Design and Development of a Proniosomal Transdermal Drug Delivery System for Captopril

Gupta, Ankur; Prajapati, Sunil Kumar; Muthukutty, Balamurugan; Singh, Mamta; Bhatia, D.R.

doi:10.4314/tjpr.v6i2.14647

Cited by 80 publications

(68 citation statements)

References 14 publications

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“…Finally, the aqueous phase is added to the mixture and warmed on water bath. The resultant solution is cooled overnight to obtain proniosomal gel (Vora et al, 1998;Gupta et al, 2007).…”

Section: Co-acervation Phase Separation Methodsmentioning

confidence: 99%

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A review on novel vesicular drug delivery: proniosomes

et al. 2013

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Nanotechnology has brought a revolution in the field of science, which has subsequently lead to development of novel dosage forms such as niosomes, liposomes and proniosomes. Proniosomes overcome the demerits involved with niosomal and liposomal drug delivery systems. Proniosomes are liquid crystalline compact niosome hybrids which upon hydration form niosomes. They help in reducing physical stability problems involved with niosomes such as leaking, fusion, aggregation and provide convenience in dosing, distribution, transportation and storage showing improved results than conventional niosomes. This review focuses on different aspects of proniosome such as preparation, characterization, drug release, applications, merits, demerits, present scenario in market and future trends.

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“…Finally, the aqueous phase is added to the mixture and warmed on water bath. The resultant solution is cooled overnight to obtain proniosomal gel (Vora et al, 1998;Gupta et al, 2007).…”

Section: Co-acervation Phase Separation Methodsmentioning

confidence: 99%

“…The obtained pellets are washed and then resuspended to obtain a niosomal suspension free from unentrapped drug (Hu & Rhodes, 1999;BlazekWelsh & Rhodes, 2001a;Fang et al, 2001;Alsarra et al, 2005;Gupta et al, 2007;Solanki et al, 2007;Abd-Elbary et al, 2008).…”

Section: Centrifugationmentioning

confidence: 99%

A review on novel vesicular drug delivery: proniosomes

et al. 2013

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“…Surfactant:alcohol:aqueous phase ratio in the final formulation was 5:5:4 w/w/w. If the drug is incompletely dissolved in the formulation, in such case both the drug and surfactants were dissolved first in ether or chloroform, followed by vacuum evaporation of the solvent (Vora et al, 1998;Gupta et al, 2007;Yasam et al, 2013;Ramesh et al, 2013).…”

Section: Preparation Of Proniosomesmentioning

confidence: 99%

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

et al. 2014

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Nifedipine is a calcium channel blocker extensively used in the treatment of anginal and hypertension. On oral administration it undergoes extensive first pass metabolism, which outweighs its absorbance through gastrointestinal tract (GIT) and bioavailability of the drug in systemic circulation. As an alternative to oral route transdermal route of drug delivery was developed. In the present investigation, proniosomes are prepared by varying the ratio of span-40, lecithin, aqueous phase and polymer. Formulation containing span-40, lecithin, isopropyl alcohol, 0.1% glycerol (5:5:4) and HPMC (2%) showed smaller vesicle size, high entrapment efficiency. The niosomal formation after hydration and their surface morphology of optimized formulation was studied by Motic and transmission electron microscopy. FTIR and differential scanning calorimetry studies were performed to unravel and understand the solid state properties of the drug and chemical interaction with formulation excipients. The ex-vivo Franzdiffusion studies were carried out in pH 6.8 using rat skin and the results showed better permeability of niosomes with good steady state flux and enhancement ratio suggesting the potential of proniosomal carriers for improved transdermal delivery of nifedipine. Skin irritation studies for 7 days, showed that the drug when formulated as proniosomes to be non-irritant with no erythemia development compared to pure drug. From the bio-distribution studies, the vesicles prepared with hydroxy propyl methyl cellulose with span-40 was found to be ideal batch as the concentration of drug at target site was higher.

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“…They can be transformed easily into niosomes immediately upon hydration (Gupta et al, 2007). Recently, various studies proved the reliability of proniosomal gels in promoting the ocular bioavailability of different drugs.…”

Section: Introductionmentioning

confidence: 99%

Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies

2017

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Context: Vesicular drug carriers for ocular delivery have gained a real potential. Proniosomal gels as ocular drug carriers have been proven to be an effective way to improve bioavailability and patient compliance. Objective: Formulation and in vitro/ex vivo/in vivo characterization of ketoconazole (KET)-loaded proniosomal gels for the treatment of ocular keratitis. Materials and methods: The effect of formulation variables; HLB value, type and concentration of non-ionic surfactants (Tweens, Spans, Brijs and Pluronics) with or without lecithin on the entrapment efficiency (EE%), vesicle size and in vitro KET release was evaluated. An ex vivo corneal permeation study to determine the level of KET in the external eye tissue of albino rabbits and an in vivo assessment of the level of KET in the aqueous humors were performed. Results and discussion: In vivo evaluation showed an increase in bioavailability up to 20-folds from the optimum KET proniosomal gel formula in the aqueous humor compared to drug suspension (KET-SP). The selected formulae were composed of spans being hydrophobic suggesting the potential use of a more hydrophobic surfactant as Span during the formulation of formulae. Factors that stabilize the vesicle membrane and increase the entrapment efficiency of KET (namely low HLB, long alkyl chain, high phase transition temperature) slowed down the release profile. Conclusions: Proniosomal gels as drug delivery carriers were proven to be a promising approach to increase corneal contact and permeation as well as retention time in the eye resulting in a sustained action and enhanced bioavailability.

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Design and Development of a Proniosomal Transdermal Drug Delivery System for Captopril

Cited by 80 publications

References 14 publications

A review on novel vesicular drug delivery: proniosomes

A review on novel vesicular drug delivery: proniosomes

A novel vesicular transdermal delivery of nifedipine – preparation, characterization andin vitro/in-vivoevaluation

Ocular ketoconazole-loaded proniosomal gels: formulation, ex vivo corneal permeation and in vivo studies

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