Dermoscopy of drug‐induced aquagenic wrinkling phenomenon

Gualdi, Giulio; Pavoni, Laura; Monari, Paola; Pg, Calzavara-Pinton; Manganoni, Maria Ausilia

doi:10.1111/jdv.13130

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…A few reports described the dermoscopy or reflectance confocal microscopy features of aquagenic syringeal acrokeratoderma. [1][2][3] In our study, high-magnification dermoscopy at incident light provided the visualization of a peculiar gruyere-like pattern that correlates with reflectance confocal microscopy features of hypertrophic stratum corneum and abnormally dilated eccrine ducts (acrosyringium). In conclusion, both techniques correlate and may support the clinical diagnosis of aquagenic syringeal acrokeratoderma, helping in the early identification of pauci-symptomatic or heterozygous cystic fibrosis.…”

Section: Key Messagementioning

confidence: 80%

Palmar wrinkling: Identification of a peculiar pattern at incident light dermoscopy with confocal microscopy correlation

Lacarrubba

Verzì

Leonardi

et al. 2016

Journal of the American Academy of Dermatology

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Section: Key Messagementioning

confidence: 80%

Palmar wrinkling: Identification of a peculiar pattern at incident light dermoscopy with confocal microscopy correlation

Lacarrubba

Verzì

Leonardi

et al. 2016

Journal of the American Academy of Dermatology

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“…Patients are asked to do the water immersion test; to immerse their hands in water at 15 °C for 5 minutes, replicating the symptoms . On dermoscopy, hypertrophy of the stratum corneum and dilation of eccrine ostia is seen after brief contact with water . In histopathology, the biopsy should be taken after water immersion.…”

Section: Section Imentioning

confidence: 99%

“…19 On dermoscopy, hypertrophy of the stratum corneum and dilation of eccrine ostia is seen after brief contact with water. 23,24 In histopathology, the biopsy should be taken after water immersion. It usually shows orthokeratosis with mild acanthosis, dilation of eccrine acrosyringia, and a vacuolated appearance of the secretory eccrine coils.…”

Section: Aquagenic Wrinkling Of the Palms (Awp)mentioning

confidence: 99%

Water‐related dermatoses

Hamie

Abou-Rahal

2018

Int J Dermatology

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Water‐related dermatoses are a spectrum of diseases that are associated with water exposure. They result either from the direct influence of water or after injury from water inhabitants. In this review, clinical entities that manifest after water exposure (aquagenic pruritus, aquagenic urticaria, and aquagenic wrinkling of the palms) will be discussed with particular focus on the reported pathogenesis. Aquatic organisms and activities can be linked to cutaneous injuries that require identification and distinct management. Marine and freshwater dermatoses were summarized to provide physicians with easy access to the causative organism, method of injury, and appropriate management.

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“…Editor We read the letter 'Dermoscopy of drug-induced aquagenic wrinkling phenomenon' with quite interest in your journal. Gualdi et al 1 have reported an aquagenic syringeal acrokeratoderma (ASA) case induced by probably indomethacin that withdrawal of the drug resulted in improvement.…”

Section: Role Of Cyclooxygenase Inhibitors In Aquagenic Syringeal Acrmentioning

confidence: 99%

“…These ASA reports with the drug use have been associated with increased sodium retention in the epidermal keratinocytes, and therefore increased capacity of water uptake in the stratum corneum similar to renal side-effects of COX inhibitors. 1,7,8 Moreover, it was noted that the patients with ASA were underdiagnosed or unreported, and ASA is not as rare as…”

Section: Role Of Cyclooxygenase Inhibitors In Aquagenic Syringeal Acrmentioning

confidence: 99%