Desenvolvimento de um Produto à Base de Óleo Essencial de Lippia Sidoides como Auxiliar para Prevenção e Tratamento da Estomatite Protética

Melo, C B F; Barreto, J O; Regis, Rômulo Rocha; Silva, F J A; Silva‐Lovato, Cláudia Helena; Oliveira, Vanuze Costa de; Fonseca, Said G C; Júnior, Hélio Vitoriano Nobre

doi:10.17921/2447-8938.2017v19n5p188

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“…This is an aromatic plant found naturally in Northeast Brazil and used in popular medicine as an antiseptic, scabicide, and anti-inflammatory [10,11]. The EO of L. origanoides (EOLO) has been reported for several biological activities , such as acaricidal [8,32], allelopathic [42], anesthetic [9,72], anthelmintic [20,21], antibacterial [12,17,23,24,34,[38][39][40][41]48,51,70,71,73,74], antidepressant [56], antifungal [14,22,26,28,29,31,33,50,52,62], antigingivitis [57,60], anti-inflammatory [18,45,75], antimicrobial [18,19,43,47,58], antioxidant [24,45,...…”

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confidence: 99%

Extraction, Chemical Composition and in vitro Antibacterial Activity of the Essential Oil of Lippia origanoides Kunth from Northeast Brazil

Silva

Monte

Damaceno

et al. 2022

Braz. arch. biol. technol.

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Lippia origanoides Kunth has among its synonyms Lippia sidoides Cham. and is popularly known as 'alecrim-pimenta' or 'rosemary pepper'. Essential oil of L. origanoides (EOLO) has been previously reported for several biological activities without significant acute toxicity, even at higher doses. In this study, essential oil (EO) was extracted from dried leaves, inflorescences, and branches of L. origanoides from Limoeiro do Norte, Ceará, Brazil by hydrodistillation at 3.63% (w/w) yield. Posteriorly, the presence of chemical compounds in the EOLO was identified by gas chromatography coupled to mass spectrometry (GC-MS). The analysis allowed to identify the thymol as the main metabolite (83.53%), followed by p-cymene (5.92%), caryophyllene (4.31%), γ-terpinene (3.27%), thymol methyl ether (1.18%), β-myrcene (1.00%), and α-terpinene (0.79%). The minimal inhibitory concentration (MIC) of EOLO was assessed against Gramnegative and Gram-positive bacterial pathogens such as Enterobacter aerogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, and Staphylococcus aureus. At 10 µL/mL concentration, the EOLO exhibited antibacterial activity against all the tested bacterial pathogens, and this concentration was considered as the MIC. The minimum bactericidal concentration (MBC) of EOLO was assessed at the MIC concentration, which inhibited the complete growth of all tested bacterial pathogens after 3 h. Therefore, concentrations less than 10 µL/mL were set as MBC. Thus, our findings suggest that the EOLO can be used as a promising antibacterial agent in the industries. HIGHLIGHTS• Thymol was identified as the main metabolite in the EOLO.• EOLO has antibacterial activity against Gram-negative and Gram-positive bacterial pathogens.• The antibacterial effect of EOLO may be associated with the presence of thymol.

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