ÔØ Å ÒÙ× Ö ÔØThis is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Keywords Thermometry · Fever · Temperature monitoring · Infectious diseases · Entropy · ApEn
A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT
A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPTAbstract Body temperature monitoring provides healthcarers with key clinical information about the physiological status of patients. Temperature readings are taken periodically to detect febrile episodes and consequently implement the appropriate medical countermeasures. However, fever is often difficult to assess at early stages, or remains undetected until the next reading, probably a few hours later. The objective of this paper is to develop a statistical model to forecast fever before a temperature threshold is exceeded to improve the therapeutic approach to the subjects involved. To this end, temperature series of nine patients admitted to a general Internal Medicine ward were obtained with a continuous monitoring holter device, collecting measurements of peripheral and core temperature once per minute. These series were used to develop different statistical models that could quantify the probability of having a fever spike in the following 60 minutes. A validation series was collected to assess the accuracy of the models. Finally, the results were compared with the analysis of some series by experienced clinicians. Two different models were developed: a logistic regression model and a linear discrimination analysis model. Both of them exhibited a fever peak forecasting accuracy above 84%. When compared with experts assessment, both models identified 35 out of 36 fever spikes (97.2%). The models proposed are highly accurate in forecasting the appearance of fever spikes within a short period of time in patients with suspected or confirmed febrile related illnesses.