Design and Application of Conjugated Polymer Nanomaterials for Detection and Inactivation of Pathogenic Microbes

Abstract

Infectious deaths due to drug resistance of pathogens caused by the abuse of antibiotics have seriously endangered public health in the world. Therefore, it is urgent to develop diversified methods for rapid detection of pathogens and antimicrobial drugs that are not prone to develop resistance. Conjugated polymers (CPs) are macromolecular compounds composed of many luminescent units through covalent bond. They have high molar extinction coefficient and strong light absorption capacity. In addition, they have good photo stability and excellent biocompatibility. In recent years, conjugated polymer nanomaterials (CPNs) have stimulated the research enthusiasm of many researchers because of the materials' small size, high fluorescence intensity, and easy modification. This article reviews the recent research progress of conjugated polymer nanomaterials in the detection and killing of pathogenic microbes.

Cationic conjugated polymer-based FRET aptasensor for label-free and ultrasensitive ractopamine detection

“…Conjugated polymers (CPs) are a type of organic semiconductor material with large delocalized π-conjugated backbones. 14 The ideal light-harvested and light-amplified properties of conjugated backbones result in the wide use of CPs in the biological field. 15 For better application in a biological environment, cationic conjugated polymers (CCPs) are constructed through the introduction of a positive charge onto the side chain of CPs.…”

Design and structural regulation of AIE photosensitizers for imaging-guided photodynamic anti-tumor application

“…11,[18][19][20] Hence, many laboratories have invested a lot of time and energy to actively pursue new types of PSs without the above limited and improved characteristics to meet the growing demands for real-time disease monitoring and cancer cell eradication. [21][22][23][24] AIE luminogens which emit strong fluorescence in the aggregation state distinguishing from the conventional ACQ fluorophores are found to sensitize oxygen to generate ROS under light irradiation to be potential PSs in PDT. [25][26][27][28][29] With their superior performances compared to traditional light materials, AIEgens have proven to be worthy in a series of high-tech fields, such as stimuli-responsive intelligent systems, [30][31][32] efficient light-emitting diodes, [33][34][35] optical displays, 36 sensitive chemical sensors, 37,38 and precision medical instruments, 39 and play an increasingly significant role in the environment, optoelectronics, medical testing and other fields closely related to life science.…”

“…11,18–20 Hence, many laboratories have invested a lot of time and energy to actively pursue new types of PSs without the above limited and improved characteristics to meet the growing demands for real-time disease monitoring and cancer cell eradication. 21–24…”

Flexible bioelectronic device fabricated by conductive polymer–based living material

“…Water-soluble CPs (WSCPs) are composed of -conjugated backbones and charged side chains (23,24). For their excellent water solubility and biocompatibility, WSCPs have been widely used in the field of bioelectronics and biosensing (25)(26)(27)(28)(29)(30)(31). In addition, WSCPs can regulate the bioelectronic processes of microorganisms for realizing novel functions.…”