Desalination for sustaining agricultural production is conceived as an alternative water source in some Mediterranean countries faced with climatological and hydrological constraints. Although high costs are often cited as limiting factors, how farmers discern desalinated water has not been discussed in-depth in the literature. This paper aims to deepen how desalination is perceived by irrigators, what driving factors are affecting irrigation communities’ decision-making processes, and what learnings can be drawn from their experiences regarding desalination acceptance or rejection. Eleven irrigation communities have been selected from Alicante and Murcia regions (South-East Spain), which account for more than 60,000 irrigators and 120,000 ha. Questionnaires were conducted between March and December 2019. Results highlighted the main advantages (water availability and supply security) and disadvantages (high price affecting profitable crop options, high-energy consumption, water quality standards, the production capacity of desalination plants, no seasonal variation in water production, and shortages due to technical problems) of using desalinated water. Additionally, through the analysis of regional and national press news, it can be concluded that socio-political aspects, such as corruption, cost overruns, and political disputes are also considered.