Dermoscopic diagnosis of scurvy

Wambier, Carlos Gustavo; Cappel, Mark A.; Werner, Betina; Rodrigues, Érika Dayane Leal; Welling, Mariana Sandri Schumacher; Netto, Mário Rodrigues Montemór; Wambier, Sarah Perillo de Farias

doi:10.1016/j.jaad.2016.07.025

Cited by 14 publications

(12 citation statements)

References 2 publications

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“…Vitamin C is instrumental in maintaining the integrity of the soft tissue through its role in collagen synthesis 39 . One relatively pathognomonic sign of scurvy is the dermoscopic finding of keratotic plugging of the hair follicle, which is a hyperkeratotic papule with spiral or corkscrew unerupted hairs lesions, along with an increase in thickness of the stratum corneum in the absence of any inflammation 40 . A superficial perivascular and perifollicular lymphohistiocytic infiltrate can also be seen but is nonspecific 41 .…”

Section: Dermatological and Soft Tissue Findingsmentioning

confidence: 99%

Revisiting the pathobiology of scurvy: a review of the literature in the context of a challenging case

et al. 2020

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Scurvy is a nutritional disorder resulting from vitamin C deficiency. Although rare in developing countries, scurvy continues to develop in settings of limited dietary intake such as post-gastrointestinal surgery and restrictive dietary habits. The disease primarily affects the skin and soft tissue. As the state of deficiency persists, hematological and immunological sequelae may develop. The classic signs of scurvy are not always present and can be altered by the presence of other comorbidities. In this article, we present a challenging case of scurvy in an older male from an urban tertiary healthcare setting. We review the atypical and uncommon clinical and pathological findings of scurvy including those seen in the skin, blood, and bone marrow. We also review contemporary research findings that provide a better understanding of the pathogenicity and clinical manifestations of vitamin C deficiency.

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Section: Dermatological and Soft Tissue Findingsmentioning

confidence: 99%

Revisiting the pathobiology of scurvy: a review of the literature in the context of a challenging case

et al. 2020

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“…Sin embargo, esta prueba no está disponible en muchos centros. Clásicamente, los signos y síntomas del escorbuto ocurren cuando los niveles de ácido ascórbico plasmático están por debajo de 0,2 mg/dl (11 µmol/l) 7,8 . El paciente tenía anemia leve, eritrosedimentación acelerada y un valor de vitamina C plasmática de 0,5 mg/dl.…”

Section: Comentariosunclassified

Escorbuto en el siglo XXI

Oxilia¹,

Alonso²,

Sel³

et al. 2020

Dermatol. Argent.

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El escorbuto es una enfermedad causada por la deficiencia de vitamina C o ácido ascórbico. Sus manifestaciones clínicas son variadas debido a que esa vitamina es un cofactor de enzimas que intervienen en numerosos procesos, como la síntesis de colágeno y la absorción de diferentes nutrientes. La expresión cutánea característica son las petequias foliculares con pelos en cuello de cisne y en tirabuzón. El compromiso mucoso se manifiesta como hipertrofia y hemorragia gingival, gingivitis y pérdida de piezas dentarias. El diagnóstico es clínico y puede confirmarse mediante la determinación de la vitamina C plasmática o leucocitaria. El tratamiento se basa en el aporte suplementario de esa vitamina. Se presenta el caso de un paciente de 32 años con escorbuto debido a una dieta casi exclusivamente a base de harinas y carente de frutas y verduras.

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“…Dermatoscopic findings include follicular hyperkeratosis, coiled hair and a perifollicular pale-orange halo (4)(5)(6)(7)(8).…”

Section: Diagnosis: Scurvymentioning

confidence: 99%