Descriptive epidemiology of lung cancer and current status of tobacco control measures in Central and South America

Piñeros, Marion; Sierra, Mónica S.; Forman, David

doi:10.1016/j.canep.2016.03.002

Cited by 25 publications

(29 citation statements)

References 27 publications

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“…Mortality from tobacco‐related cancers, such as lung, bladder, oral cavity, and esophageal cancer, is unsurprisingly higher among Mexican Americans, given their higher smoking prevalence . In women, lung cancer mortality is substantially higher in both Mexican Immigrants and Mexican Americans, which corresponds to historical smoking patterns and a very low smoking prevalence in Mexico among women …”

Section: Discussionmentioning

confidence: 99%

“…26 In women, lung cancer mortality is substantially higher in both Mexican Immigrants and Mexican Americans, which corresponds to historical smoking patterns and a very low smoking prevalence in Mexico among women. 26,27 For breast cancer, Mexican American women, with higher prevalence of obesity, 18,19 and lower likelihood of the protective benefits associated with high fertility, young age at first childbirth, and breastfeeding, which are more prevalent in Mexico, have higher mortality than Mexican women in postmenopausal ages. The rates for Mexican Immigrants were not substantially different from Mexican women, suggesting that the availability of more widespread screening and improved access to quality treatment 28,29 in the US may balance out the likely increased risk associated with living in the US.…”

Section: Cancer Epidemiologymentioning

confidence: 99%

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Migration from Mexico to the United States: A high‐speed cancer transition

Pinheiro

Callahan

Stern

et al. 2017

Intl Journal of Cancer

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Differences and similarities in cancer patterns between the country of Mexico and the United States’ Mexican population, 11% of the entire US population, have not been studied. Mortality data from 2008–2012 in Mexico and California were analyzed and compared for causes of cancer death among adult and pediatric populations, using standard techniques and negative binomial regression. A total of 380,227 cancer deaths from Mexico and California were included. Mexican Americans had 49% and 13% higher mortality than their counterparts in Mexico among males and females, respectively. For Mexican Immigrants in the US, overall cancer mortality was similar to Mexico, their country of birth, but all-cancers-combined rates mask wide variation by specific cancer site. The most extreme results were recorded when comparing Mexican Americans to Mexicans in Mexico: with mortality rate ratios ranging from 2.72 (95%CI: 2.44–3.03) for colorectal cancer in males to 0.28 (95%CI: 0.24–0.33) for cervical cancer in females. These findings further reinforce the preeminent role that the environment, in its multiple aspects, has on cancer. Overall, mortality from obesity and tobacco-related cancers was higher among Mexican origin populations in the US compared to Mexico, suggesting a higher risk for these cancers, while mortality from prostate, stomach, and especially cervical and pediatric cancers was markedly higher in Mexico. Among children, brain cancer and neuroblastoma patterns suggest an environmental role in the etiology of these malignancies as well. Partnered research between the US and Mexico for cancer studies is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Cancer Epidemiologymentioning

confidence: 99%

Migration from Mexico to the United States: A high‐speed cancer transition

Pinheiro

Callahan

Stern

et al. 2017

Intl Journal of Cancer

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“…Among males, lung cancer mortality patterns with the highest rates were Uruguay (44.5), Argentina (30.8) and Chile [39]. In females, countries with the highest lung cancer mortality rates were Venezuela (9.3), Argentina (7.8), Colombia (7.7) and Brazil (7.6) [74]. During the last five years, stomach cancer was one of the five most frequently diagnosed cancers in Argentina, Brazil, Bolivia, Chile, Colombia, Costa Rica, Ecuador, El Salvador, French Guyana and Peru, and one of the five leading causes of cancer death in most Latin American countries (except for females in Argentina, Cuba, and Suriname).…”

Section: Germline Cancer Predisposition In Latin Americamentioning

confidence: 99%

State of Art of Cancer Pharmacogenomics in Latin American Populations

López‐Cortés

Guerrero

Redal

et al. 2017

IJMS

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Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.

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“…Lung cancer is one of the most frequently diagnosed cancers in the world [16]. The relationship between OSAS and lung cancer has been gained attention in a cohort study, but the authors were unable to find an association between OSAS and lung cancer incidence [15].…”

Section: Introductionmentioning

confidence: 99%

Target of obstructive sleep apnea syndrome merge lung cancer: based on big data platform

Lü

Xue

et al. 2017

Oncotarget

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Based on our hospital database, the incidence of lung cancer diagnoses was similar in obstructive sleep apnea Syndrome (OSAS) and hospital general population; among individual with a diagnosis of lung cancer, the presence of OSAS was associated with an increased risk for mortality. In the gene expression and network-level information, we revealed significant alterations of molecules related to HIF1 and metabolic pathways in the hypoxic-conditioned lung cancer cells. We also observed that GBE1 and HK2 are downstream of HIF1 pathway important in hypoxia-conditioned lung cancer cell. Furthermore, we used publicly available datasets to validate that the late-stage lung adenocarcinoma patients showed higher expression HK2 and GBE1 than early-stage ones. In terms of prognostic features, a survival analysis revealed that the high GBE1 and HK2 expression group exhibited poorer survival in lung adenocarcinoma patients. By analyzing and integrating multiple datasets, we identify molecular convergence between hypoxia and lung cancer that reflects their clinical profiles and reveals molecular pathways involved in hypoxic-induced lung cancer progression. In conclusion, we show that OSAS severity appears to increase the risk of lung cancer mortality.

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Descriptive epidemiology of lung cancer and current status of tobacco control measures in Central and South America

Abstract: The high burden of lung cancer in the region highlights the need to improve long term information and strengthen current tobacco control policies including aggressive taxing measures and supporting smoking cessation in order to achieve the targeted reductions in smoking prevalence.

Cited by 25 publications

References 27 publications

Migration from Mexico to the United States: A high‐speed cancer transition

Migration from Mexico to the United States: A high‐speed cancer transition

State of Art of Cancer Pharmacogenomics in Latin American Populations

Target of obstructive sleep apnea syndrome merge lung cancer: based on big data platform

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