al, 1996;Casetti et al, 2011). Due to these findings, a patent was registered in 1997 for cosmetic or pharmaceutical use for the skin (Bonté et al, 1997).…”

Section: Other Biological Activitiesmentioning

confidence: 99%