Design and characterization of prednisolone-loaded nanoparticles fabricated by electrohydrodynamic atomization technique

Huanbutta, Kampanart; Sangnim, Tanikan; Limmatvapirat, Sontaya; Nunthanid, Jurairat; Sriamornsak, Pornsak

doi:10.1016/j.cherd.2016.03.004

Cited by 19 publications

(8 citation statements)

References 30 publications

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“…2 shows the DSC thermograms of PRD, BSA, PRD-BSA:PM, SD-sd and FD-sd. PRD displayed a sharp endothermic peak at 245 °C which assigned to its melting point (Couto et al 2014, Huanbutta et al 2016, Veiga et al 1985. The same peak was also observed in the PRD-BSA physical mixture thermogram indicating the crystalline state of the drug.…”

Section: Solid Dispersions Characterisationmentioning

confidence: 52%

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The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Khoder

Abdelkader

ElShaer

et al. 2017

Pharmaceutical Development and Technology

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In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution [20:1 molar ratio (MR)]. PRD-BSA dispersed mixtures were characterized by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies. In-vitro dissolution and release studies under physiological conditions showed an immediate release of PRD from the solid dispersions, with almost 90% of the drug dissolved in the first 10 min. PRD was immediately released from BSA binding complex. This study demonstrates the potential for the use of BSA to enhance the solubility and dissolution rate, hence bioavailability, of the unionizable drugs.

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Section: Solid Dispersions Characterisationmentioning

confidence: 52%

“…While the diffraction spectrum of BSA showed a typical pattern of amorphous structure, the PRD diffractogram revealed several sharp high-intensity peaks indicating its crystalline state (Huanbutta, Sangnim, Limmatvapirat, Nunthanid andSriamornsak 2016, Li et al 2007).…”

Section: Solid Dispersions Characterisationmentioning

confidence: 99%

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Khoder

Abdelkader

ElShaer

et al. 2017

Pharmaceutical Development and Technology

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“…Infrared spectroscopy investigations pointed out the interactions between the drugs and the framework after their impregnation ( Figure S3 ). More precisely, the bands at 1700 cm − 1 , corresponding to the v(C=O) stretching of prednisolone, PP, and PS were slightly shifted once encapsulated into the nanoMOFs [ 38 , 39 ]. These results are in line with previous studies showing similar shifts in the case of acetylsalicylic acid and caffeine incorporation in MIL-100(Fe) nanoMOFs [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media

Christodoulou

Lyu

Soares

et al. 2023

IJMS

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Metal–organic frameworks (MOFs) attract growing interest in biomedical applications. Among thousands of MOF structures, the mesoporous iron(III) carboxylate MIL-100(Fe) (MIL stands for the Materials of Lavoisier Institute) is among the most studied MOF nanocarrier, owing to its high porosity, biodegradability, and lack of toxicity. Nanosized MIL-100(Fe) particles (nanoMOFs) readily coordinate with drugs leading to unprecedented payloads and controlled release. Here, we show how the functional groups of the challenging anticancer drug prednisolone influence their interactions with the nanoMOFs and their release in various media. Molecular modeling enabled predicting the strength of interactions between prednisolone-bearing or not phosphate or sulfate moieties (PP and PS, respectively) and the oxo-trimer of MIL-100(Fe) as well as understanding the pore filling of MIL-100(Fe). Noticeably, PP showed the strongest interactions (drug loading up to 30 wt %, encapsulation efficiency > 98%) and slowed down the nanoMOFs’ degradation in simulated body fluid. This drug was shown to bind to the iron Lewis acid sites and was not displaced by other ions in the suspension media. On the contrary, PS was entrapped with lower efficiencies and was easily displaced by phosphates in the release media. Noticeably, the nanoMOFs maintained their size and faceted structures after drug loading and even after degradation in blood or serum after losing almost the totality of the constitutive trimesate ligands. Scanning electron microscopy with high annular dark field (STEM-HAADF) in conjunction with X-Ray energy-dispersive spectrometry (XEDS) was a powerful tool enabling the unraveling of the main elements to gain insights on the MOF structural evolution after drug loading and/or upon degradation.

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“…Huanbutta et al described a novel approach to load therapeutic molecules into nanoparticles for colon-specific drug delivery 47. Nanoparticles containing the anti-inflammatory drug prednisolone were made by electrohydrodynamic atomization with various concentrations of Eudragit ® S100 (EDS) concentrations and prednisolone/EDS weight ratios.…”

Section: Experimental Approaches For the Design Of Nanoparticlesmentioning

confidence: 99%

<p>Top-down fabrication-based nano/microparticles for molecular imaging and drug delivery</p>

Aryal

Park

Leary

et al. 2019

IJN

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Recent breakthroughs in nanoparticle research have led to improved drug delivery and have overcome problems associated with normal drug delivery methods. Optimizing the design of nanoparticles in terms of controlled size, shape, and surface chemistry of nanoparticles can maximize the therapeutic efficacy. To maximize therapeutic effects, advanced formulation and fabrication methods have been developed. Biomedical applications of nanoparticles produced using the new fabrication techniques, including drug delivery and molecular imaging, have been widely explored. This review highlights the simple and versatile manufacturing techniques that can be used in the development of new types of nanoparticles that have strictly controlled physiochemical properties and their multifaceted advantages in drug delivery and molecular imaging.

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Design and characterization of prednisolone-loaded nanoparticles fabricated by electrohydrodynamic atomization technique

Cited by 19 publications

References 30 publications

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media

<p>Top-down fabrication-based nano/microparticles for molecular imaging and drug delivery</p>

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