Design and assessment of novel synthetic peptides to inhibit quorum sensing-dependent biofilm formation in Pseudomonas aeruginosa

From Antibacterial to Antibiofilm Targeting: An Emerging Paradigm Shift in the Development of Quaternary Ammonium Compounds (QACs)

“…Mature biofilms can be eradicated by destroying biofilm structures and inducing their detachment through physical or chemical effects . Amino acids and antimicrobial peptides, , metal chelators, quorum sensing inhibitors, surfactants, and other antibiofilm agents , can be effectively used at different stages of biofilm formation. Among them, quaternary ammonium compounds (QACs) have attracted particular attention because of their excellent hard-surface cleaning and deodorizing properties, as well as a broad spectrum of antimicrobial activity .…”