Design and Compressive Behavior of Controllable Irregular Porous Scaffolds: Based on Voronoi-Tessellation and for Additive Manufacturing

Wang, Guanjun; Shen, Lida; Zhao, Jianfeng; Liang, Huixin; Xie, Dexin; Tian, Zongjun; Wang, Changjiang

doi:10.1021/acsbiomaterials.7b00916

Cited by 126 publications

(87 citation statements)

References 31 publications

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“…A probability sphere method based on Voronoi-Tessellation was used to generate the random seeds in order to construct irregular porous structures with full connectivity (Fig. 2(a)) [33] . The porous scaffolds with different porosities and irregularities could be modeled using computer aided design (CAD) software Rhinoceros with a Grasshopper plugin (version 0.9.0076) and Boolean operations.…”

Section: Design and Fabrication Of Irregular Porous Scaffoldsmentioning

confidence: 99%

“…On the basis of previous studies, we proposed a new and convenient method of modeling irregular scaffold to mimic the trabecular structure based on Voronoi-Tessellation, which separated bounding box volume into several small areas according to desired pattern (isotropic, gradient, and topological) and randomly generated seeds in the respective area, resulting in the high level of controllability in parameters successfully [33] . In this work, in order to systematically investigate the performances in BTE of the scaffolds based on the proposed method, the porous samples with varying irregularity and porosity were designed and fabricated by the SLM process with Ti-6Al-4V powders.…”

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confidence: 99%

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Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Liang

Yang

Xie

et al. 2019

Journal of Materials Science & Technology

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189

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Porous metal scaffolds play an important role in the orthopedic field, due to their wide applications in prostheses implantation. Some previous studies showed that the scaffolds with trabecular bone structure reconstructed via computed tomography had satisfactory biocompatibility. However, the reverse modeling scaffolds were inflexible for customized design. Therefore, a top-down designing biomimetic bone scaffold with favorable mechanical performances and cytocompatibility is urgently demanded for orthopedic implants. An emerging additive manufacturing technique, selective laser melting, was employed to fabricate the trabecular-like porous Ti-6Al-4V scaffolds with varying irregularities (0.05-0.5) and porosities (48.83%-74.28%) designed through a novel Voronoi-Tessellation based method. Micro-computed tomography and scanning electron microscopy were used to characterize the scaffolds' morphology. Quasi-static compression tests were performed to evaluate the scaffolds' mechanical properties. The MG63 cells culture in vitro experiments, including adhesion, proliferation, and differentiation, were conducted to study the cytocompatibility of scaffolds. Compressive tests of scaffolds revealed an apparent elastic modulus range of 1. 93-5.24 GPa and an ultimate strength ranging within 44.9-237.5 MPa, which were influenced by irregularity and porosity, and improved by heat treatment. Furthermore, the in vitro assay suggested that the original surface of the SLM-fabricated scaffolds was favorable for osteoblasts adhesion and migration because of micro scale pores and ravines. The trabecular-like porous scaffolds with full irregularity and higher porosity exhibited enhanced cells proliferation and osteoblast differentiation at earlier time, due to their preferable combination of small and large pores with various shapes. This study suggested that selective laser melting-derived Ti-6Al-4V scaffold with the trabecular-like porous structure designed through Voronoi-Tessellation method, favorable mechanical performance, and good cytocompatibility was a potential biomaterial for orthopedic implants.

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Section: Design and Fabrication Of Irregular Porous Scaffoldsmentioning

confidence: 99%

mentioning

confidence: 99%

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Liang

Yang

Xie

et al. 2019

Journal of Materials Science & Technology

Self Cite

189

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show abstract

“…Such a high level of process flexibility enable it can directly fabricate complex internal structures and customized shapes. Up to now, AM has been applied to prepare bone scaffolds from various materials, including metals [12][13][14], polymers [15][16][17] and ceramics [18][19][20], even their composites [21][22][23]. Among them, metal bone scaffolds are most promising for load-bearing bone repair [24].…”

Section: Introductionmentioning

confidence: 99%

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

Shuai

Yang

et al. 2020

Mater. Res. Express

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Iron metal possesses good biocompatibility and excellent mechanical strength, though it degrades too slowly. In this work, selective laser melting (SLM) was applied to fabricate iron-manganese (Fe-Mn) biodegradable scaffold. Results shown Fe-Mn scaffold exhibited a uniform pore structure with a porosity of 66.72±2.3%, which highly matched with as-designed model. Phase analysis revealed Fe-Mn scaffold mainly contained α-Fe, martensitic and austenitic phases. Due to the potential difference among these different phases, galvanic corrosion occurred in Fe matrix. In addition, a small amount of Mn distributed at grain boundaries also contributed to the formation of galvanic corrosion. Thus, the corrosion rate increased from 0.09±0.02 mm/year to 0.23±0.05 mm/year. The scaffold exhibited suitable mechanical properties with a yield strength of 137±8.4 MPa, an ultimate strength of 221.7±10.9 MPa. Moreover, cell assays demonstrated its good cytocompatibility. Taking these positive results into consideration, SLM processed Fe-Mn scaffold was a promising material for bone repair application.

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“…Voronoi-Tessellation to generate porous scaffolds [39] with specified and functionally graded porosity, as presented in Fig. 17.…”

Section: Wang Et Al Proposed a Top-down Design Methods Based Onmentioning

confidence: 99%

“…The mechanical properties can be controlled by changing the porosity and irregularity. Thus, the compressive properties of the designed [39] porous structures can be adjusted to the level of cortical bone.…”

Section: Wang Et Al Proposed a Top-down Design Methods Based Onmentioning

confidence: 99%

A review of the design methods of complex topology structures for 3D printing

Feng

Lin

et al. 2018

Vis. Comput. Ind. Biomed. Art

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As a matter of fact, most natural structures are complex topology structures with intricate holes or irregular surface morphology. These structures can be used as lightweight infill, porous scaffold, energy absorber or micro-reactor. With the rapid advancement of 3D printing, the complex topology structures can now be efficiently and accurately fabricated by stacking layered materials. The novel manufacturing technology and application background put forward new demands and challenges to the current design methodologies of complex topology structures. In this paper, a brief review on the development of recent complex topology structure design methods was provided; meanwhile, the limitations of existing methods and future work are also discussed in the end.

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Design and Compressive Behavior of Controllable Irregular Porous Scaffolds: Based on Voronoi-Tessellation and for Additive Manufacturing

Abstract: Changjiang (2018) Design and compressive behavior of controllable irregular porous scaffolds: based on Veronoi-tessellation and for additive manufacturing. ACS Biomaterials Science and Engineering, 4 (2). pp. 719-727.

Cited by 126 publications

References 31 publications

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Trabecular-like Ti-6Al-4V scaffolds for orthopedic: fabrication by selective laser melting and in vitro biocompatibility

Selective laser melted Fe-Mn bone scaffold: microstructure, corrosion behavior and cell response

A review of the design methods of complex topology structures for 3D printing

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