Design and application of a self-pumping microfluidic staggered herringbone mixer

Channon, Robert B.; Menger, Ruth F.; Wang, Wei; Carrão, Daniel Blascke; Vallabhuneni, Sravanthi; Kota, Arun K.; Henry, Charles S.

doi:10.1007/s10404-021-02426-x

Cited by 14 publications

(6 citation statements)

References 54 publications

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“…3D printing also enables the use of non-planar architectures, which is a significant advancement in the historically planar design approach to microfluidics. For example herringbone structures have been used in straight 41 and curved channels 16 for self-pumping and to induce mixing control, yet NG-MICS represents the first 3D implementation of these structures as a way to counteract parasitic Dean flow focusing.…”

Section: Discussionmentioning

confidence: 99%

Ultrathroughput immunomagnetic cell sorting platform

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Section: Discussionmentioning

confidence: 99%

Ultrathroughput immunomagnetic cell sorting platform

et al. 2022

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“…These features create disturbances in the laminar flow, inducing chaotic advection and secondary flow within the channel [50,51]. For example, expansion-contraction cavity arrays, such as the staggered herringbone mixer (SHM), slanted groove mixer (SGM), and barrier-embedded mixer (BEM), introduce spatial perturbations and create secondary flow patterns to enhance mixing efficiency [52][53][54][55]. The use of slanted grooves in the SGM generates a short-pitched spiral flow, improving mixing efficiency [55].…”

Section: Geometry-assistedmentioning

confidence: 99%

Microfluidic Mixing: A Physics-Oriented Review

Saravanakumar,

Cicek

2023

Micromachines

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This comprehensive review paper focuses on the intricate physics of microfluidics and their application in micromixing techniques. Various methods for enhancing mixing in microchannels are explored, with a keen emphasis on the underlying fluid dynamics principles. Geometrical micromixers employ complex channel designs to induce fluid–fluid interface distortions, yielding efficient mixing while retaining manufacturing simplicity. These methods synergize effectively with external techniques, showcasing promising potential. Electrohydrodynamics harnesses electrokinetic phenomena like electroosmosis, electrophoresis, and electrothermal effects. These methods offer dynamic control over mixing parameters via applied voltage, frequency, and electrode positioning, although power consumption and heating can be drawbacks. Acoustofluidics leverages acoustic waves to drive microstreaming, offering localized yet far-reaching effects. Magnetohydrodynamics, though limited in applicability to certain fluids, showcases potential by utilizing magnetic fields to propel mixing. Selecting an approach hinges on trade-offs among complexity, efficiency, and compatibility with fluid properties. Understanding the physics of fluid behavior and rationalizing these techniques aids in tailoring the most suitable micromixing solution. In a rapidly advancing field, this paper provides a consolidated understanding of these techniques, facilitating the informed choice of approach for specific microfluidic mixing needs.

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“…Passive micromixers have two common types. One is lamination-based mixers [464] and the other types are chaotic advection-based mixers [465], 3D serpentine mixers [466], zigzag or waveform mixers [467], micromixers with patterned blocks [468], obstacles [469], staggered herringbones [470], etc. For laminationbased mixers, T-shaped and Y-shaped are the broadly investigated devices, in which their main inlet channels can be split into several sub-streams and then recombined to form the main stream [471,472].…”

Section: Enhancing Microchannel Mixing and Separationmentioning

confidence: 99%

Review and Analysis of Electro-Magnetohydrodynamic Flow and Heat Transport in Microchannels

Kundu

Saha

2022

Energies

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This paper aims to develop a review of the electrokinetic flow in microchannels. Thermal characteristics of electrokinetic phenomena in microchannels based on the Poisson–Boltzmann equation are presented rigorously by considering the Debye–Hückel approximation at a low zeta potential. Several researchers developed new mathematical models for high electrical potential with the electrical double layer (EDL). A literature survey was conducted to determine the velocity, temperature, Nusselt number, and volumetric flow rate by several analytical, numerical, and combinations along with different parameters. The momentum and energy equations govern these parameters with the influences of electric, magnetic, or both fields at various preconditions. The primary focus of this study is to summarize the literature rigorously on outcomes of electrokinetically driven flow in microchannels from the beginning to the present. The possible future scope of work highlights developing new mathematical analyses. This study also discusses the heat transport behavior of the electroosmotically driven flow in microchannels in view of no-slip, first-order slip, and second-order slip at the boundaries for the velocity distribution and no-jump, first-order thermal-slip, and second-order thermal-slip for the thermal response under maintaining a uniform wall-heat flux. Appropriate conditions are conferred elaborately to determine the velocity, temperature, and heat transport in the microchannel flow with the imposition of the pressure, electric, and magnetic forces. The effects of heat transfer on viscous dissipation, Joule heating, and thermal radiation envisage an advanced study for the fluid flow in microchannels. Finally, analytical steps highlighting different design aspects would help better understand the microchannel flow’s essential fundamentals in a single document. They enhance the knowledge of forthcoming developmental issues to promote the needed study area.

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Design and application of a self-pumping microfluidic staggered herringbone mixer

Cited by 14 publications

References 54 publications

Ultrathroughput immunomagnetic cell sorting platform

Ultrathroughput immunomagnetic cell sorting platform

Microfluidic Mixing: A Physics-Oriented Review

Review and Analysis of Electro-Magnetohydrodynamic Flow and Heat Transport in Microchannels

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