Descriptive epidemiology of haemophilia in Maharashtra, India

Abstract

Secondary data on haemophilia cases in the state of Maharashtra, India were compiled and analysed. A total of 2192 haemophiliacs could be accounted from case papers and pedigrees, representing approximately 60% of the estimated number of cases in the state. Ratio of haemophilia A to haemophilia B was 4.2:1. Severe haemophiliacs constituted the majority of haemophilia A and B cases. About 70% of patients did not report any family history. Age distribution of cases suggested that the longevity of severe haemophiliacs was less than 30 years. Geographical distribution revealed clustering of cases around three established haemophilia clinics, with large parts of the state showing no cases. Although the cumulative number of cases showed an ascending trend, there was a 90% decrease in the number of cases registered between 1989 and 2000, suggesting that case recruitment from areas around the facilities had been achieved. Most cases showed delayed diagnosis, as the majority of severe haemophiliacs was being diagnosed at around 11-15 years of age. However, increasing awareness about haemophilia was reflected in a four-fold increase in referrals of severe cases over a 10-year period and increased registration of cases under 5 years of age. This study highlights that haemophilia services in India are still in their infancy, and increased awareness among healthcare providers as well as expansion of treatment facilities are still the primary areas for improvement of treatment.

Descriptive Epidemiology and Complications of Haemophilia in Assiut, Egypt

“…These results were in concordant with the results of multiple previous studies [4], [7]- [9] where the majority of hemophilic cases in their studies were hemophilia A. Also, in the present study, the majority of diagnosed hemophilia cases 51 (68%) their ages were less than 25 years old and only 24 (32%) were more than 25 years old, these results were in agreement with the results of Stonebraker et al [3] and with KAR et al [8] , where the majority of diagnosed hemophilia cases were younger than 25 years old. Gender distribution revealed that 71(94.7%) were males and 4(5.3%) were females.…”

“…These findings were in agreement with Alzubaidy [10] as 65% of all hemophilic patients were in rural areas and 35% were in urban areas, in comparison with KAR et al [8] (58%) of hemophilic patients residing in urban and peri-urban areas,(10%) in large towns, while (25%) were in rural areas, the reason for that difference hemophilic patients were clustered around the hemophilia centers or clinics that usually present in urban regions.…”

Descriptive Epidemiology of Hemophilia and Other Coagulation Disorders in Mansoura , Egypt

“…The purpose of this study was to generate base line epidemiological information on the status of hemophilia in MUCH. In the last 6 years increase in number of detecting of sever hemophilia in infancy indicating increased awareness among practitioners about hemophilia5…”

An unusual case of pleural-based tumor with life-threatening post-operative complication

“…Worldwide, the incidence of hemophilia A and B is about 15–20 per 100,000 males. [2] Hemophilia A is almost five-times more common,[3] with the reported incidence of hemophilia B or Christmas disease being around 1 in 60,000. [4]…”