Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride

Gagliardi, Agnese; Cosco, Donato; Udongo, Betty P; Dini, Luciana; Viglietto, Giuseppe; Paolino, Donatella

doi:10.3390/pharmaceutics12111017

Cited by 39 publications

(28 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surfactants are classified based on their charge which include the following: (i) anionic (negative charge); (ii) cationic (positive charge); (iii) zwitterionic or amphoteric (charge depends on the pH of the medium), and; (iv) non-ionic (no charge). Generally, non-ionic surfactants are less toxic to the biological membranes than ionic ones and several derivatives have been shown to inhibit the efflux pumps and/or multi-drug-resistance-associated proteins ( Rege et al, 2002 ; Gagliardi et al, 2020c ). Examples of common non-ionic surfactants include tweens®, spans®, pluronics®, vitamin E d -α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS), and poly(vinyl alcohol).…”

Section: Methods Of Preparation For Polymeric Nanoparticles and The Rmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

et al. 2021

Self Cite

View full text Add to dashboard Cite

Advances in nanotechnology have favored the development of novel colloidal formulations able to modulate the pharmacological and biopharmaceutical properties of drugs. The peculiar physico-chemical and technological properties of nanomaterial-based therapeutics have allowed for several successful applications in the treatment of cancer. The size, shape, charge and patterning of nanoscale therapeutic molecules are parameters that need to be investigated and modulated in order to promote and optimize cell and tissue interaction. In this review, the use of polymeric nanoparticles as drug delivery systems of anticancer compounds, their physico-chemical properties and their ability to be efficiently localized in specific tumor tissues have been described. The nanoencapsulation of antitumor active compounds in polymeric systems is a promising approach to improve the efficacy of various tumor treatments.

show abstract

Section: Methods Of Preparation For Polymeric Nanoparticles and The Rmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The release profiles of IND from CUB dispersions were evaluated by means of the dialysis method using cellulose acetate dialysis tubing (Spectra/Por with molecular cutoff 12,000-14,000 by Spectrum Laboratories Inc., Eindhoven, The Netherlands) sealed at both ends with clips [7,[14][15][16][17][18]. A phosphate buffer solution pH 6.8 containing 1% SLS to maintain sink conditions constantly shaken at 100 rpm and warmed to 37 ± 0.1•C was used as the release medium.…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Cubosomes Dispersions as Enhanced Indomethacin Oral Delivery Systems: In vitro and Stability Evaluation

Alfagih

AlQuadeib

Aldosari

et al. 2021

JPRI

View full text Add to dashboard Cite

Aims: To improve the dissolution of indomethacin through developing liquid indomethacin loaded cubosomes dispersion for oral delivery. Methodology: Glyceryl monooleate based indomethacin loaded cubosomes dispersion were prepared using Taguchi design to study the effect of indomethacin to the disperse phase ratio and poloxamer 407 (PLX%) concentrations on the particle size and entrapment efficiency (%EE). Furthermore, in vitro release in phosphate buffer (pH 6.8), and morphology were investigated. Also, the stability of indomethacin loaded cubosomes dispersions was examined after 6 months storage at 25°C in the dark. Results: The prepared indomethacin cubosomes dispersions were in the nanoscale (184.53±0.7 to 261.33±0.8 nm) with reasonable %EE (49.30±2.6 to 95.55±3.4 %). Moreover, a biphasic release profile was predominant for all formulations, up to 50% of payload released after 2h followed by a second continuous sustained release phase over 24h. The kinetics of indomethacin release was best explained by Higuchi model and the mechanism of drug release from these cubosomes dispersions was by fickian diffusion mechanism. In general, the indomethacin loaded cubosomes dispersions were stable after 6 months storage at 25°C in the dark. Conclusion: Indomethacin loaded cubosomes dispersions proved to be a successful platform to encapsulate and enhance the release of indomethacin with a good stability profile over 6 months.

show abstract

“…Its bulky chemical structure, low aqueous solubility (<0.01 mg/mL) and, consequently, high lipophilicity (logP ⁓4) make its delivery a challenge [19]. Indeed, the absence of ionizable functional groups represents a serious drawback in this respect because modulation of the pH may promote the solubility of the drug in polar media, as has been true for other compounds such as doxorubicin [20][21][22] and vancomycin [23]. Regarding this, the active loading of a weak acid-modified PTX derivative, PTX-succinic acid (PTX-SA), was recently proposed [24].…”

Section: Introduction 1paclitaxel In Anti-cancer Therapymentioning

confidence: 99%

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Voci

Gagliardi

Molinaro

et al. 2021

Gels

Self Cite

View full text Add to dashboard Cite

The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol®), consistent efforts have been made to obtain suitable delivery systems able to preserve/increase PTX efficacy and to overcome the side effects correlated to the presence of some excipients. The exploitation of natural polymers as potential materials for drug delivery purposes has favored the modulation of the bioavailability and the pharmacokinetic profiles of the drug, and in this regard, several formulations have been developed that allow the controlled release of the active compound. In this mini-review, the recent advances concerning the design and applications of natural polymer-based hydrogels containing PTX-loaded biocompatible nanocarriers are discussed. The technological features of these formulations as well as the therapeutic outcome achieved following their administration will be described, demonstrating their potential role as innovative systems to be used in anti-tumor therapy.

show abstract

Design and Characterization of Glyceryl Monooleate-Nanostructures Containing Doxorubicin Hydrochloride

Cited by 39 publications

References 47 publications

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors

Cubosomes Dispersions as Enhanced Indomethacin Oral Delivery Systems: In vitro and Stability Evaluation

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels

Contact Info

Product

Resources

About