For wave piercing catamarans (WPCs), the centre bow length and tunnel clearance are important design factors for slamming, passenger comfort and deck diving. An experimental study was performed here to determine the influence of centre bow and wet-deck geometry on WPC motions and loads. The vertical accelerations, magnitudes of slamming loads and vertical bending moments acting on a 112 m WPC vessel were investigated at a reduced speed of 20 knots using five centre bow (CB) and wet-deck configurations: parent CB, high CB, low CB, long CB and short CB. A 2.5 m hydroelastic segmented catamaran model was used and over 200 model tests were conducted in regular head sea waves in wave heights equivalent to 2.7 m, 4.0 m and 5.4 m at full scale. It was found that increasing the wet-deck height resulted in higher vertical accelerations due to global motions but reduced the slamming loads at a speed of 1.53 m/s in model scale (20 knots full scale). The greatest peak vertical loads acting on the centre bow ranged between 18% and 105% of the total hull weight depending on the centre bow configuration and wave height. Correlation coefficients were obtained for regression models describing the relationship between the total vertical loads and the peak vertical bending moments. It was found that a reduction of speed from 38 knots to 20 knots can reduce the maximum slam loads by approximately 30% in regular waves. When considering both low and high speeds, the Short CB was found to be a consistent design for slamming reduction in comparison with the high CB.