Design and Characterization of an Inhalation System of Iron and Manganese Oxide Nanoparticles for Rodent Exposure

Présumé, M.; Attoui, Michel; Maisser, Anne; Petit, G. Le

doi:10.1080/02786826.2015.1052037

Cited by 5 publications

(2 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the dose of 5 µg weekly was considered as representative of occupational exposure of workers in the context of an unintentional process such as welding [8,9]. The dose of 50 µg weekly was subsequently calculated for a NP only-containing aerosol, within the 5mg/m 3 [22]. A schematic representation of the experimental protocol is given in Supplemental Figure S3.…”

Section: Animal Exposure To Npmentioning

confidence: 99%

Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice

et al. 2016

View full text Add to dashboard Cite

In spite of the great promises that the development of nanotechnologies can offer, concerns regarding potential adverse health effects of occupational exposure to nanoparticle (NP) is raised. We recently identified metal oxide NP in lung tissue sections of welders, located inside macrophages infiltrated in fibrous regions. This suggests a role of these NP in the lung alterations observed in welders. We therefore designed a study aimed to investigate the pulmonary effects, in mice, of repeated exposure to NP administered at occupationally relevant doses. We therefore chose four metal oxide NPs representative of those found in the welder's lungs: FeO, FeO, MnFeO and CrOOH. These NPs were administered weekly for up to 3 months at two different doses: 5 μg, chosen as occupationally relevant to welding activity, and 50 μg, chosen as occupationally relevant to the context of an NP-manufacturing facility. Our results show that 3 month-repeated exposures to 5 μg NP induced limited pulmonary effects, characterized by the development of a mild peribronchiolar fibrosis observed for MnFeO and CrOOH NP only. This fibrotic event was further extended in terms of intensity and localization after the repeated administration of 50 μg NP: all but FeO NP induced the development of peribronchiolar, perivascular and alveolar fibrosis, together with an interstitial inflammation. Our data demonstrate for the first time a potential risk for respiratory health posed by repeated exposure to NP at occupationally relevant doses. Given these results, the development of occupational exposure limits (OELs) specifically dedicated to NP exposure might therefore be an important issue to address.

show abstract

Section: Animal Exposure To Npmentioning

confidence: 99%

Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Study of Andujar et al (2014) strongly suggest that welding-related UFP could be responsible, at least in part, for the pulmonary inflammation observed in welders. Présumé et al (2015Présumé et al ( , 2016, based upon metal oxide nanoparticles found in lung tissue sections of welders, investigated pulmonary effects in mice of repeated exposure to nanoparticles and demonstrated for the first time a potential risk for respiratory health posed by repeated exposure to nanoparticles at occupationally relevant doses. These results provide therefore the first evidence of a link between human exposure to nanoparticles and longterm pulmonary effects.…”

Section: Human Dose From Arc Welding and Cutting Of Stainless Steelmentioning

confidence: 99%

Estimation of emission rates and lung dose from various simulated indoor workplace related aerosol sources

Serfozo¹,

Σερφόζο²

View full text Add to dashboard Cite

Η παρούσα διδακτορική διατριβή εξετάζει τις εκπομπές αιωρούμενων σωματιδίων από διάφορες πηγές που συναντούνται στο εργασιακό περιβάλλον. Σημαντική αύξηση της αριθμητικής συγκέντρωσης και μάζας σωματιδίων οδηγεί σε αύξηση της ανθρώπινης έκθεσης και δόσης. Επομένως η προστασία του ανθρώπινου πληθυσμού από την έκθεση αιωρούμενων σωματιδίων αποτελεί σημαντικό τμήμα της παρούσας επιστημονικής εργασίας.

show abstract

Estimation of Particle Emission Rates and Calculation of Human Dose from Arc Welding and Cutting of Stainless Steel in a Simulated Confined Workspace

Serfozo

Lazaridis

2023

Aerosol Sci Eng

View full text Add to dashboard Cite

The objective of this study was to estimate the particle emission rates, human dose and retention from two arc welding processes and cutting of stainless steel. The two arc welding processes were Shielded Metal Arc Welding (SMAW) and Tungsten Inert Gas (TIG). In a simulated confined workspace of experimental chamber under controlled conditions, four different scenarios were considered, including the use of filtering face piece respirator (FFR), leaving or staying in the workspace after the emission. Deposited and retained dose in the respiratory tract was assessed for the different regions of the human respiratory tract using a dosimetry model (ExDoM2). The three investigated processes generated high particle number concentrations ranging from 2.4 to 3.6 × 106 particles/cm3 and were the highest during TIG. Among all three processes, PM10 concentrations from cutting reached the highest levels [11 and 22 (× 103) μg/m3], while SMAW had the highest contribution of fine particles [~ 4.1 (× 103) μg/m3], consisting mostly of PM1–2.5. The examination of different scenarios revealed that there is only a slight difference in respect to deposited dose while staying in the workspace for the entire investigated time period (4 h) with or without use of Filtering Facepiece Respirator (FFR). It would be more beneficial in respect to deposited dose if the exposed subject was not wearing a FFR during the emission process and would leave the polluted workspace immediately after the emission period. In the first two scenarios (staying 4 h in the polluted workspace with and without FFR), both welding processes had higher cumulative deposited (~ 23%) and retained dose (~ 20%) in thoracic region compared to cutting (~ 9% and ~ 7%). These results demonstrate that even a short emission period can cause a considerable increase in concentrations of harmful respirable particles, thus increasing the human dose. The approach applied in this study could be used for the determination of personal exposure and dose to particles of known composition particularly in confined workspaces.

show abstract

Design and Characterization of an Inhalation System of Iron and Manganese Oxide Nanoparticles for Rodent Exposure

Cited by 5 publications

References 35 publications

Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice

Exposure to metal oxide nanoparticles administered at occupationally relevant doses induces pulmonary effects in mice

Estimation of emission rates and lung dose from various simulated indoor workplace related aerosol sources

Estimation of Particle Emission Rates and Calculation of Human Dose from Arc Welding and Cutting of Stainless Steel in a Simulated Confined Workspace

Contact Info

Product

Resources

About