Desert legume Prosopis cineraria as a novel source of antioxidant flavonoids / isoflavonoids: Biochemical characterization of edible pods for potential functional food development

Asati, Vidushi; Deepa, Perinkulam Ravi; Sharma, Pankaj

doi:10.1016/j.bbrep.2022.101210

Cited by 15 publications

(11 citation statements)

References 24 publications

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“…By a grinding process of the mesocarp part of its pods, is obtained flour that contains 62% of proteins, 25% of dietary fiber, a large amount of free polyphenols and carotenoids, and low content of total carbohydrates and fat, as well as a source of calcium, potassium, magnesium, zinc, and iron (Afifi and Al-rub, 2018). Its pods are known to be rich sources of vitamin C, calcium, and iron, and to be effective in the prevention of protein-calorie malnutrition and iron-calcium deficiency in the blood (Asati et al, 2022). It is much higher in lysine than the other cereals and it is particularly appropriate for vegetarians who often lack this amino acid.…”

Section: Discussionmentioning

confidence: 99%

“…• Pods: yellow to reddish brown with cylindrical shape and 20-cm long by 0.8-cm thick. The main extracted molecules are fructose, alkaloids such as prosophylline, amino acids, saponin, 3-benzyl-2-hydroxy-urs-12-en-28-oic acid, and maslinic acid-3-glucoside (triterpenoids); flavonoids such as vitexin, puerarin, phloridzin, and daidzein; linoleic acid; 5,5 ′ -oxybis-1,3-benzenediol and 5,3 ′ ,4 ′trihydroxyflavanone 7-glycoside (polyphenols) (Karim and Azlan, 2012;Liu et al, 2012;Garg and Mittal, 2013;Afifi and Al-rub, 2018;Asati et al, 2022;Ram et al, 2022;Zhong et al, 2022). In particular, the amino acids isolated from both leaves and pods are Asp, Glu, Ser, Gly, His, Thr, Arg, Ala, Pro, Tyr, Val, Met, Cys, Ile, Leu, Phe, and Lys (Khatri et al, 2010).…”

Section: Prosopis Cineraria Components Reclaim Beneficial Biological ...mentioning

confidence: 99%

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Eco-luxury: Making sustainable drugs and cosmetics with Prosopis cineraria natural extracts

et al. 2022

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Climate change associated with global warming is a major warning of the twenty-first century, threatening ecosystems through uncontrolled temperature rises, drought, lack of water with a strong impact on productivity, economy, and worldwide life well-being. In most cases, the poor regions of the planet suffer from a lack of exploitable resources deriving from natural reserves. For this reason, wild vegetables able to grow in deserted areas are attracting increasing attention due to their beneficial properties. Among them, Prosopis cineraria has been recently recognized in the UAE not only as a cultural heritage but also as a potential source of raw materials for agri-food and pharmaceutics still poorly valued. P. cineraria occurs in most of the world's hot arid and semi-arid regions as a native or introduced species and, due to its multiple properties, could be exploited for medical, food, and, more recently, in different growing productivity fields like a luxury, especially in countries like the UAE. The use of actives-rich natural sources offers clear advantages over synthetic compounds in terms of process and product eco-sustainability. In this manuscript, we review the main properties and potential applications of P. cineraria aiming to promote the scientific interest toward the development of innovative approaches in several productive fields, including pharma and cosmetics, exploiting the versatility of materials that can be extracted from the various parts of the plant and discuss commercialization opportunities of the plant to support biodiversity and sustainability. In conclusion, P. cineraria turns out to be a plant able to grow in hostile environments, already providing nutrients for populations of Western Asia and the Indian subcontinent and possibly translatable to poor arid regions.

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Section: Discussionmentioning

confidence: 99%

Section: Prosopis Cineraria Components Reclaim Beneficial Biological ...mentioning

confidence: 99%

Eco-luxury: Making sustainable drugs and cosmetics with Prosopis cineraria natural extracts

et al. 2022

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“… Underutilized legume species Biological activities/benefits Reported nutraceuticals (Representative compounds) Reference(s) 1. Prosopis cineraria Anticancer, antioxidant, antidiabetic, hypercholesterolemia, antimicrobial Phenolics (gallic acid), flavonoids (luteolin, prosogerin A, phloridzin), isoflavonoids (puerarin, daidzein), tannins Asati et al ( 2021 ), Jangid et al ( 2022 ), Charan et al ( 2021 ), Asati et al ( 2022 ) 2. Acacia senegal Anti-inflammatory, antibacterial, antifungal, antioxidant, prophylactic against SARS-CoV-2, analgesic, anti-pyretic, anti-asthmatic Alkaloids, glycosides, flavonoids (vicenin, rutin), tannins, steroids (stigmasterol, Beta-sitosterol) Binyane and Mfengwana ( 2022 ), Sharma and Kaur ( 2017 ), Yahaya et al ( 2020 ) 3.…”

Section: Edible Legumes Of the Indian Desert Regions As Sustainable Foodmentioning

confidence: 99%

“…The fruits of the Indian desert legumes are reported to be rich in nutrition and health-benefitting nutraceuticals like flavonoids (Rathore 2009 ). On the parameter of yield, the Indian (semi) arid underutilized legumes perform on the lower side when compared to soybean, lentils and chickpea; they are nevertheless capable of thriving in sandy soils and harsh climatic conditions, have low fertilizer and water demand, and are resistant to local pests (Asati et al 2022 ). Although part of occasional specialty cuisines (like ker-sangri and Panchkuta ), these do not find popular acceptance akin to the likes of soybean and chickpea.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Nutraceutical and flavor profiles in underutilized desert legumes of India: gene editing strategies towards sustainable food development

Joshi

Sehgal

Mandal

et al. 2023

J. Plant Biochem. Biotechnol.

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Climate change has posed a challenge for food security all over the world in the form of fluctuating crop yields and novel disease outbreaks in plants. Human society’s overdependence on a few food crops does not seem a wise precedence. There are numerous underutilized/orphan/neglected legumes growing in the Indian desert regions that can come to the rescue and act as balanced and sustainable sources of nutrients and health-benefitting nutraceuticals. However, challenges such as low plant yield, unidentified metabolic pathways and off-flavor in the food products derived from them prevent the realization of their full potential. Conventional breeding techniques are too slow to achieve the desired modifications and cater to the sharply rising demand for functional foods. The novel gene editing tools like CRISPR-Cas provide more precise tool to manipulate the target genes with or without introduction of foreign DNA and therefore, have better chances to be accepted by governments and societies. The current article reports some of the relevant ‘gene editing’ success stories with respect to nutraceutical and flavor profiles in the popular legumes. It highlights gaps and future potential, along with areas requiring caution, in underutilized edible legumes of the Indian (semi) arid regions like Prosopis cineraria , Acacia senegal and Cyamopsis tetragonoloba .

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“…It can survive the adverse stress brought on by insufficient water availability. P. cineraria is a member of the Leguminosae and is used by local people to treat various ailments and as a nutritional supplement (Asati et al, 2022; Janbaz et al, 2012; Kumar et al, 2018; Ram et al, 2020). Unripe pods of P. cineraria , locally known as “Sangari,” are stored after drying and used as a food supplement.…”

Section: Introductionmentioning

confidence: 99%

HMG‐CoA reductase inhibition medicated hypocholesterolemic and antiatherosclerotic potential of phytoconstituents of an aqueous pod extract of Prosopis cineraria (L.) Druce: In silico, in vitro, and in vivo studies

Jaipal

Ram

Charan

et al. 2022

eFood

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Hydrophilic bioactive compounds are copiously exhibited in aqueous extracts owed to solubility. The study was assigned to assess the ability of phytoconstituents of aqueous pod extract of Prosopis cineraria to inhibit 3‐hydroxy‐3‐methylglutary‐coenzyme A (HMG‐CoA) reductase activity and regression in atherosclerotic plaque through in vitro, in vivo, and in silico assessments along with phytochemistry of extract. The test extract exhibited 17 leading compounds as examined by Liquid Chromatograph Triple Quadrupole Mass Spectroscope. In vitro assay of test extract showed 78.1% inhibition of HMG‐CoA inhibition (IC50 was 0.03 μg/ml). In vivo assessments, hypercholesterolemia was induced by supplementing cholesterol powder and a high‐fat diet. The treatment of test extract caused significant (p ≤ 0.001) improvements in the lipid profile and antioxidant levels. Subsequently, the reductions in the atherosclerotic plaque and improved lumen volume were pointedly observed. In silico analyses of molecular docking revealed potent interaction capabilities of cloprostenol with the target protein of HMGR. The interactions were validated through structural simulations of the molecular dynamics such as root mean square fluctuation, the radius of gyration, and solvent accessible surface area. The druggability of potent compounds was also examined. The results revealed that phytoconstituents of the test extract could inhibit HMGR and regress atherosclerotic plaque.

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Desert legume Prosopis cineraria as a novel source of antioxidant flavonoids / isoflavonoids: Biochemical characterization of edible pods for potential functional food development

Cited by 15 publications

References 24 publications

Eco-luxury: Making sustainable drugs and cosmetics with Prosopis cineraria natural extracts

Eco-luxury: Making sustainable drugs and cosmetics with Prosopis cineraria natural extracts

Nutraceutical and flavor profiles in underutilized desert legumes of India: gene editing strategies towards sustainable food development

HMG‐CoA reductase inhibition medicated hypocholesterolemic and antiatherosclerotic potential of phytoconstituents of an aqueous pod extract of Prosopis cineraria (L.) Druce: In silico, in vitro, and in vivo studies

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