Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases

Wang, Hongyu; Liu, Jinbo; Wang, Qi; Zhao, Hongwei; H, Shi; Yu, Xiaohui; Fu, Xiaobao

doi:10.1136/bmjopen-2012-002483

Cited by 20 publications

(12 citation statements)

References 26 publications

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“…Another inflammatory mediator, homocysteine, contains a sulfur-containing amino acid, which is considered a cardiovascular risk biomarker 19 and has been related to the risk of developing myocardial infarction, hypertension, and atherosclerosis. 20 Levels of homocysteine are mediated by endothelial injury, altered coagulation, and platelet activation.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Inflammatory Markers and Quality of Life in Subjects With Acute Coronary Syndrome

Yuan

Wang

et al. 2016

Respir Care

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BACKGROUND: The objective of this work was to examine the relationship between obstructive sleep apnea (OSA) and inflammatory markers and quality of life in patients with acute coronary syndrome, especially undergoing percutaneous coronary intervention. METHODS: One hundred eighteen subjects were admitted with acute coronary syndrome over 1 y who had symptoms of OSA and positive polysomnography on admission. Of these subjects, 53 underwent primary percutaneous coronary intervention during their admission, and 65 had medical management. We then compared inflammatory markers by OSA status. We also assessed cardiac symptoms using the Seattle Angina Questionnaire and sleep symptoms using the Epworth Sleepiness Scale. RESULTS: Subjects in the percutaneous coronary intervention group had a higher oxygen desaturation index (ODI) (P ‫؍‬ .02) and apnea-hypopnea index (AHI) (P ‫؍‬ .048) compared with those in the medical management group. In percutaneous coronary intervention subjects, the moderate-severe OSA group (AHI > 15/h) had a higher hematocrit (P ‫؍‬ .047), homocysteine (P ‫؍‬ .01), and highsensitivity C-reactive protein (P ‫؍‬ .045) compared with those with no or mild OSA (AHI < 15/h). There was a significant correlation between high-sensitivity C-reactive protein and both AHI (r ‫؍‬ 0.46, P ‫؍‬ .001) and ODI (r ‫؍‬ 0.47, P < .001). Those with moderate-severe OSA had higher Epworth Sleepiness Scale (P ‫؍‬ .002), greater physical limitation (P ‫؍‬ .01), and lower treatment satisfaction and disease perception (P ‫؍‬ .007), as judged by subscales of the Seattle Angina Questionnaire, compared with those with no or mild OSA. Finally, subjects undergoing percutaneous coronary intervention with lower AHI (r ‫؍‬ 0.48, P < .001) and ODI (r ‫؍‬ 0.49, P < .001) reported higher treatment satisfaction. CONCLUSIONS: Subjects with acute coronary syndrome undergoing percutaneous coronary intervention who had moderate-severe OSA showed higher levels of inflammatory mediators and lower treatment satisfaction and disease perception. These factors may increase the risk of adverse sequelae by increasing the systemic inflammatory response.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Inflammatory Markers and Quality of Life in Subjects With Acute Coronary Syndrome

Yuan

Wang

et al. 2016

Respir Care

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“…16 Other studies also indicated CAVI were independently related to Cr and homocysteine. 9,17,18 Study on another minority in China namely Miao minority showed that age, SBP, uric acid, BMI were independent influencing factors of CAVI. 19 Therefore, the above studies informed us that the influencing factors of CAVI were different in different populations.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 Recent years, many studies about CAVI found that it was closely related to vascular injuries in patients with hypertension, diabetes mellitus and dyslipidemia, and was regard as a useful tool for screening of vascular health in patients with metabolic syndrome. 3,[5][6][7][8][9][10][11] Furthermore, the new vascular health classification also included CAVI as an evaluation index of vascular health. 12 However, few study assessed CAVI in a minority population of China.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cardio-Ankle Vascular Index and Influencing Factors in Natural Population of She minority in China

Liu¹,

Hong²,

Wu³

et al. 2017

Intern Med Open J

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Objective: The present study was designed to investigate the influencing factor of cardio-ankle vascular index (CAVI) in natural population of She minority in China. Methods: Five hundred and twenty-four subjects were enrolled into our study (male 227 and female 297). Main analyzing indexes included vascular related markers namely of CAVI and carotid artery intima-media thickness (CIMT) and blood markers. Results: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were high in the entire population (150.08±23.32 mmHg, 91.15±12.42 mmHg). CAVI, left CIMT and right CIMT were normal. Univariate analysis showed CAVI was positively correlated with age, waist hip ratio (WHR), SBP, DBP, pulse pressure (PP), blood urea nitrogen (BUN), serum creatinine (Cr), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high sensitive C reactive protein (hs-CRP), left CIMT and right CIMT (r=0.570, 0.240, 0.512, 0.372, 0.459, 0.231, 0.095, 0.182, 0.158, 0.164, 0.167, 0.169, 0.395, 0.407, all p<0.05). Multivariate linear regression analysis (selected factors including age, heart rate (HR), body mass index (BMI), WHR, SBP, DBP, PP, blood uric acid (UA), BUN, Cr, FPG, TC, TG, high density lipoprotein cholesterol (HDL-C), LDL-C, hs-CRP, left CIMT and right CIMT) showed that age, SBP, FPG, hs-CRP, TG and Cr were the independent related factors of CAVI (adjusted R 2 =0.399). Conclusion: Age, systolic blood pressure, fasting plasma glucose, high sensitive C-reactive protein, triglyceride and creatinine levels were independent factors of CAVI in natural populations of She minority in China.

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“…It has been stated that hyperhomocysteinemia increases cardiovascular diseases, and that folate supplementation decreases homocysteine level and drops this risk (16). It is also stated that chronic hyperhomocysteinemia leads to coronary artery diseases, atherosclerosis and hypertension at some extent, and hyperhomocysteinemia has been detected in more than the half of the group people in a study made with hypertensive patient group (21). It was stated that every 5 μmol/L increase in the homocysteine concentration associated with increased atherosclerosis risk in 60-80% rate (22).…”

Section: Discussionmentioning

confidence: 99%

Homocysteine levels in patients with masked hypertension

Yücel

Bekçi²,

Taner³

et al. 2014

Anadolu Kardiyol Derg

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Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with MHT. Patients with high blood pressure showed higher homocysteine levels when compared to MHT (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with MHT, homocysteine levels may not have any significant effect upon high blood pressure levels. (Anadolu Kardiyol Derg 2014; 14: 357-62)

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Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases

Cited by 20 publications

References 26 publications

The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Inflammatory Markers and Quality of Life in Subjects With Acute Coronary Syndrome

The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrome and Inflammatory Markers and Quality of Life in Subjects With Acute Coronary Syndrome

Evaluation of Cardio-Ankle Vascular Index and Influencing Factors in Natural Population of She minority in China

Homocysteine levels in patients with masked hypertension

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