Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Oliveira, Bianca Rodrigues de

doi:10.11606/d.60.2008.tde-31032009-132918

Cited by 6 publications

(12 citation statements)

References 23 publications

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“…The hydrodynamic diameter (Hd) varied from 129.3 nm to 240.3 nm, and the tests in Trypanosoma evansi showed positive results in two concentrations (0.5% and 1.0%). In the present study, we obtained a nanoemulsion with a Hd lower than those described by Oliveira et al [13,14] and with Hd intermediate to that described by Baldissera et al [15]. It is important to analyze the hydrodynamic diameter because it characterizes nanoformulations and allows assessing its stability over time and during dispersion necessary to toxicity experiments.…”

Section: Discussionsupporting

confidence: 56%

“…The method used in the present study was suitable for obtaining a nanoemulsion with good homogeneity and an excellent hydrodynamic diameter when compared to literature date [13][14][15], as well as maintaining its stability for more than four months, when stored at room temperature.…”

Section: Discussionmentioning

confidence: 92%

“…Oliveira [13] produced a nanoemulsion based on andiroba oil, aiming to combat the mosquito Aedes aegypti, using a low-energy method, with Span and Tween as the surfactant. The Hd (hydrodynamic diameter) was less than 300 nm, and the tests in humans showed positive results for insect repellent action.…”

Section: Discussionmentioning

confidence: 99%

“…In the current scientific literature, to our knowledge, there are only three studies that refer to the development of nanoformulations with andiroba oil [13][14][15]. Other plant oils with therapeutic properties have been incorporated in nanomaterials, but few have been studied for their biocompatibility and toxicity [9,14,16].…”

mentioning

confidence: 99%

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Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Milhomem-Paixão

Fascineli

Muehlmann

et al. 2017

Journal of Nanomaterials

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Andiroba oil (AO) is obtained from an Amazonian plant and is used in traditional medicine. We carried out a comparative study to test the cytotoxicity, genotoxicity, and hematotoxicity of the oil and its nanoemulsion (AN) in vitro (fibroblasts, lineage NIH/3T3) and in vivo (Swiss mice). The AN was characterized by DLS/Zeta, and its stability was investigated for 120 days. The biological activity of AN was assessed in vitro by MTT test and cell morphology analyses and in vivo by micronucleus, comet, and hematotoxicity tests. The AN presented a hydrodynamic diameter (Hd) of 142.5 ± 3.0 and PDI of 0.272 ± 0.007 and good stability at room temperature. The MTT test evidenced the cytotoxicity of AO and of AN only at their highest concentrations, but AN showed lower cytotoxicity than AO. A lower cytotoxicity of AN, when compared to AO, is in fact an interesting data suggesting that during therapeutic application there will be a lower impact in the cell viability of healthy cells. Cytotoxicity, genotoxicity, and hematotoxicity were not observed in vivo. These tests on the biological and toxicological effects of andiroba oil and nanostructured oil are still initial ones but will give a direction to future application in cosmetics and/or the development of new phytotherapics.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Milhomem-Paixão

Fascineli

Muehlmann

et al. 2017

Journal of Nanomaterials

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“…This was expected since surfactants with HLB above 7 tend to form O/W NEs, whereas surfactants with HLB below 7 tend to form water in oil (W/O) NEs . The developed NE had a pH between 4 and 5, suitable for topical application …”

Section: Resultsmentioning

confidence: 99%

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

Pacheco

Silva

Nascimento

et al. 2019

Journal of Pharmacy and Pharmacology

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Objectives Bioactive molecules derived from natural products combine the ability to absorb UV light and act as antioxidants. We developed an oil‐based sucupira (native species of the Brazilian cerrado) nanoemulsion (NE) using a high‐energy emulsification method and assessed its effectiveness in vitro. Methods An easily scalable high‐pressure homogenization method was used to prepare the formulation. NE droplets mean diameter, pH, stability, conductivity and morphology were analysed. Formulation bioactivity was assessed using HaCaT cells. Key findings The formulation presented suitable pH and size for topic administration and was stable for over 90 days upon storage at 4, 25 and 45°C. The NE showed protective effect against oxidative stress and reduced levels of UVA‐induced pro‐inflammatory cytokines IL‐6 and IL‐8. Conclusions A novel, stable and easily prepared formulation was obtained for encapsulation of sucupira oil. The protective effect of the formulation by cytokine inhibition in the early stage of the inflammatory process was shown in vitro. Combined with the antioxidant effect by inhibition of reactive oxygen species, the use of sucupira oil NE for prevention and treatment of UVA‐induced stress could contribute to decrease the effects of UV radiation on skin ageing.

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Obtenção de nanoemulsões O/A à base de óleo de semente de uva e oliva aditivadas de metoxicinamato de octila e estudo do potencial antioxidante e fotoprotetor das emulsões

Pereira¹

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Durante a nossa vida Passamos por muitos lugares Vivemos momentos que não mais voltarão E que deixaram na memória apenas as lembranças... Encontramos pessoas as quais não lembraremos E outras que jamais esqueceremos. Talvez pelo seu simples olhar, seu falar, seu sorriso... Ou talvez pelo fato de terem cruzado o nosso caminho. Outras por terem nos magoado, por nos fazerem sofrer... Mas são as pessoas especiais para nós Que nos fazem sentir aquela saudade... Saudade das conversas, das brincadeiras, dos sorrisos, Das lágrimas derramadas, do não falar... Quero que saibam que entre as pessoas especiais que fazem parte da minha vida Vocês são algumas delas." Agradecimento especial: Aos amigos e colegas de laboratório Bianca, Cínthia, Fer Frota, Giselly, Jackie, Land, Maria Fer, Mateus e Mônica vocês continuam sendo as mãos mais amigas que o destino me enviou... Quando faltou idéia vocês pensaram, quando faltou mateiral vocês trabalharam, quando faltou estímulo vocês me estenderam a mão e principalmente quando não tinha conhecimento suficiente vocês partilharam. Sem vocês a realização dessa dissertação teria sido bem mais difícil. Agradecimentos Em primeiro lugar agradeço à Deus, por me conceder a vida com muita saúde, e de realizar mais uma etapa da minha vida. E ao meu anjo da guarda, meu avô Álvaro, que com certeza esteve sempre presente nesta jornada, me cuidadando, a qual muitas vezes não foi fácil! Ao meu orientador Prof. Dr. Pedro Alves da Rocha-Filho pela oportunidade de desenvolver este trabalho. Agradeço a orientação, a confiança, o respeito e a amizade. Sou muito grata por tudo. Aos meus pais Ana Lúcia e Marcus, à minha irmã Mariana, as minhas avós Glecy e Teresinha, ao Dindo e a Dinda e as minhas primas Cláudia, Cibeli, Juliana e Maria, pela participação em mais esta conquista, pela compreensão mais um vez das horas dedicadas ao mestrado e que faltaram no nosso convívio familiar, pelas inúmeras horas ao telefone as quais amenizávamos a saudade e diminuíamos a distância, pelo apoio, incentivo e principalmente pelo amor!

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Desenvolvimento e avaliação de nanoemulsões com óleos de Carapa guianensis e Copaifera sp. e estudo da ação repelente frente a Aedes aegypti.

Cited by 6 publications

References 23 publications

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Andiroba Oil (Carapa guianensis Aublet) Nanoemulsions: Development and Assessment of Cytotoxicity, Genotoxicity, and Hematotoxicity

Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells

Obtenção de nanoemulsões O/A à base de óleo de semente de uva e oliva aditivadas de metoxicinamato de octila e estudo do potencial antioxidante e fotoprotetor das emulsões

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