Dermoscopy of Pigmented Lesions of the Mucosa and the Mucocutaneous Junction

Blum, Andreas; Simionescu, Olga; Argenziano, Giuseppe; Braun, Ralph P.; Cabo, Horacio; Eichhorn, Astrid; Kirchesch, Herbert M.; Malvehy, Josep; Marghoob, Ashfaq A.; Puig, Susana; Özdemir, Fezal; Stolz, Wilhelm; Tromme, Isabelle; Weigert, Ulrike; Wolf, Ingrid; Zalaudek, Iris; Kittler, Harald

doi:10.1001/archdermatol.2011.155

Cited by 112 publications

(45 citation statements)

References 16 publications

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“…More advanced melanoma can present with multiple patterns and colors, particularly white, blue, and/or gray (Figure 2C). 23,24 The dermoscopic appearance of acral lentiginous melanoma (ALM) is shaped by the unique furrow and ridge pattern of acral volar skin surfaces. Melanocytic features specific to ALM are the parallel ridge pattern and irregular diffuse pigmentation (Figure 2D).…”

Section: Dermoscopic Features In Melanomamentioning

confidence: 99%

Enhancing Skin Cancer Diagnosis with Dermoscopy

Wolner

Yélamos

Liopyris

et al. 2017

Dermatologic Clinics

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Synopsis Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared to naked eye examination. Three meta-analyses have all identified that dermoscopy improved diagnostic accuracy for melanoma when compared to naked eye exam. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Dermoscopy triage algorithms have been developed to help novices decide when a biopsy or a referral is most appropriate. In this chapter we illustrate the dermoscopic features that assist in identifying melanoma and keratinocyte carcinomas.

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Section: Dermoscopic Features In Melanomamentioning

confidence: 99%

Enhancing Skin Cancer Diagnosis with Dermoscopy

Wolner

Yélamos

Liopyris

et al. 2017

Dermatologic Clinics

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“…Blum et al evaluated 11 cases of VM, 10 of which were invasive, and found that the presence of blue, gray, or white colors with or without structureless areas had 100% sensitivity for melanoma [11]. de Giorgio et al described a case of superficial spreading melanoma of the vulva with a Breslow depth of 0.5 mm that presented with a blue-gray area and whitish veil [12].…”

Section: Resultsmentioning

confidence: 99%

Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?

Rogers

Pulitzer

Marino

et al. 2016

Dermatol Pract Concept

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BackgroundThere are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone.CaseAn Asian female in her fifties was referred for evaluation of an asymptomatic, irregularly pigmented patch of the clitoral hood and labia minora of unknown duration. Her past medical history was notable for Stage IV non-small cell lung cancer. She denied a personal or family history of skin cancer. Dermoscopic evaluation of the vulvar lesion revealed heterogeneous brown and black pigmentation mostly composed of thick lines. There were no other colors or structures present. As the differential diagnosis included vulvar melanosis and mucosal melanoma, the patient was recommended to undergo biopsy, which was delayed due to complications from her underlying lung cancer. Repeat dermoscopic imaging performed three months later revealed significant changes concerning for melanoma, including increase in size, asymmetric darkening, and the appearance of structureless areas and central blue and pink colors. Histopathological examination of a biopsy and subsequent resection confirmed the diagnosis of melanoma in situ.ConclusionPreviously described dermoscopic features for mucosal melanoma may not have high sensitivity for early melanomas. Additional studies are needed to define the dermoscopic characteristics of mucosal melanomas that aid in early detection. Health care providers should have a low threshold for biopsy of mucosal lesions that show any clinical or dermoscopic features of melanoma, especially in older women.

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“…A multicenter study that examined the dermoscopic appearance of mucosal lesions revealed that the combination of structureless zones with blue, gray or white color(s) is useful for the diagnosis of malignant lesions [1]. The highest diagnostic sensitivity was achieved when considering only the presence of blue, gray, or white color [1–3]. Furthermore, polymorphous vessels is also a hint for malignancy, particularly melanoma [4,5].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, polymorphous vessels is also a hint for malignancy, particularly melanoma [4,5]. Additional clues to the diagnosis of our case included the age of the patient and the presentation of a new lesion [1]. …”

Section: Resultsmentioning

confidence: 99%

Dermoscopic appearance of an amelanotic mucosal melanoma

Blum

Beck-Zoul

Held

et al. 2016

Dermatol Pract Concept

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BackgroundHypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors.CaseA female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years. After no response to two weeks of local treatment for suspected herpes simplex infection, her gynecologist performed a skin biopsy. Based on the histopathological diagnosis of an amelanotic melanoma (Breslow thickness of 1.3 mm) the patient was referred to dermatology for further assessment. Polarized dermoscopy revealed a distinct asymmetric, sharply demarcated homogenous white papule (4 × 5 mm) as well as polymorphous vessels.ConclusionDermoscopy may aid in the diagnosis of amelanotic mucosal melanomas. Our case revealed a structureless white area and polymorphous vessels. Additional clues to the diagnosis were the advanced age of the patient and the clinical presentation of a new lesion.

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Dermoscopy of Pigmented Lesions of the Mucosa and the Mucocutaneous Junction

Cited by 112 publications

References 16 publications

Enhancing Skin Cancer Diagnosis with Dermoscopy

Enhancing Skin Cancer Diagnosis with Dermoscopy

Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?

Dermoscopic appearance of an amelanotic mucosal melanoma

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